CAS: 2150-46-1; Methyl 2,5-Dihydroxybenzoate

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CAS号67-56-1 甲醇 | CAS号490-79-9 2,5-二羟基苯甲酸 | CAS号89-86-1 2,4-二羟基苯甲酸 | CAS号33757-85-6 methyl 2,5-diac... | CAS号74-88-4 碘甲烷 | CAS号1083407-68-4 N-(benzyloxy)-5... | CAS号79250-47-8 5-allyloxy-2-hy... | CAS号4955-90-2 龙胆酸钠盐 | CAS号77-78-1 硫酸二甲酯 | CAS号106296-25-7 methyl 2,5-bis(... | CAS号56309-62-7 2,5-二甲氧基苯异氰酸酯 | CAS号14103-09-4 1-羟基-2,3,4,7-四甲氧基呫吨酮 | CAS号2785-98-0 2,5-二甲氧基苯甲酸 | CAS号139278-62-9 methyl 2,5-bis(... | CAS号2905-82-0 5-甲氧基水杨酸甲酯 | CAS号33757-85-6 methyl 2,5-diac... | CAS号33351-11-0 methyl 2,5-diph... | CAS号61969-53-7 2,5-二羟基-N-(2-羟乙... | CAS号2150-40-5 2,5-二甲氧基苯甲酸甲酯

2,5-二羟基苯甲酸置于硫酸体系中,用 甲醇 用作溶剂,化学反应生成2,5-二羟基苯甲酸甲酯
参考文献:Benzoxazinone And Benzothiazinone Derivatives Having Cardiovascular
标题:Benzoxazinone And Benzothiazinone Derivatives Having Cardiovascular
摘要:化合物的式子为i ##str1## 其中r代表氢,C.Sub.1-C.Sub.6烷基,C.Sub.5-C.Sub.7环烷基,亚甲二氧基或苯基,其可以被一个或两个基团独立地选择从羟基,卤素,硝基,C.Sub.1-C.Sub.6烷基或c.Sub.1-C.Sub.6烷氧基取代;R.Sub.1和r.Sub.2独立地代表氢,Coor.Sub.3,--Conr.Sub.4 R.Sub.5,##str2##--oconr.Sub.4 R.Sub.5,--ocor.Sub.3,--Nr.Sub.4 R.Sub.5,--ocoor.Sub.6,--Nr.Sub.3 Cor.Sub.7,--Nr.Sub.Conr.Sub.4 R.Sub.5,--N.Dbd.Ch--Nr.Sub.4 R.Sub.5,No.Sub.2,Cn,Oh,Sr.Sub.3,其中r.Sub.3为氢或c.Sub.1-C.Sub.6烷基,R.Sub.4和r.Sub.5独立地为氢或c.Sub.1-C.Sub.6烷基,R.Sub.6为c.Sub.1-C.Sub.6烷基,而r.Sub.7为氢,C.Sub.1-C.Sub.6烷基或c.Sub.1-C.Sub.6烷氧基,其中r.Sub.1和r.Sub.2不能同时为氢;X为氧或硫;Y表示c.Sub.2-C.Sub.6烷基链或c.Sub.5-C.Sub.7环烷基团;提供其药学上可接受的盐,并可用于制备药物组合物,用于治疗心血管疾病.

专利信息

专利号:US-9051302-B2
优先权日:2008-01-15
标 题 :Synthesis of resorcylic acid lactones useful as therapeutic agents
发明人：WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN
权利人:WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN; UNIV STRASBOURG
摘要:Disclosed are macrocyclic compounds of formulae I, I′, II, II′, III, III′, IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90.

专利号:US-2003199558-A1
优先权日:2001-12-28
标 题:Hydroxamic acid and its derivatives as inhibitors of melanocyte tyrosinase for topical skin lighteners
发明人：DOOLEY THOMAS P; CHENG LIN
权利人:INTEGRIDERM INC
摘要:Methods, compounds, and formulations are provided to reduce pigmentation in mammalian skin, comprising hydroxamic acid and its derivatives, and especially benzohydroxamic acid and its derivatives. The compounds preferably inhibit pigment synthesis in melanocytes through inhibition of melanocyte tyrosinase. The methods can be used for lightening skin, and for treating uneven skin complexions, which result from hyperpigmentation-related medical conditions such as melasma, age spots, freckles, ochronosis, and lentigo. The compounds can be used medically or cosmetically, and preferably as topical formulations.

专利号:US-10239856-B2
优先权日:2008-01-15
标题:Synthesis of resorcylic acid lactones useful as therapeutic agents

专利号:US-2004220409-A1
优先权日:2001-02-20
标题 :Flecainide synthesis
发明人：MCDANIEL WILLIAM C; RADHAKRISHNAN JAYARAMAIYER; JANICKI SLAWOMIR J
权利人:MCDANIEL WILLIAM C; RADHAKRISHNAN JAYARAMAIYER; JANICKI SLAWOMIR J
摘要:An improved, highly efficient method for the preparation of flecainide acetate (I) or other pharmaceutically acceptable salts of flecainide. The method involves a technique for preparing the staring material 1,4-bis (2,2,2-trifuoroethoxy) benzene (III) in high yields by reacting 4-fluoro-1-bromobenzene (VI) with TFE in the presence of a base and a copper-containing catalyst.

专利号:US-12036300-B2
优先权日:2021-03-31
标题:Methods and compositions for improving skin
发明人：LIAO I-CHIEN; BRIEVA PATRICIA; JUCHAUX FRANCK; BOUEZ CHARBEL; ZHENG QIAN; QIAN KUN
权利人:OREAL
摘要:A method for managing skin tone comprising reducing the synthesis of melanin by applying a skin treatment composition to skin. The skin treatment composition may include about 0.1 to about 25 wt. % of acetyl trifluoromethylphenyl valylglycine; about 0.5 to about 30 wt. % of a polyol; about 0.1 to about 30 wt. % of a silicone, fatty compound, or a mixtures thereof, wherein the skin treatment composition is an emulsion, and all weight percentages are based on the total weight of the skin treatment composition.

专利号:US-2011217335-A1
优先权日:2008-01-15
标 题 :Synthesis of resorcylic acid lactones useful as therapeutic agents