专利号:US-3968112-A 优先权日:1974-08-02 标 题:Synthesis of penniclavine and elymoclavine 发明人:KORNFELD EDMUND C; BACH NICHOLAS J 权利人:LILLY CO ELI 摘要:Synthesis of penniclavine and of elymoclavine, intermediates useful therein, and novel compounds producible therefrom.
专利号:US-4082753-A 优先权日:1976-02-17 标题:Penniclavine acetonide 发明人:KORNFELD EDMUND C; BACH NICHOLAS J 权利人:LILLY CO ELI 摘要:Synthesis of penniclavine and of elymoclavine, intermediates useful therein, and novel compounds producible therefrom.
专利号:US-4054567-A 优先权日:1975-08-11 标 题:6-Methyl-8β-hydroxymethyl-8-γ-substituted-9-ergolene compounds 发明人:KORNFELD EDMUND C; BACH NICHOLAS J 权利人:LILLY CO ELI 摘要:Synthesis of penniclavine and of elymoclavine, intermediates useful therein, and novel compounds producible therefrom.
专利号:CA-1051879-A 优先权日:1974-08-02 标题 :Synthesis of elymoclavine and derivatives
专利号:CA-1042423-A 优先权日:1974-08-02 标题 :Synthesis of penniclavine and derivatives
专利号:US-2014315720-A1 优先权日:2012-10-24 标 题 :Polysaccharide ester microspheres and methods and articles relating thereto 发明人:FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY 权利人:CELANESE ACETATE LLC 摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.
1: Bateman BT, Huybrechts KF, Hernandez-Diaz S, Liu J, Ecker JL, Avorn J. Methylergonovine maleate and the risk of myocardial ischemia and infarction. Am J Obstet Gynecol. 2013 Nov;209(5):459.e1-459.e13. doi: 10.1016/j.ajog.2013.07.001. Epub 2013 Jul 11. 2: Saper JR, Evans RW. Oral methylergonovine maleate for refractory migraine and cluster headache prevention. Headache. 2013 Feb;53(2):378-81. doi: 10.1111/head.12033. Review. Spanish. Review.
合成参考文献
参考文献:10.1007/s00404-012-2671-1 摘要:Anvaripour A, Shahryari H, Ahmadi S, Ghasemi S, Mirzaei K. Comparison the effects of oxytocin and methylergonovine in elective caesarean section under spinal anesthesia. Archives of Gynecology and Obstetrics. 2012 Dec 19;287(5):979–83. doi: 10.1007/s00404-012-2671-1.