📜1-碘戊烷置于silver Fluoride体系中,化学反应生成 1-氟戊烷 参考文献:The Electric Moments Of Some Aliphatic Fluorides,Cyanides And Amines 标题:The Electric Moments Of Some Aliphatic Fluorides,Cyanides And Amines 摘要: DOI:10.1021/ja01194A076
专利号:US-5545568-A 优先权日:1992-09-14 标题:Solid phase and combinatorial synthesis of compounds on a solid support 发明人:ELLMAN JONATHAN A 权利人:UNIV CALIFORNIA 摘要:Methods, compositions, and devices for synthesizing combinatorial libraries of various useful compounds, such as benzodiazepines, prostaglandins, β-turn mimetics and glycerol-derived drugs is described. In order to expediently synthesize such combinatorial libraries of derivatives based upon these core structures, a general methodology for the solid phase synthesis of these derivatives is also provided. This disclosure thus also describes an important extension of solid phase synthesis methods to nonpolymeric organic compounds.
专利号:US-6156922-A 优先权日:1995-12-28 标题 :Method for the synthesis of an aromatic derivative ortho-disubstituted by a halogen atom other than fluorine and by a cyano group 发明人:RUSSELL JAMES; GILBERT LAURENT; MAESTRO JEAN PIERRE 权利人:RHODIA CHIMIE SA 摘要:PCT No. PCT/FR96/02100 Sec. 371 Date Sep. 15, 1998 Sec. 102(e) Date Sep. 15, 1998 PCT Filed Dec. 27, 1996 PCT Pub. No. WO97/24318 PCT Pub. Date Jul. 10, 1997The present invention relates to a method for the synthesis of a halogen substituted aryl nitrile, where the halogens are selected from Cl, Br, or I, by reacting an aryl dihalide with a halogen/fluoride exchange reactant to produce a halogen substituted aryl fluoride which is then reacted with a fluoride/cyanide exchange reactant to produce the halogen substituted aryl nitrile.
专利号:EP-1960423-B1 优先权日:2004-12-30 标 题:Synthesis of peptide t-20 using peptide intermediate fragments 发明人:HAN YEUN-KWEI; JOHNSTON DAVID A; KHATRI HIRALAL N 权利人:HOFFMANN LA ROCHE 摘要:Methods for the solid phase synthesis of T-20 peptides and peptide intermediates, in particular methods involving synthesizing T-20 peptide intermediates at low loading factors to produce products having excellent purity and yield.
专利号:US-7767826-B2 优先权日:2007-10-05 标题 :Process for the synthesis of L-(+)-ergothioneine 发明人:TRAMPOTA MIROSLAV 权利人:PHARMATECH INTERNATIONAL INC 摘要:This invention relates to a novel process for the preparation of optically pure L-(+)-ergothioneine. The process for the chemical synthesis of L-ergothioneine comprises steps which consist of reacting L-histidine alkyl ester with an acid halide, chloroformate or pyrocarbonate in the presence of a base, hydrolysis of the alkyl-(S,Z)-2,4,5-triamidopent-4-enoate to obtain a (S)-alkyl 2,5-diamido-4-oxopentanoate, acid catalyzed hydrolysis of the (S)-alkyl 2,5-diamido-4-oxopentanoate followed by reaction with a metal thiocyanate to obtain the thiohistidine, protection of the sulfur of thiohistidine as the tert-butyl thioether, dialkylation of the primary amine to obtain a tertiary amine, quaternization of the tertiary amine, and removal of the protecting group to obtain the desired (S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trialkylammonio)propanoate (I). This process affords a better yield and is capable of practical application at large scale.
专利号:US-6395937-B2 优先权日:2000-05-25 标题:Synthesis of diacyl peroxide in carbon dioxide 发明人:BROTHERS PAUL DOUGLAS; KIPP BRIAN EDWARD; NOELKE CHARLES JOSEPH; USCHOLD RONALD EARL; WHELAND ROBERT CLAYTON 权利人:DU PONT 摘要:This invention relates to a process for the synthesis of diacyl peroxide by contacting acyl halide and peroxide complex in liquid or supercritical carbon dioxide.
专利号:EP-1833843-B1 优先权日:2004-12-30 标 题:Synthesis of peptide t-20 using peptide intermediate fragments 发明人:HAN YEUN-KWEI; JOHNSTON DAVID A; KHATRI HIRALAL N 权利人:HOFFMANN LA ROCHE 摘要:Methods for the solid phase synthesis of T-20 peptides and peptide intermediates, in particular methods involving synthesizing T-20 peptide intermediates at low loading factors to produce products having excellent purity and yield.
参考文献:10.1186/s43094-024-00587-4 摘要:Hatem S, Mohammed D, Ezzat N. Nanotechnology-based strategies overcoming the challenges of retinoblastoma: a comprehensive overview and future perspectives. Futur J Pharm Sci. 2024 Feb 09;10(1). doi: 10.1186/s43094-024-00587-4.