CAS: 721958-74-3; 3-Ethyl 5-Methyl 2,6-Bis((2-Aminoethoxy)Methyl)-4-(2-Chlorophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate
该化合物是合成有机化合物,其特征是复杂的分子结构,包括一个环和多种功能组.该化合物有两种碳盒状物组,它们有助于其作为药剂的潜力,可能影响其溶解性和再活性.氨基氧侧链的存在表明氢与生物目标结合和相互作用的潜力,加强其生物活动.环上的乙基和甲基亚基元素可能会影响化合物的脂性性和总体药用性.此外,氯盒体组可产生特定的电子效应,影响化合物的再活性和与受体或酶的相互作用.
- 英文名称3-Ethyl 5-Methyl 2,6-Bis((2-Aminoethoxy)Methyl)-4-(2-Chlorophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate
- 中文名称二(氨基乙氧基)氨氯地平
- IUPAC名称3-ethyl 5-methyl 2,6-bis((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- 其它别名Bis(Aminoethoxy) Amlodipine; 2,6-Bis[(2-Aminoethoxy)Methyl]-4-(2-Chlorophenyl)-1,4-Dihydro-3,5-Pyridinedicarboxylic Acid 3-Ethyl 5-Methyl Ester; Ethyl Methyl 2,6-Bis[(2-Aminoethoxy)Methyl]-4-(2- Chlorophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate; 3-Ethyl 5-Methyl 2,6-Bis((2-Aminoethoxy)Methyl)-4-(2-Chlorophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate Dihydrochloride; Amlodipine Impurity- C(Ep); Amlodipine Impurity C; Ethyl Methyl (4Rs)-2,6-Bis[(2-Aminoethoxy)Methyl]-4-(2-Chlorophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate Dihydrochloride; Amlodipine Ep Impurity C
- CAS编号721958-74-3
- MFCD编号:MFCD22683767
- FDA UNII编号:VQZ6PKV3KH
- 分子式:C22H30ClN3O6分子量:467.95
- 产品CID: 1708420
- 产品分类分析化学 → 标准品 → 药典标准品和杂质标准品
物理性质
MSDS等安全信息
上下游产品
ethylmethyl-2,6-bis-[(2-phthalimidoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate合成工艺路线路线简述
📜Ethylmethyl-2,6-Bis-[(2-Phthalimidoethoxy)Methyl]-4-(2-Chlorophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate置于肼体系中,用 甲醇,甲苯 作为反应溶剂,化学反应 18.0H,以66%的收率获得产物二(氨基乙氧基)氨氯地平
参考文献: Isolation Of Dihydropyridine Derivative And Preparation Salts Thereof[fr] Isolation De Derive De Dihydropyridine Et Sels De Preparation De Celui-Ci
标题: Isolation Of Dihydropyridine Derivative And Preparation Salts Thereof[fr] Isolation De Derive De Dihydropyridine Et Sels De Preparation De Celui-Ci
摘要:该化合物的标题化合物通过结晶过程纯化并转化为其药用可接受的盐.结晶过程影响氨氯地平盐的稳定性和纯度.所有已知杂质和在氨氯地平盐合成过程中形成的一种未知杂质均被分离,表征和合成.开发了一种新方法,允许在单个色谱图中定量HPLC分析氨氯地平盐的所有相关杂质.
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2902600000-乙苯
2902700000-异丙基苯 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:WO-2004058711-A1
优先权日:2002-12-30
标 题 :Isolation of dihydropyridine derivative and preparation salts thereof
发明人：ASLAN TUNCER; ADIYAMAN MUSTAFA; YURDAKUL AYCIL; SAHPAZ FILIZ; OZARSLAN EVREN A; GUNER DIDEM; RIDVANOGLU NURTEN
权利人:EOS ECZACIBASI OZGUN KIMYASAL; ASLAN TUNCER; ADIYAMAN MUSTAFA; YURDAKUL AYCIL; SAHPAZ FILIZ; OZARSLAN EVREN A; GUNER DIDEM; RIDVANOGLU NURTEN
摘要:The title compound is isolated in pure form by using a crystallization process and converted to its pharmaceutically acceptable salts. The crystallization process affects stability and purity of the amlodipine salts. All known impurities and one unknown impurity, which forms during the synthesis of the amlodipine salts, were isolated, characterized, and synthesized. A new method allowing the quantitative HPLC analysis of all related impurities of amlodipine salts in a single chromatogram was developed.
