CAS: 2095432-65-6; (R)-5-Fluoro-N-(4-Fluoro-3-(3-Imino-2,5-Dimethyl-1,1-Dioxido-1,2,4-Thiadiazinan-5-yl)Phenyl)Picolinamide 2,2,2-Trifluoroacetate
- 英文名称(R)-5-Fluoro-N-(4-Fluoro-3-(3-Imino-2,5-Dimethyl-1,1-Dioxido-1,2,4-Thiadiazinan-5-yl)Phenyl)Picolinamide 2,2,2-Trifluoroacetate
- 中文名称(R)-5-氟-N-(4-氟-3-(3-亚氨基-2,5-二甲基-1,1-二氧基-1,2,4-噻二嗪-5-基)苯基)吡啶酰胺2,2,2-三氟乙酸盐
- IUPAC名称(R)-5-fluoro-N-(4-fluoro-3-(3-imino-2,5-dimethyl-1,1-dioxido-1,2,4-thiadiazinan-5-yl)phenyl)picolinamide 2,2,2-trifluoroacetate
- CAS编号2095432-65-6
- MFCD编号:MFCD28963974
- 分子式:C19H18F5N5O5S分子量:523.44
- 产品CID: 1073830
- 同类组份化合物CAS2095432-65-6 (TFA)1286770-55-5 (free base)1875153-95-9 (Tosylate)1970144-54-7 (HBr)1897370-45-4 (hydrate)
- 产品分类Chemistry → Heterocyclic Building Blocks → Aromatic Heterocycles | Pyridines | Fluorinated Building Blocks | Amides
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主要参考文献
1: Thaisrivongs DA, Morris WJ, Tan L, Song ZJ, Lyons TW, Waldman JH, Naber JR, Chen W, Chen L, Zhang B, Yang J. A Next Generation Synthesis of BACE1 Inhibitor Verubecestat (MK-8931). Org Lett. 2018 Mar 16;20(6):1568-1571. doi: 10.1021/acs.orglett.8b00259. Epub 2018 Feb 26. doi: 10.1021/acs.orglett.7b03639. Epub 2018 Feb 20. doi: 10.1016/j.chroma.2018.01.042. Epub 2018 Jan 31. doi: 10.1186/s13195-018-0343-5.
5: Villarreal S, Zhao F, Hyde LA, Holder D, Forest T, Sondey M, Chen X, Sur C, Parker EM, Kennedy ME. Chronic Verubecestat Treatment Suppresses Amyloid Accumulation in Advanced Aged Tg2576-AβPPswe Mice Without Inducing Microhemorrhage. J Alzheimers Dis. 2017;59(4):1393-1413. doi: 10.3233/JAD-170056.
6: Prati F, Bottegoni G, Bolognesi ML, Cavalli A. BACE-1 Inhibitors: From Recent Single-Target Molecules to Multitarget Compounds for Alzheimer's Disease. J Med Chem. 2018 Feb 8;61(3):619-637. doi: 10.1021/acs.jmedchem.7b00393. Epub 2017 Aug 8. doi: 10.1186/s12929-017-0355-7. Review.
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