CAS: 56558-17-9; 2,3',4,4',6-Pentachloro-1,1'-Biphenyl

该化合物是多氯联苯(PCB)家族的成员,这是合成有机化学品,以其环境持久性和潜在毒性而著称,该化合物由两个双联环组成,五氯原子在特定位置被替换,显著改变了其物理和化学特性,在室温和低挥发性方面通常是固态的,在室温下具有低挥发性;氯原子的存在会增加其缺水性,使其在水中溶解性不好,但在有机溶剂中更易溶解. 2,4,4',4',6-五氯联苯具有稳定性和耐降解性,有助于其在环境和生物体中的积累.由于其潜在的健康风险,包括内分泌干扰和致癌影响,许多国家对其使用进行了严格的管制或禁止.目前正在开展监测和补救工作,以应对多氯联苯对环境的影响,包括这一特定化合物.

英文名称2,3',4,4',6-Pentachloro-1,1'-Biphenyl
中文名称2,3',4,4',6-五氯-1,1'-联苯
IUPAC名称1,3,5-trichloro-2-(3,4-dichlorophenyl)benzene
其它别名2,3',4,4',6-五氯联苯; 2,3',4,4',6-Pentachlorobiphenyl
CAS编号56558-17-9
MFCD编号:MFCD00152726
FDA UNII编号:YRA124HZZL
分子式:C12H5Cl5分子量:326.43
产品CID: 1539128
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
产品信息参考;;;;
InChIKey: OAEQTHQGPZKTQP-UHFFFAOYSA-N
1S/C12H5Cl5/c13-7-4-10(16)12(11(17)5-7)6-1-2-8(14)9(15)3-6/h1-5H
计算化学: 氢键受体数*氢键供体数0可旋转键数1

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)

上下游产品

1,3,5-trichloro-2-iodobenzene 3,4-dichloroiodobenzene 1,3,6,7-tetrachlorodibenzofuran 1,3,7,8-tetrachlorodibenzofuran

合成工艺路线路线简述

📜1-碘-2,4,6-三氯苯,3,4-二氯碘苯置于铜体系中,用 N,N-二甲基甲酰胺作为反应溶剂,化学反应生成 2,3',4,4',6-五氯联苯
参考文献:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
标题:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
摘要:Physical,Spectral And Chromatographic Data For All 209 Individual Pcb Congeners Is Presented. The Individual Congeners Were Synthesized And Then Isolated And Purified. Recent Emphasis On The Source Of The Toxicity Of Commercial Pcb Formulations Has Increased The Need For A Complete Set Of The Pcb Congeners. Through The Use Of Two Capillary Gc Columns: 40% octadecyl/ 15% Phenyl Methyl Siloxane And 50% Phenyl Methyl Siloxane,It Was Possible To Separate 201 Pcb Congeners With Only Four Unresolved Pairs. The Data Compiled In This Study For All 209 Congeners Will Aid In The Identification Of Selected Individual Components Of These Environmental Pollutants. The Use Of This Data Also Presents The Opportunity For The Improved Quantification Of The Commercial Pcb Formulations.
DOI:10.1016/0045-6535(95)00140-4