CAS: 57432-61-8; Methyl Ergonovine Maleate Salt

化学文摘社编号为57432-61-8.,其体外腺素作为强效子宫刺激剂,促进收缩,便利胎盘的排出.该物质通常通过肌肉内或口腔途径经管,视临床情况而定.其半衰期相对较短,需要仔细监测剂量和时间.常见副作用可能包括高血压,恶心和头痛,反映其血管抑制性能.由于其药效效应,甲状腺素在高血压或心血管疾病患者中是受感染的,其行动机制涉及血清素和肾脏内感应激素的抗体活动,导致子宫腔基质升高,并减少分娩期间和产后的血损.与任何药物一样,使用甲状物在医疗监督下确保安全性和药效至关重要.

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欧盟法规

ECHA物质C&L通报REACH预注册

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    海关参考信息

    专利信息


    专利号:US-3968112-A
    优先权日:1974-08-02
    标 题:Synthesis of penniclavine and elymoclavine
    发明人:KORNFELD EDMUND C; BACH NICHOLAS J
    权利人:LILLY CO ELI
    摘要:Synthesis of penniclavine and of elymoclavine, intermediates useful therein, and novel compounds producible therefrom.

    专利号:US-4082753-A
    优先权日:1976-02-17
    标题:Penniclavine acetonide
    发明人:KORNFELD EDMUND C; BACH NICHOLAS J
    权利人:LILLY CO ELI
    摘要:Synthesis of penniclavine and of elymoclavine, intermediates useful therein, and novel compounds producible therefrom.

    专利号:US-4054567-A
    优先权日:1975-08-11
    标 题:6-Methyl-8β-hydroxymethyl-8-γ-substituted-9-ergolene compounds
    发明人:KORNFELD EDMUND C; BACH NICHOLAS J
    权利人:LILLY CO ELI
    摘要:Synthesis of penniclavine and of elymoclavine, intermediates useful therein, and novel compounds producible therefrom.

    专利号:CA-1051879-A
    优先权日:1974-08-02
    标题 :Synthesis of elymoclavine and derivatives

    专利号:CA-1042423-A
    优先权日:1974-08-02
    标题 :Synthesis of penniclavine and derivatives

    专利号:US-2014315720-A1
    优先权日:2012-10-24
    标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
    发明人:FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
    权利人:CELANESE ACETATE LLC
    摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.
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    主要参考文献


    1: Bateman BT, Huybrechts KF, Hernandez-Diaz S, Liu J, Ecker JL, Avorn J. Methylergonovine maleate and the risk of myocardial ischemia and infarction. Am J Obstet Gynecol. 2013 Nov;209(5):459.e1-459.e13. doi: 10.1016/j.ajog.2013.07.001. Epub 2013 Jul 11.
    2: Saper JR, Evans RW. Oral methylergonovine maleate for refractory migraine and cluster headache prevention. Headache. 2013 Feb;53(2):378-81. doi: 10.1111/head.12033. Review. Spanish. Review.

    合成参考文献


    参考文献:10.1007/s00404-012-2671-1
    摘要:Anvaripour A, Shahryari H, Ahmadi S, Ghasemi S, Mirzaei K. Comparison the effects of oxytocin and methylergonovine in elective caesarean section under spinal anesthesia. Archives of Gynecology and Obstetrics. 2012 Dec 19;287(5):979–83. doi: 10.1007/s00404-012-2671-1.
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