CAS: 17140-60-2; Calcium (2R,3R,4S,5R,6R)-2,3,4,5,6,7-Hexahydroxyheptanoate

专利信息

专利号:US-9982005-B2
优先权日:2013-04-04
标 题 :Macrolides and methods of their preparation and use
发明人：MYERS ANDREW G; SEIPLE IAN BASS; ZHANG ZIYANG
权利人:HARVARD COLLEGE
摘要:Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. Intermediates in the synthesis of macrolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. A general diastereoselective aldol methodology used in the synthesis of the western half is further provided.

专利号:US-11466046-B2
优先权日:2014-10-08
标题 :14-membered ketolides and methods of their preparation and use
发明人：MYERS ANDREW G; SEIPLE IAN BASS; ZHANG ZIYANG
权利人:HARVARD COLLEGE
摘要:Provided herein are methods of preparing new 14-membered ketolides via coupling of an eastern and western half moiety, followed by macrocyclization, and optional functionalization. Intermediates in the synthesis of these ketolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using these ketolides are also provided.

专利号:US-9790531-B2
优先权日:2012-08-14
标 题 :Enzymes and polymerases for the synthesis of RNA
发明人：WANG YUXUN; RAMAKRISHNAN DIVAKAR; DE FOUGEROLLES ANTONIN; WHORISKEY SUSAN
权利人:MODERNATX INC
摘要:The invention relates to compositions and methods for the design, evolution, preparation, and/or manufacture of enzymes for use with polynucleotides, primary transcripts and mmRNA molecules.

专利号:US-8596356-B2
优先权日:2010-10-28
标题 :Method of producing synthesis gas by the underground gasification of coal from a coal seam
发明人：BRANDL ANDREAS; DOHERTY DALE R
权利人:BRANDL ANDREAS; DOHERTY DALE R; BAKER HUGHES INC
摘要:Synthesis gas is more effectively produced from the underground gasification of coal from a coal seam when the casing lining is cemented with a cementitious slurry containing a cementitious material, graphite and an aluminum silicate, such as metakaolin. The cementitious slurry of the cement mix sets as a cement sheath at bottomhole static temperatures less than or equal to 65° C. The set cement may withstand extreme dry heat temperatures which are greater than or equal to 800° C.

专利号:CN-111819182-A
优先权日:2017-10-04
标 题:Synthesis of cantharidin

专利号:US-10011631-B2
优先权日:2015-12-01
标题 :Stapled helical peptides and methods of synthesis
发明人：LI XUECHEN; LEE CHI-LUNG; XU JIAOCHAO
权利人:UNIV HONG KONG
摘要:The present disclosure relates to the design and generation of stapled helical peptides that perturb protein-protein interactions (PPIs). The methods disclosed herein for preparing stapled peptides involve providing a peptide having a first amino acid that is functionalized with a salicylaldehyde ester side group and a second amino acid functionalized with a 1,2-hydroxyl amine side group; reacting the first and second amino acids to generate an N,O-benzylidene acetal moiety; and performing acidolysis of the resultant N,O-benzylidene acetal moiety to generate the stapled peptide. In many forms, the stapled helical peptides described herein are not hydrophobic.