CAS: 214852-45-6; Fmoc-D-Cis-Hyp-Oh
该化合物是属于氨基酸类的化学化合物,是氢氧丙酸的衍生物,具有9氟基甲基乙基碳酸(Fmoc)保护组,在混合过程中,它通常用于浸泡合成以保护氨基酸的氨基组."D-cis"名称表明对生物活动和相互作用很重要的氢氧丙酸的具体立体化学,这种化合物通常用于合成硫化物和蛋白,特别是在生物化学和药化学的研究和开发方面,其独特的结构使得将氢氧丙酸纳入peptides,这可能影响由此产生的分子的稳定性和一致性.Fmoc-D-cis-Hy-Hy-Hy-Home在标准实验室条件下,有机溶剂中可溶解,并显示稳定性,使它成为精化物合成协议中有价值的试剂.
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139262-20-7 122996-47-8 13504-85-3物理性质
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2902600000-乙苯
2905122000-异丙醇
2905399002-1,4-丁二醇
2912110000-甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
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专利信息
专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
