CAS: 621-29-4; 1-Isocyanato-3-Methylbenzene

上下游产品

CAS号32315-10-9 三光气 | CAS号108-44-1 3-甲基苯胺 | CAS号201230-82-2 carbon monoxide | CAS号99-08-1 3-硝基甲苯 | CAS号618-47-3 间甲基苯甲酰胺 | CAS号63-99-0 3-甲基苯基脲 | CAS号75-44-5 光气 | CAS号620-50-8 1,3-bis(3-methy... | CAS号503-38-8 氯甲酸三氯甲酯 | CAS号590-28-3 氰酸钾 | CAS号29209-14-1 2-Methyl-N-(3-m... | CAS号621-30-7 间甲苯异硫氰酸酯 | CAS号1043907-98-7 1-(1-([1,2,4]噻唑... | CAS号620-50-8 1,3-bis(3-methy... | CAS号13684-63-4 甜菜宁 | CAS号32496-22-3 Carbamic acid,N... | CAS号325850-26-8 1-(3-氯苯基)-3-(1,... | CAS号71532-35-9 3-(3-methylphen... | CAS号7342-80-5 1,3-bis(3-methy... | CAS号7399-77-1 Propanoic acid,...

间甲苯脲置于盐酸,水,Sodium Nitrite体系中,化学反应生成 异氰酸间甲苯酯
参考文献:Haager; Doht,Monatshefte Fur Chemie,1906,Vol. 27,P. 273
标题:Haager; Doht,Monatshefte Fur Chemie,1906,Vol. 27,P. 273

专利信息

专利号:US-8188113-B2
优先权日:2006-09-14
标 题 :Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
权利人:FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C; DECIPHERA PHARMACEUTICALS INC
摘要:The present invention relates to novel dihydropyridopyrimidinyl, dihydronaphthyridinyl, and related compounds which are kinase inhibitors and modulator useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

专利号:US-8487094-B2
优先权日:2008-07-25
标题 :Synthesis of inhibitors of 11β-hydroxysteroid dehydrogenase type 1
发明人：FANDRICK KEITH R; GAO JOE JU; LI WENJIE; LU ZHI-HUI; ZHANG YONGDA
权利人:FANDRICK KEITH R; GAO JOE JU; LI WENJIE; LU ZHI-HUI; ZHANG YONGDA; BOEHRINGER INGELHEIM INT
摘要:Disclosed are syntheses of 11β-HSD1 inhibitors and corresponding intermediates that are promising for the treatment of a variety of disease states including diabetes, metabolic syndrome, obesity, glucose intolerance, insulin resistance, hyperglycemia, hypertension, hypertension-related cardiovascular disorders, hyperlipidemia, deleterious gluco-corticoid effects on neuronal function (e.g. cognitive impairment, dementia, and/or depression), elevated intra-ocular pressure, various forms of bone disease (e.g., osteoporosis), tuberculosis, leprosy (Hansen's disease), psoriasis, and impaired wound healing (e.g., in patients that exhibit impaired glucose tolerance and/or type 2 diabetes).

专利号:WO-0078740-A1
优先权日:1999-06-23
标 题 :Solid-supported initiators and functional polymers for use in organic synthesis and combinatorial chemistry
发明人：HARIKRISHNAN LALGUDI SANKARAN; HODGES JOHN COOKE; LINDSLEY CRAIG WILLIAM
权利人:WARNER LAMBERT CO; HARIKRISHNAN LALGUDI SANKARAN; HODGES JOHN COOKE; LINDSLEY CRAIG WILLIAM
摘要:Solid-supported initiator and functional polymers are described as well as methods for the preparation and use in solution phase, solid-phase organic synthesis, and combinational chemistry including use as initiators of solid-supported free-radical polymerization, as solid-supported scavengers for purification of crude solution phase reaction mixtures, as a stationary phase for solid-phase organic synthesis, and as solid-supported reagents in solution-phase organic synthesis.

专利号:WO-2009017671-A1
优先权日:2007-07-26
标题 :Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1

专利号:US-2010256363-A1
优先权日:2007-07-26
标题 :SYNTHESIS OF INHIBITORS OF 11ß-HYDROXYSTEROID DEHYDROGENASE TYPE 1

专利号:CN-116137864-A
优先权日:2020-07-23
标 题:Synthesis of linear polyoxazolidinones using uretdiones as diisocyanate component