CAS: 5504-24-5; 2-Phenylacetimidamide

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📜3-Amino-4-Phenylisoxazol-5-One置于palladium On Activated Charcoal 氢气体系中,用 乙醇 作为反应溶剂,化学反应 3.0H,反应生成 苯乙脒
参考文献:Synthesis And Rearrangement Of 2-Oxo-3-Phenylisoxazolo[2,3-A]Pyrimidines
标题:Synthesis And Rearrangement Of 2-Oxo-3-Phenylisoxazolo[2,3-A]Pyrimidines
摘要:2-Oxo-3-Phenylisoxazolo[2,3-Alpha]Pyrimidine Derivatives Were Synthesized By The Reaction Of 3-Amino-4-Phenyl-5-Isoxazolone With Malonaldehyde Tetraacetal,3-Oxobutyraldehyde Diacetal,2,4-Pentanedione,And 1-Phenyl-1,3-Butanedione. The Regioselectivity Of This Reaction Was Determined By X-Ray Single Crystal Structural Analysis. Upon Heating Either In Water Or In Ethanol This Bicyclic System Underwent A Ring Opening,Followed By Decarboxylation To Yield Phenylpyrimidylmethanol And Phenylpyrimidyl Methyl Ethers. The Structures Of These 2-Oxoisoxazolo[2,3-Alpha]Pyrimidines And The Mechanism Of Their Rearrangement Is Discussed.
DOI:10.1021/jo00121A049

专利信息

专利号:US-6683189-B1
优先权日:1996-02-26
标 题 :Method for the synthesis of pyrrole and imidazole carboxamides on a solid support
发明人：DERVAN PETER B; BAIRD ELDON
权利人:CALIFORNIA INST OF TECHN
摘要:The present invention describes a novel method for the solid phase synthesis of polyamides containing imidazole and pyrrole carboxamides. The polyamides are prepared on a solid support from aromatic carboxylic acids and aromatic amines with high stepwise coupling yields (>99%), providing milligram quantities of highly pure polyamides. The present invention also describes the synthesis of analogs of the natural products Netropsin and Distamycin A, two antiviral antibiotics. The present invention also describes a novel method for the solid phase synthesis of imidazole and pyrrole carboxamide polyamide-oligonucleotide conjugates. This methodology will greatly increase both the complexity and quantity of minor-groove binding polyamides and minor-groove binding polyamide-oligonucleotide conjugates which can be synthesized and tested.

专利号:US-9353057-B2
优先权日:2003-12-30
标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
发明人：GALLOP MARK A; DAI XUEDONG; SCHEUERMAN RANDALL A; RAILLARD STEPHEN P; MANTHATI SURESH K; YAO FENMEI; PHAN THU; LUDWIKOW MARIA; PENG GE; BHAT SEEMA
权利人:XENOPORT INC
摘要:Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

专利号:WO-9312076-A1
优先权日:1991-12-13
标题:Reagents for automated synthesis of peptide analogs
发明人：WEBB THOMAS ROY
权利人:CORVAS INT INC
摘要:Reagents suitable for synthesis of peptide analogs using automated peptide synthesis and procedures for synthesis of peptide analogs are provided.

专利号:EP-0842924-B1
优先权日:1996-11-14
标 题 :Pyridine intermediates, useful in the synthesis of beta-adrenergic receptor agonists
发明人：WRIGHT STEPHEN WAYNE
权利人:PFIZER
摘要:The present invention relates to certain compounds of the formula (I), which are useful in the synthesis of certain beta -adrenergic receptor agonists. The invention also relates to a process for synthesizing the compounds of formula (I) and to compounds of the formula (II), wherein R<1>, R<2> and R<4> are defined herein, which are useful in the synthesis of the compounds of formula (I). The invention also relates to a process for synthesizing a compound of formula (II). The invention further relates to processes for synthesizing compounds of formula (Z*), R<1>, R<2> and Y<2*> are defined herein.o

专利号:US-5367072-A
优先权日:1990-12-14
标 题 :Reagents for automated synthesis of peptide analogs
发明人：WEBB THOMAS R
权利人:CORVAS INT INC
摘要:Reagents suitable for synthesis of peptide analogs using automated peptide synthesis and procedures for synthesis of peptide analogs are provided.

专利号:US-5849955-A
优先权日:1996-12-05
标题 :Process for the synthesis of 2-hydroxy-4-alkyloxy benzophenone
发明人：NOTARI MARCELLO; MIZIA FRANCO; RIVETTI FRANCO
权利人:ENICHEM SPA
摘要:A process is described for the synthesis of 2-hydroxy-4-alkyloxy benzophenone by the selective alkylation of 2,4-dihydroxy benzophenone with a dialkyl carbonate, in liquid phase, in the presence of suitable catalysts, at a temperature ranging between 120 DEG and 220 DEG C. and at a total pressure ranging from 2 to 60 ate.