CAS: 84477-04-3; 2,3,4-Trifluoropyridine

相似化合物

700-16-3 837365-04-5 1513-66-2

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CAS号851178-99-9 4-氯-2,3-二氟吡啶 | CAS号89402-43-7 2,3-二氟-5-氯吡啶 | CAS号110-86-1 吡啶 | CAS号1513-66-2 2,3－二氟吡啶

📜2,3-二氟-5-氯吡啶置于palladium On Activated Charcoal Potassium Fluoride,正丁基锂,甲酸铵,四甲基氯化铵,溶剂黄146体系中,用 四氢呋喃,正己烷,二甲基亚砜 作为反应溶剂,化学反应 8.0H,反应生成 2,3,4-三氟吡啶
参考文献:从聚卤代吡啶中除去氟并将氟引入到聚卤代吡啶中:亲核性戊烯取代反应.
标题:从聚卤代吡啶中除去氟并将氟引入到聚卤代吡啶中:亲核性戊烯取代反应.
摘要:从六个工业上可获得的氟化吡啶开始,开发了一种方便的途径来获取所有三个四氟吡啶(2-4),所有六个三氟吡啶(5-10)和五个非商业性二氟吡啶(11-14和16).用于从多氟吡啶中选择性除去氟的方法是通过金属或复合氢化物进行还原,并用肼进行位点选择性置换,然后进行脱氢-脱重氮或脱氢氯化-脱重氮.为了引入额外的氟原子,在进行氯/氟置换过程之前,将合适的前体金属化和氯化.
DOI:10.1002/chem.200400837

专利信息

专利号:US-2012177593-A1
优先权日:2009-07-20
标 题 :Synthesis of dendrimer conjugates
发明人：BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH
权利人:BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH; UNIV MICHIGAN
摘要:The present invention relates to novel methods of synthesis of therapeutic and diagnostic dendrimers. In particular, the present invention is directed to novel dendrimer conjugates, novel methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer, inflammatory disease) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer conjugates of the present invention may further comprise at least two different components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. Furthermore, the novel synthesis methods of certain embodiments of the present invention provide significant advantages with regard to total reaction time and simplicity.

专利号:US-6264962-B1
优先权日:1997-12-19
标 题:Use of cinnamic acid or of at least one of its derivatives in a cosmetic composition
发明人：BRETON LIONEL; GIRERD FLORENCE; RENAULT BEATRICE
权利人:OREAL
摘要:The invention relates to the use of cinnamic acid, or of at least one of its derivatives, in a cosmetic composition as an agent for promoting the synthesis of the skin's total lipids. n The invention also relates to a cosmetic composition comprising an effective amount of cinnamic acid or of at least one of its derivatives.

专利号:US-6660283-B2
优先权日:1997-12-19
标 题 :Use of cinnamic acid, or of at least one of its derivatives in a cosmetic composition
发明人：BRETON LIONEL; GIRERD FLORENCE; RENAULT BEATRICE
权利人:OREAL
摘要:The invention relates to the use of cinnamic acid, or of at least one of its derivatives, in a cosmetic composition as an agent for promoting the synthesis of the skin's total lipids.The invention also relates to a cosmetic composition comprising an effective amount of cinnamic acid or of at least one of its derivatives.

专利号:US-9220714-B2
优先权日:2006-03-16
标 题 :Nitrofuran compounds for the treatment of cancer and angiogenesis
发明人：SAULNIER SHOLLER GISELLE L; SWAMY NARASIMHA; KALKUNTE STAYAN; SINGH RAKESH K; BRARD LAURENT; KIM KYU KWANG
权利人:WOMEN AND INFANTS HOSPITAL OF RHODE ISLAND; UNIV BROWN; WOMEN AND INFANTS HOSPITAL RHODE ISLAND
摘要:The invention is directed to the synthesis and use of nitrofuran compounds, especially Nifurtimox, as medicaments to treat cancer, especially neuroblastoma, and to inhibit angiogenesis. The invention also provides compositions, unit dosage forms, and kits comprising the compounds.

专利号:WO-2024146880-A1
优先权日:2023-01-03
标题:Fluoro-oxysterols positron emission tomography (pet) radiotracers
发明人：POIROT MARC; COURBON FRÉDÉRIC; SAMADI MOHAMMAD; DE MEDINA PHILIPPE; SILVENTE POIROT SANDRINE; BRILLOUET SÉVERINE
权利人:INST NAT SANTE RECH MED; CENTRE NAT RECH SCIENT; UNIV TOULOUSE III – PAUL SABATIER; INST CLAUDIUS REGAUD; CT HOSPITALIER UNIVERSITAIRE TOULOUSE; UNIV DE LORRAINE
摘要:Radiopharmaceuticals-based biomedical imaging plays a growing role in cancer management, including diagnosis, tumor staging and aggressiveness and treatment monitoring. Even though 18Fluoro-2-deoxy glucose and 18Fluoroestradiol are currently used for some types of breast cancer, a need remains to develop other candidate compounds which are useful as radiotracers in a different/ broader range of cancer types. Thus, it is described a family of 18F radiolabeled compounds of formula (I) (wherein one of R2, R4, R5, R6, R7 and R12 is 18F) for use as Positron Emission Tomography imaging agents for the detection of cancers and metastatic sites thereof, as well as for monitoring and predicting the efficacy of a cancer treatment, wherein the cancer is associated to cholesterol-5,6- epoxide hydrolase and/or lip-hydroxy steroid dehydrogenase type (2) overexpression. To overcome the issues linked to the lifetime of the radioisotope 18F and, to ensure an effective synthesis of the 18F radiolabeled compounds of formula (I), a group of novel intermediate compounds in the synthesis thereof is also described.

专利号:US-2015352230-A1
优先权日:2013-01-11
标 题:Synthesis and isolation of dendrimer based imaging systems
发明人：MULLEN DOUGLAS GURNETT; BAKER JR JAMES R; BANASZAK HOLL MARK M; HUANG BAOHUA; DOUGHERTY CASEY; BALL JACK
权利人:UNIV MICHIGAN
摘要:The present invention relates to novel methods of synthesis and isolation of antibodies conjugated with modular dendrimer nanoparticles. In particular, the present invention is directed to antibodies conjugated with novel modular dendrimer nanoparticles having precise numbers of imaging agents, methods of synthesizing the same, compositions comprising such antibodies conjugated with such modular dendrimer nanoparticles, as well as systems and methods utilizing the conjugates (e.g., in imaging settings) (e.g., in diagnostic and/or therapeutic settings) (e.g., for the delivery of therapeutics, imaging, and/or targeting agents).