CAS: 1481-32-9; 6-Fluoro-1-Indanone

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52085-94-6 700-84-5 161712-77-2

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对氟肉桂酸置于sodium Hydroxide,三氯化铝,氯化亚砜,Sodium Amalgam体系中,用 二硫化碳 用作溶剂,化学反应 12.0H,反应生成6-氟-1-茚酮
参考文献:Olivier,M.; Marechal,E.,Bulletin De La Societe Chimique De France,1973,P. 3092-3095
标题:Olivier,M.; Marechal,E.,Bulletin De La Societe Chimique De France,1973,P. 3092-3095

专利信息

专利号:US-6316437-B1
优先权日:1999-09-30
标题:Spirohydantoin compounds and uses thereof
发明人：HOFFMAN JACOB M
权利人:MERCK & CO INC
摘要:Spirohydantoin compounds and their pharmaceutically acceptable salts are disclosed. The synthesis of these compounds and their use as alpha 1a adrenergic receptor antagonists is also described. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds are typically selective in their ability to relax smooth muscle tissue enriched in the alpha 1a receptor subtype without at the same time inducing hypotension. One such tissue is found surrounding the urethral lining. Therefore, one utility of the instant compounds is to provide acute relief to males suffering from benign prostatic hyperplasia, by permitting less hindered urine flow. Another utility of the instant compounds is provided by combination with a human 5-alpha reductase inhibitory compound, such that both acute and chronic relief from the effects of benign prostatic hyperplasia can be achieved.

专利号:US-2023002426-A1
优先权日:2019-11-15
标题 :Chiral synthesis of a tertiary alcohol

专利号:WO-2021097139-A1
优先权日:2019-11-15
标 题 :Chiral synthesis of a tertiary alcohol