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合成工艺路线路线简述

  • 合成目标产物 Myristicin 主要起始原料 Eugenol
  • (文献来源)合成步骤主要原料 Eugenol
📜丁香酚置于吡啶,正己胺,双氧水,Potassium Carbonate,Sodium Hydroxide体系中,用 水,丙酮 作为反应溶剂,化学反应 27.5H,反应生成 肉豆蔻醚
参考文献: Synthesis Of Elemicin And Topical Analgesic Compositions[fr] Synthèse D'élémicine Et Compositions Analgésiques Topiques
标题: Synthesis Of Elemicin And Topical Analgesic Compositions[fr] Synthèse D'élémicine Et Compositions Analgésiques Topiques
摘要:本发明涉及对艾利美辛及其异构形式的合成,以及它们在局部止痛制剂中的应用,包括用于牙科和兽医用途.各种组合包括凝胶,膜,敷料,蛀牙填充凝胶,具有止痛和/或抗真菌特性.

海关参考信息

专利信息


专利号:US-2015057366-A1
优先权日:2012-03-05
标题 :Synthesis of elemicin and topical analgesic compositions
发明人:LA GRANGE MARTIN JAMES
权利人:LA GRANGE MARTIN JAMES
摘要:The present invention is directed to the synthesis of elemicin and its isomeric form, and their use in topical analgesic formulations, including for dental and veterinary use. Various compositions include gels, films, dressings, cavity filling gels, having analgesic and/or antifungal properties.

专利号:WO-2024130393-A1
优先权日:2022-12-21
标 题 :Nanoparticle and method of synthesis thereof
发明人:MOSKOVCHENKO SVITLANA
权利人:MOSKOVCHENKO SVITLANA
摘要:The present technology relates to nanoparticles, compositions comprising said nanoparticles, and methods of synthesis of said nanoparticles; wherein the nanoparticles comprise a metal nanoparticle core, a first coating of amphiphilic molecules, and a second coating of essential oil, essential oil primary constituent, or both, which combine the antimicrobial properties of metal nanoparticles, amphiphilic molecules, and essential oil or essential oil primary constituents.

专利号:US-10189951-B2
优先权日:2014-04-25
标题 :Aliphatic polyimides from a 1:2 molar ration of diamine and unsaturated monoanhydride or unsaturated diacid
发明人:DUAN YANNAN; AVAKIAN ROGER W
权利人:POLYONE CORP
摘要:Aliphatic polyimides are synthesized by a 2:1 molar ratio reaction of an unsaturated monoanhydride or an unsaturated diacid with a diamine. Bio-derived monomers are particularly useful in the synthesis of the aliphatic polyimides.

专利号:US-2017044320-A1
优先权日:2014-04-25
标题 :Aliphatic polyimides from a 1:1 molar ratio of diamine and unsaturated monoanhydride or unsaturated diacid
发明人:DUAN YANNAN; AVAKIAN ROGER W
权利人:POLYONE CORP
摘要:Aliphatic polyimides are synthesized by a 1:1 molar ratio reaction of an unsaturated monoanhydride or an unsaturated diacid with a diamine. Bio-derived monomers are particularly useful in the synthesis of the aliphatic polyimides.

专利号:US-7329767-B2
优先权日:2003-10-03
标 题:Conjugated dienamides, methods of production thereof, compositions containing same and uses thereof
发明人:DEWIS MARK L; JOHN THUMPLASSERIL V; ECKERT MARKUS A; COLSTEE JAN HERMAN; DA COSTA NEIL C; PEI TAO
权利人:INT FLAVORS & FRAGRANCES INC
摘要:Described are mixtures of at least four of the alkadienamides defined according to the structure: n nwherein R represents C 1 -C 2 n-alkyl; R 1 is 2-methyl-1-propyl and R 2 is hydrogen, or R 1 and R 2 taken together is a moiety having the formulan n nwherein n is 4 or 5, or compositions containing substantial concentrations of such mixtures, prepared according to novel processes: (a) extraction of a ground substantially dried fruit of one of the Piper species, Piper longum Linn or Piper peepuloides ; (b) natural product-forming synthesis; or (c) synthetic product-forming synthesis. Also described are uses of the thus-formed products for augmenting, enhancing or imparting an aroma, taste, chemesthetic effect and/or antibacterial effect in or to a consumable material and/or in the oral cavity and/or on the mammalian epidermis.

专利号:US-8007841-B2
优先权日:2003-10-03
标 题 :Conjugated dienamides, methods of production thereof, compositions containing same and uses thereof
发明人:JOHN THUMPLASSERIL V; ECKERT MARKUS A; DEWIS MARK L; COLSTEE JAN HERMAN; DA COSTA NEIL C
权利人:INT FLAVORS & FRAGRANCES INC
摘要:Described are mixtures of at least four of the alkadienamides defined according to the structure: n nwherein R represents C 1 -C 2 n-alkyl; R 1 is 2-methyl-1-propyl and R 2 is hydrogen, or R 1 and R 2 taken together is a moiety having the formula —(CH 2 ) n —, wherein n is 4 or 5, or compositions containing substantial concentrations of such mixtures, prepared according to novel processes: (a) extraction of a ground substantially dried fruit of one of the Piper species, Piper longum Linn or Piper peepuloides ; (b) natural product-forming synthesis; or (c) synthetic product-forming synthesis. Also described are uses of the thus-formed products for augmenting, enhancing or imparting an aroma, taste, chemesthetic effect and/or antibacterial effect in or to a consumable material and/or in the oral cavity and/or on the mammalian epidermis.

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主要参考文献


1: Yang AH, He X, Chen JX, He LN, Jin CH, Wang LL, Zhang FL, An LJ. Identification and characterization of reactive metabolites in myristicin-mediated mechanism-based inhibition of CYP1A2. Chem Biol Interact. 2015 Jul 25;237:133-40. doi: 10.1016/j.cbi.2015.06.018. Epub 2015 Jun 16. doi: 10.1016/j.cbi.2014.04.014. Epub 2014 Apr 29. Epub 2012 Aug 15.
4: Lee JY, Park W. Anti-inflammatory effect of myristicin on RAW 264.7 macrophages stimulated with polyinosinic-polycytidylic acid. Molecules. 2011;16(8):7132-42. pii: bcr2013203000. doi: 10.1136/bcr-2013-203000.
6: Leiter E, Hitchcock G, Godwin S, Johnson M, Sedgwick W, Jones W, McCall S, Ceremuga TE. Evaluation of the anxiolytic properties of myristicin, a component of nutmeg, in the male Sprague-Dawley rat. AANA J. 2011 Apr;79(2):109-14. doi: 10.1016/j.fct.2012.04.013. Epub 2012 Apr 16. doi: 10.1016/j.fct.2013.06.058. Epub 2013 Jul 8. doi: 10.1016/j.fct.2010.11.013. Epub 2010 Nov 16. Review. doi: 10.1016/j.ibmb.2008.03.013. Epub 2008 Apr 9. doi: 10.1007/s00204-016-1752-5. Epub 2016 Jun 22.

合成参考文献


摘要:Journal of Agricultural and Food Chemistry., 30(563), 1982 []
摘要:Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington, DC: Amer Chem Soc pp. 7-4, 7-5, 8-12 (1990)
摘要:
摘要:
摘要:Franke C et al; Chemosphere 29: 1501-14 (1994)
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