CAS: 894086-00-1; 5-(Di-Tert-Butylphosphino)-1',3',5'-Triphenyl-1'H-1,4'-Bipyrazole

上下游产品

1',3',5'-三苯基-1'H-1,4'-联吡唑 1-(1,3,5-Triphenyl-1H-Pyrazol-4-yl)-1H-Pyrazole 894085-99-5

2-溴-1,3-二苯基丙烷-1,3-二酮置于正丁基锂,溶剂黄146体系中,用 四氢呋喃,N-甲基吡咯烷酮,正己烷 作为反应溶剂,化学反应 3.5H,反应生成 5-二叔丁基膦-1',3',5'-三苯基-1'h-[1,4']二吡唑
参考文献:Bippyphos配体家族的简化合成和交叉偶联应用
标题:Bippyphos配体家族的简化合成和交叉偶联应用
摘要:我们描述了bippyphos,1的有效制备方法.bippyphos的关键前体5是通过二锅2的一锅溴化反应,然后用吡唑烷基化并与苯肼缩合制备的.5的锂化并用二叔丁基氯膦捕获,得到bippyphos,1.使用这种方法,我们已经制备了bippyphos的几种衍生物,以探测该膦配体家族的结构和活性之间的关系.我们还证明了这些配体在钯催化的胺化反应和其他交叉偶联反应中的效用.
DOI:10.1021/op7002858

专利信息

专利号:US-2024101516-A1
优先权日:2021-01-20
标 题:Synthesis of polyfluorinated aryl and heteroaryl carboxamides
发明人：KADUSKAR RAHUL; BORATE KAILASKUMAR; ADHAV SUYOG; THIRUNAVUKKARASU SARAVANAN; SHINDE HARISH; GOETZ ROLAND
权利人:BASF SE
摘要:The presently claimed invention relates to a process for the preparation of mono-, di-, tri-, fluoro arylamide or hetroarylamide.

专利号:US-9045462-B2
优先权日:2012-08-17
标 题 :Synthesis of an antiviral compound
发明人：EVANS JARED WAYNE; FUJIMORI SHINJI; HUYNH GRACE M; LIU QI; TERESK MARTIN GERALD
权利人:GILEAD SCIENCES INC
摘要:The present disclosure provides processes for the preparation of a compound of Formula I: n nwhich is useful as an antiviral agent. The disclosure also provides compounds that are synthetic intermediates to compounds of formula.

专利号:US-2025313551-A1
优先权日:2022-12-15
标题 :Process for the preparation of a quinazolinone derivative
发明人：DOTT PASCAL JEAN CLAUDE; FANTASIA SERENA MARIA; GUILLEMOT-PLASS MAUD; KALDRE DAINIS; LARI GIACOMO MARCO; MODOLO-CHELLAT ISABELLE GEORGETTE HUGUETTE; SEDELMEIER JOERG MATHIAS; TROKOWSKI SEBASTIAN
权利人:HOFFMANN LA ROCHE
摘要:The present invention relates to a new process for the preparation of (3R)—N-[2-cyano-4-fluoro-3-(3-methyl-4-oxo-quinazolin-6-yl)oxy-phenyl]-3-fluoro-pyrrolidine-1-sulfonamide, as well as to a novel intermediate useful for the synthesis of said compound at large scale.

专利号:US-2022056025-A1
优先权日:2018-09-25
标 题:Synthesis of pyrido[2,3-d]pyrimidin-7(8h)-ones
发明人：BROWN ADAM ROSS; DESROSIERS JEAN-NICOLAS; DUAN SHENGQUAN; HAWKINS JOEL MICHAEL; HAYWARD CHERYL MYERS; MALONEY MARK THOMAS; MONFETTE SEBASTIEN; PERFECT HAHDI HAKIMIOUN; WIDLICKA DANIEL WILLIAM
权利人:PFIZER
摘要:This invention relates to novel methods to prepare substituted pyrido[2,3-d]pyrimidin-7(8H)-ones, and salts and stereoisomers thereof, as well as intermediates useful for the preparation of such compounds.

专利号:US-8927741-B2
优先权日:2012-08-17
标 题 :Synthesis of an antiviral compound
发明人：WATKINS WILLIAM JOHN; LIU QI
权利人:GILEAD SCIENCES INC
摘要:The present disclosure provides a processes for the preparation of a compound of Formula I: n nwhich is useful as an antiviral agent. The disclosure also provides compounds that are synthetic intermediates to compounds of Formula I.

专利号:US-12202782-B2
优先权日:2020-11-19
标 题:Processes and intermediates for preparing MCL1 inhibitors
发明人：DIXON DARRYL D; ISCHAY MICHAEL A; JOHNSON TREVOR C; MERIT JEFFREY E; REGENS CHRISTOPHER S; STANDLEY ERIC A; STEINHUEBEL DIETRICH P
权利人:GILEAD SCIENCES INC
摘要:The present disclosure relates to methods and intermediates for the synthesis of certain compounds that inhibit MCL1, for use in the treatment of cancers.