CAS: 1204333-58-3; 2,6-Difluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Pyridine
该化合物是丙烯的碳酸酯衍生物,其特点是2和6个位置的二氟替代物和4个位置的皮诺酸酯组.该化合物在铃木-宫浦交叉反应中是一个多功能中间体,能够合成复杂的双子体结构.用电排出氟替代成分增强了其在催化变异中的再活性,而黄甲酯组则确保了处理的稳定性和方便性.该化合物的固定结构和高纯度使其适合医药和农用化学应用,特别是在开发氟乙基循环过程中.该化合物通常作为一种晶体固体供应,其批到批量的再生性具有一致性.
- 英文名称2,6-Difluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Pyridine
- 中文名称2,6-二氟-4-(4,4,5,5-四甲基-1,3,2-二氧杂硼烷-2-基)吡啶
- IUPAC名称2,6-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
- 其它别名2,6-二氟-4-(4,4,5,5-四甲基-1,3,2-二噁硼戊环-2-基)吡啶; 2,6-Difluoropyridine-4-Boronic Acid, Pinacol Ester
- CAS编号1204333-58-3
- MFCD编号:MFCD12913987
- EINECS号:892-402-5
- 分子式:C11H14BF2NO2分子量:241.04
- 产品CID: 272714
- 产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物
相似化合物
401816-16-8 458532-86-0 1146615-89-5物理性质
MSDS等安全信息
欧盟法规
C&L通报上下游产品
2,6-difluoro pyridine bis(pinacol)diborane 4‐bromo‐2,6‐difluoropyridine合成工艺路线路线简述
📜2-(四氢-2H-吡喃-2-氧基)乙醇 以72%的收率获得2,6-二氟吡啶-4-硼酸频哪醇酯
参考文献:Biaryl Amide Compounds,Preparation Methods And Medical Applications Thereof
标题:Biaryl Amide Compounds,Preparation Methods And Medical Applications Thereof
摘要:本申请公开了一般式(i)及其类似物的raf抑制剂,包含这些化合物的制药组合物,其制备方法,以及将这些化合物用作治疗与过度raf活性有关的各种疾病(包括癌症)的治疗剂的用途.
海关参考信息
- 2905122000-异丙醇
2905143000-叔丁醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:WO-2020118597-A1
优先权日:2018-12-13
标 题 :Process for making 1- [ (3r, 4s) -4-cyanotetrahydropyran-3-yl] -3- [ (2-fluoro-6-methoxy-4-pyridyl) amino] pyrazole-4-carboxamide
发明人：CHASSAING CHRISTOPHE PIERRE ALAIN; YIN JINGJUN; CLEATOR EDWARD; SONG LICHEN; XIAO WENSONG; DAHMEN THOMAS; SALANTA DANIEL; SCHEIPERS CLAUDIA; SCHMITT HARALD
权利人:INTERVET INT BV; INTERVET INC; CHASSAING CHRISTOPHE PIERRE ALAIN; YIN JINGJUN; CLEATOR EDWARD; SONG LICHEN; XIAO WENSONG; DAHMEN THOMAS; SALANTA DANIEL; SCHEIPERS CLAUDIA; SCHMITT HARALD
摘要:New processes for the preparation of 1- [ (3R, 4S) -4-cyanotetrahydropyran-3-yl] -3- [ (2-fluoro-6-methoxy-4-pyridyl) amino] pyrazole-4-carboxamide (I) which include (i) novel more efficient synthesis for bromo and iodo pyridine intermediates, (ii) synthesis of a novel pyrazole ester intermediate which can be obtained in enantiopure form and (iii) the combination of these intermediates into compound (I).
