2.5-二甲基四氢呋喃置于aluminum Oxide,Potassium Permanganate,Copper(II) Sulfate体系中,化学反应 8.0H,以60%的收率获得2,5-己二酮 参考文献:Solvent Free Permanganate Oxidations 标题:Solvent Free Permanganate Oxidations 摘要:The Oxidations Of Organic Compounds By Permanganate Under Solvent Free Conditions Have Been Studied. Thiols And Primary Aromatic Amines Undergo Oxidative Coupling Reactions To Give Disulfides And Diazenes,Respectively,Sulfides Are Oxidized To Sulfones,Primary And Secondary Alcohols Are Converted To Aldehydes And Ketones,1,4-Diols And Cyclic Ethers Give Lactones And Arenes Are Oxidized To The Corresponding A-Ketones. The Experimental Procedure Is Simple And The Products Are Easily Isolated In Good Yields. (C) 2001 Elsevier Science Ltd. All Rights Reserved. Doi:10.1016/s0040-4039(01)01129-7
专利号:US-7314960-B1 优先权日:2006-09-28 标 题:Catalytic synthesis of oxygenate from alcohol 发明人:LIN SHENG-DIANN; HSIAO TING-CHOU 权利人:UNIV YUAN ZE 摘要:The present invention discloses a method for catalytic synthesis of oxygenate from alcohol. At first, a feeding material comprising at least one alcohol is provided. Next, a copper-containing catalyst is provided and the catalyst further comprises at least one metal element selected from the group consisting of the following: zinc, magnesium, and aluminum elements. Following that, a catalytic reaction of the feeding material over the copper-containing catalyst is carried out to synthesize at least one oxygenate.
专利号:US-8729277-B2 优先权日:2009-04-06 标 题:Processes for the synthesis of gamma nitrocarbonyl and gamma dicarbonyl compounds and their pyrrole derivatives 发明人:YANG HU; BARALT EDUARDO J 权利人:YANG HU; BARALT EDUARDO J; CHEVRON PHILLIPS CHEMICAL CO 摘要:The present invention discloses processes for producing γ-nitrocarbonyl and γ-dicarbonyl compounds, which can be precursors in the synthesis of pyrrole compounds. A process for producing pyrroles such as 2,5-dimethylpyrrole, and structurally similar pyrrole compounds, is also disclosed.
专利号:US-11498062-B2 优先权日:2016-09-30 标 题 :Phosphorus-containing solid catalysts and reactions catalyzed thereby, including synthesis of p-xylene 发明人:CHO HONG JE; FAN WEI; TSAPATSIS MICHAEL; DAUENHAUER PAUL J; REN LIMIN; LOBO RAUL 权利人:UNIV MINNESOTA; UNIV OF MASSACHUSETTS AMHERST; UNIV DELAWARE 摘要:Methods and phosphorus-containing solid catalysts for catalyzing dehydration of cyclic ethers (e.g., furans, such as 2,5-dimethylfuran) and alcohols (e.g., ethanol and isopropanol). The alcohols and cyclic ethers may be derived from biomass. One example includes a tandem Diels-Alder cycloaddition and dehydration of biomass-derived 2,5-dimethyl-furan and ethylene to renewable p-xylene. The phosphorus-containing solid catalysts are also active and selective for dehydration of alcohols to alkenes.
专利号:US-6262272-B1 优先权日:1997-11-13 标题 :Method of synthesis of pyrrole amides 发明人:RAGAN JOHN ANTHONY; MAKOWSKI TERESA WOODALL; AM ENDE DAVID JON; CLIFFORD PAMELA JANE; YOUNG GREGORY RANDALL; CONRAD ALYSON KAY; EISENBEIS SHANE ALLEN; QUALLICH GEORGE JOSEPH; ALLEN DOUGLAS JOHN MELDRUM 权利人:PFIZER 摘要:A method for preparing pyrrole-carboxyamides which selectively bind to GABAa receptors; which comprises reacting 1,3-cycloakane-diones with bromoethylacetate followed by reaction of the resulting product with an acid halide followed by reaction with an aromatic amine and finally with an amonium source at an elevated temperature.
专利号:US-7314962-B2 优先权日:2005-04-15 标题:Alkylation of aromatic compounds 发明人:HARMER MARK ANDREW; JUNK CHRISTOPHER P; MANZER LEO ERNEST 权利人:DU PONT 摘要:The present invention relates to the synthesis of alkylated aromatic compounds using ionic liquids as the solvent. Alkylated aromatic compounds are synthesized by reacting an aromatic compound with a monoolefin in the presence of an acid catalyst.
专利号:US-7968721-B2 优先权日:2003-01-13 标 题:Large-scale synthesis of selective androgen receptor modulators 发明人:MILLER DUANE D; VEVERKA KAREN A; CHUNG KIWON 权利人:UNIV TENNESSEE RES FOUNDATION 摘要:This invention relates to a process for preparing a selective androgen receptor modulator (SARM) compound represented by the structure of formula I: n nwherein X is O; and T, Z, Y, Q, R and R 1 are defined herein. The process includes coupling between an amide of formula II and a phenol of formula IIIn n n n n n n n n n n nfollowed by a purification step consisting of precipitating the compound of formula (I) in a mixture of alcohol and water alone.
[参考文献]: Agne Tubeleviciute, Et Al. Escherichia Coli Kdud Encodes An Oxidoreductase That Converts Both Sugar And Steroid Substrates. Appl Microbiol Biotechnol. 2014 Jun;98(12):5471-85. [参考文献]: D Couri, Et Al. Toxicity And Metabolism Of The Neurotoxic Hexacarbons N-Hexane, 2-Hexanone, And 2,5-Hexanedione. Annu Rev Pharmacol Toxicol. 1982:22:145-66. [参考文献]: Fuyong Song, Et Al. 2,5-Hexanedione Altered The Degradation Of Low-Molecular-Weight Neurofilament In Rat Nerve Tissues. Food Chem Toxicol. 2012 Dec;50(12):4277-84. [参考文献]: Lei Zhao, Et Al. The Effect Of 2,5-Hexanedione On Myelin Protein Zero Expression, And Its Mitigation Using Ginkgo Biloba Extract. Biomed Environ Sci. 2011 Aug;24(4):374-82. [参考文献]: M Edite Torres, Et Al. Alternative Biomarkers Of N-Hexane Exposure: Characterization Of Aminoderived Pyrroles And Thiol-Pyrrole Conjugates In Urine Of Rats Exposed To 2,5-Hexanedione. Toxicol Lett. 2014 Jan 3;224(1):54-63.
合成参考文献
参考文献:10.1080/14734220500243835 摘要:Manto M, Laute MA, Pandolfo M. Depression of extra-cellular GABA and increase of NMDA-induced nitric oxide following acute intra-nuclear administration of alcohol in the cerebellar nuclei of the rat. Cerebellum. 2005;4(4):230–8. doi: 10.1080/14734220500243835. 参考文献:10.1371/journal.ppat.1002125 摘要:Viarisio D, Mueller-Decker K, Kloz U, Aengeneyndt B, Kopp-Schneider A, Gröne H, Gheit T, Flechtenmacher C, Gissmann L, Tommasino M. E6 and E7 from Beta Hpv38 Cooperate with Ultraviolet Light in the Development of Actinic Keratosis-Like Lesions and Squamous Cell Carcinoma in Mice. PLoS Pathog. 2011 Jul 14;7(7):e1002125. doi: 10.1371/journal.ppat.1002125.