CAS: 1390637-82-7; Cyp3Cide
- 英文名称Cyp3Cide
- 中文名称(S)-1-甲基-3-(1-甲基-5-(P-对甲苯基)-1H-H-4-基)-4-(3-(哌啶-1-基)吡咯烷-1-基)-1H-吡唑并[3,4-D]嘧啶
- IUPAC名称(S)-1-methyl-3-(1-methyl-5-(p-tolyl)-1H-pyrazol-4-yl)-4-(3-(piperidin-1-yl)pyrrolidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine
- CAS编号1390637-82-7
- MFCD编号:MFCD22417344
- FDA UNII编号:ZRD2TT3Y1T
- 分子式:C26H32N8分子量:456.6
- 产品CID: 603368
- 同类组份化合物CAS1390637-82-7
- 产品分类Inhibitors/Agonists → Metabolic Enzyme → P450
物理性质
MSDS等安全信息
上下游产品
{4-chloro-6-[(3S)-3-(piperidin-1-yl)pyrrolidin-1-yl]pyrimidin-5-yl}[1-methyl-5-(4-methylphenyl)-1H-pyrazol-4-yl]methanone methylhydrazine 1-methyl-5-(p-tolyl)-1H-pyrazole-4-carbaldehyde 1-methyl-5-(4-methylphenyl)-1H-pyrazole合成工艺路线路线简述
海关参考信息
- 2902300000-甲苯
2921211000-乙二胺 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Work HM, Kandel SE, Lampe JN. Comparison of the CYP3A selective inhibitors CYP3cide, clobetasol, and azamulin for their potential to distinguish CYP3A7 activity in the presence of CYP3A4/5. Drug Metab Dispos. 2024 May
3:DMD- AR-2023-001598. doi: 10.1124/dmd.124.001598. Epub ahead of print. 48(9):778-787. doi: 10.1124/dmd.120.000017. Epub 2020 Jun 12. 46(5):493-502. doi: 10.1124/dmd.117.079855. Epub 2018 Feb 23. 45(8):957-965. doi: 10.1124/dmd.117.076307. Epub 2017 May 22.
5: Verbueken E, Alsop D, Saad MA, Pype C, Van Peer EM, Casteleyn CR, Van Ginneken CJ, Wilson J, Van Cruchten SJ. In Vitro Biotransformation of Two Human CYP3A Probe Substrates and Their Inhibition during Early Zebrafish Development. Int J Mol Sci. 2017 Jan 22;18(1):217. doi: 10.3390/ijms18010217.
合成参考文献
参考文献:10.1124/mol.119.115964
摘要:Lee TD, Lee OW, Brimacombe KR, Chen L, Guha R, Lusvarghi S, Tebase BG, Klumpp-Thomas C, Robey RW, Ambudkar SV, Shen M, Gottesman MM, Hall MD. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular Pharmacology. 2019 Nov;96(5):629–40. doi: 10.1124/mol.119.115964.
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