CAS: 39856-58-1; 2-Bromopyridin-3-Amine

相似化合物

116026-98-3 19755-53-4 39856-57-0

上下游产品

CAS号19755-53-4 2-溴-3-硝基吡啶 | CAS号87674-18-8 2-溴烟碱 | CAS号462-08-8 3-氨基吡啶 | CAS号4214-75-9 2-氨基-3-硝基吡啶 | CAS号6332-56-5 2-羟基-3-硝基吡啶 | CAS号42242-11-5 3-氨基-2-吡啶甲腈 | CAS号452972-08-6 2-溴吡啶-3-硼酸 | CAS号50608-99-6 3-氨基吡啶-2-甲酰胺 | CAS号40273-45-8 2-溴-3-氟吡啶 | CAS号452972-12-2 2-溴-3-(4,4,5,5-... | CAS号835882-02-5 N-(2-溴吡啶-3-基)三甲基乙酰胺 | CAS号272-49-1 4-氮杂吲哚 | CAS号7689-62-5 2-氯-1,5-萘啶 | CAS号6298-19-7 2-氯-3-氨基吡啶 | CAS号57135-09-8 吡啶并[3,2-D][1,3]...

2-溴-3-硝基吡啶置于双联邻苯二酚硼酸酯,水体系中,用 四氢呋喃 用作溶剂,以90 %的收率获得2-溴-3-氨基吡啶
参考文献:通过硝基芳烃还原和亚胺水加氢一锅法构建四氢喹喔啉的无金属级联反应
标题:通过硝基芳烃还原和亚胺水加氢一锅法构建四氢喹喔啉的无金属级联反应
摘要:开发了一种无金属一锅级联工艺,包括还原硝基芳烃,环化以及用 B 2 Cat 2和水对亚胺进行连续氢化,以直接从容易获得的 2-硝基苯胺或邻二硝基苯与 α-酮酯构建二氢喹喔啉酮和四氢喹喔啉和α-二酮.该策略以非常好至优异的收率和对许多官能团的耐受性提供了各种二氢喹喔啉酮和四氢喹喔啉.通过控制实验和密度泛函理论(dft)计算进行的机理研究表明,该级联过程涉及硝基芳烃的脱氧还原,美拉德反应和氢化生成二氢喹喔啉酮和四氢喹喔啉.该方法旨在减少对环境的影响,同时保持硝基芳烃还原和二氢喹喔啉酮和四氢喹喔啉合成的高产率和选择性.
Doi:10.1039/d3Nj05093A

专利信息

专利号:US-2025188046-A1
优先权日:2023-12-08
标题:Ultrafast flow synthesis of functionalized sulfonyl fluorides and subsequent sufex connections via lithiated chemistry
发明人：KIM DONG-PYO; KANG JI-HO
权利人:POSTECH RES & BUSINESS DEV FOUND
摘要:Disclosed are ultrafast flow synthesis of functionalized sulfonyl fluorides and subsequent SuFEx connections via lithiated chemistry. In detail, a method of synthesizing an ortho-functionalized benzenesulfonyl fluoride derivative, the method comprises (a) reacting a benzenesulfonyl fluoride derivative represented by structural formula 1 with an organolithium represented by structural formula 2, thus synthesizing an intermediate represented by structural formula 3 in reaction scheme 1 and (b) reacting the intermediate with an electrophile, thus synthesizing a compound represented by structural formula 4 or a compound represented by structural formula 4′. The present disclosure enables the synthesis of several functionalized sulfonyl fluorides within a few seconds under mild temperature conditions in addition to the chemistry of Sulfonyl Fluoride Exchange (SuFEx), which is a next-generation click chemistry, so that sulfonyl fluoride, the main reactant of the SuFEx reaction, can be efficiently secured.

专利号:WO-0005212-A1
优先权日:1998-07-21
标 题:3-substituted pyridine compounds and related synthesis
发明人：HOGLEN DEAN KENT
权利人:NOVARTIS AG; NOVARTIS ERFIND VERWALT GMBH; HOGLEN DEAN KENT
摘要:The present invention relates to 3-substituted and 2,3-disubstituted pyridine compounds of formula (I), wherein R1 is C1-C4 haloalkyl and R4 is H, halogen or C1-C4 alkylthio; and acid addition salts thereof which are useful as intermediates in the synthesis of pyridylsulfonylurea herbicides. The invention also relates to arylation of alcohols using a pyridinediazonium salt. More particularly the arylation process of the instant invention relates to the synthesis of 2,3-disubstituted pyridine compounds via anhydrous diazotization of 3-aminopyridines to form a diazonium salt intermediate that is then reacted with the appropriate alcohol to produce the desired product. The invention additionally relates to pyridine-3-diazonium salt intermediates.

专利号:US-2022356182-A1
优先权日:2009-03-27
标题 :Inhibitors of hepatitis c virus replication
发明人：COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOLL RICHARD; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-11053243-B2
优先权日:2009-03-27
标 题:Inhibitors of hepatitis C virus replication
发明人：COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOIL RICHARD; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-9090661-B2
优先权日:2009-03-27
标 题:Inhibitors of hepatitis C virus replication
发明人：COBURN CRAIG A; MCCAULEY JOHN A; LUDMERER STEVEN W; LIU KUN; VACCA JOSEPH P; WU HAO; HU BIN; SOLL RICHARD; SUN FEI; WANG XINGHAI; YAN MAN; ZHANG CHENGREN; ZHENG MINGWEI; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-6710180-B2
优先权日:1998-07-21
标题 :Diazonium salts which are intermediates for 3-substituted pyridines
发明人：HOGLEN DEAN KENT
权利人:SYNGENTA PARTICIPATIONS AG
摘要:The present invention relates to 3-substituted and 2,3-disubstituted pyridine compounds which are useful as intermediates in the synthesis of pyridylsulfonylurea herbicides. The invention also relates to arylation of alcohols using a pyridinediazonium salt. More particularly the arylation process of the instant invention relates to the synthesis of 2,3-disubstituted pyridine compounds via anhydrous diazotization of 3-amninopyridines to form a diazonium salt intermediate that is then reacted with the appropriate alcohol to produce the desired product. The invention additionally relates to pyridine-3-diazonium salt intermediates.