CAS: 91987-74-5; ((1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetrayl)Tetrakis(Methylene))Tetraphosphonic Acid

上下游产品

formaldehyd 1,4,7,10-tetraazacyclododecane tetrahydr°Chloride 1,4,7,10-tetraazacyclododecan (5-)[Eu(1,4,7,10-tetraaz°Cyclododecane-1,4,7,10-tetrakis(methylphosphonic acid(-8H)))](5-) -[Gd(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra(methylphosphonate))]5-

📜1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸置于phosphorus(Iii) Oxide,三氟甲磺酸体系中,化学反应 3.0H,以86.3%的收率获得产物1,4,7,10-四氮杂环十二烷-1,4,7,10-四(甲基膦酸)
参考文献: Method For The Synthesis Of Alpha-Aminoalkylenephosphonic Acid[fr] Procédé De Synthèse D'Acide Alpha-Aminoalkylènephosphonique
标题: Method For The Synthesis Of Alpha-Aminoalkylenephosphonic Acid[fr] Procédé De Synthèse D'Acide Alpha-Aminoalkylènephosphonique
摘要:本发明涉及一种合成α-氨基烯基膦酸或其膦酸酯的新方法,包括以下步骤:通过混合含有一个p原子在氧化态(+111)和另一个p原子在氧化态(+111)或(+v)的p-O-P酸酐基团的化合物,氨基烷基羧酸和酸催化剂来形成反应混合物,其中所述反应混合物中α-氨基烯基羧酸与p-O-P酸酐基团的当量比至少为0.2,并从反应混合物中回收所得的α-氨基烯基膦酸化合物或其酯.

专利信息

专利号:US-2025313580-A1
优先权日:2022-05-19
标题 :Synthesis of fluorosilyl compounds
发明人：FORD THONAN LEE; THOMAS ALEXANDER JAMES FLOY; RAHMAN SABITUR
权利人:BLUE EARTH THERAPEUTICS LTD
摘要:The disclosures herein relate to methods of synthesising a compound of formula (1): n n n n n n n n n n wherein PG, R 2 and R 3 are as defined herein, and the use of said methods in the manufacture of conjugates that bind to PSMA.

专利号:US-8147805-B2
优先权日:2005-01-05
标题:Conjugates for dual imaging and radiochemotherapy: composition, manufacturing, and applications
发明人：YANG DAVID; YU DONGFANG; CHANDA MITHU; AZHDARINIA ALI; OH CHANGSOK; KIM E EDMUND
权利人:YANG DAVID; YU DONGFANG; CHANDA MITHU; AZHDARINIA ALI; OH CHANGSOK; KIM E EDMUND; UNIV T EXAS SYSTEM BOARD OF REGENTS
摘要:Compositions and methods for dual imaging and for dual chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns compounds comprising the structure X 1 —Y—X 2 , wherein Y comprises two or more carbohydrate residues covalently attached to one another, X 1 and X 2 are diagnostic or therapeutic moieties covalently attached to Y, provided that when Y does not comprise a glucosamine residue, X 1 and X 2 are diagnostic moieties. The present invention also concerns methods of synthesis of these compounds, application of such compounds for dual imaging and treatment of hyperproliferative disease, and kits for preparing a radiolabeled therapeutic or diagnostic compound.

专利号:US-2004022857-A1
优先权日:2002-07-31
标 题 :Synthesis of highly conjugated polymers
发明人：UZGIRIS EGIDIJUS E; MOASSER BAHRAM; FISH KENNETH M; SMITH JOANNE F
摘要:Improved methods for forming substituted polymers having a high degree of conjugation include the steps of activating a steric hindrance molecule under conditions that ensure substantially all the steric hindrance molecules are mono-activated and then reacting with a polymer. An improved method for recovering polypeptides substituted with steric hindrance molecules and having an elongate configuration removes impurities and volatiles without achieving complete dryness of the copolymer.

专利号:US-2007196275-A1
优先权日:2001-04-26
标题 :Diagnostic Imaging Compositions, Their Methods Of Synthesis And Use
发明人：LI CHUN; WEN XIAOXIA; WU QING-PING; WALLACE SIDNEY; ELLIS LEE M
权利人:LI CHUN; WEN XIAOXIA; WU QING-PING; WALLACE SIDNEY; ELLIS LEE M
摘要:Conjugate molecules comprising a ligand bonded to a polymer are disclosed. One such conjugate molecule comprises a ligand bonded to a polymer, a chelating agent bonded to the polymer, and a radioisotope chelated to the chelating agent. The conjugate molecules may be useful in detecting and/or treating tumors or biological receptors. These conjugate molecules may be synthesized without the necessity of preactivation of the ligand using an SCN-polymer-chelating agent precursor. Conjugate molecules incorporating an annexin V ligand are particularly useful for visualizing apoptotic cells. Conjugate molecules incorporating a C225 ligand are particularly useful for targeting tumors expressing EGFR.

专利号:WO-2024264053-A2
优先权日:2023-06-23
标 题:Trans-cyclooctene compounds and methods of use in the synthesis of pet probes and radioisotope based therapy

专利号:EP-4526310-A1
优先权日:2022-05-19
标题:Synthesis of fluorosilyl compounds