CAS: 2211-94-1; 2-((4-Methoxyphenoxy)Methyl)Oxirane

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CAS号150-76-5 4-甲氧基苯酚(MEHQ) | CAS号106-89-8 环氧氯丙烷 | CAS号13391-35-0 1-(烯丙氧基)-4-甲氧基苯 | CAS号3132-64-7 环氧溴丙烷 | CAS号42900-54-9 1-(4-甲氧苯氧基)-2-丙醇 | CAS号213828-28-5 1-(4-methoxyphe... | CAS号1877-75-4 对甲氧基苯氧乙酸 | CAS号150-76-5 4-甲氧基苯酚(MEHQ) | CAS号39144-44-0 1-methoxy-3-(4-... | CAS号122-60-1 环氧丙基苯基醚 | CAS号108-95-2 苯酚 | CAS号13391-35-0 1-(烯丙氧基)-4-甲氧基苯 | CAS号156737-65-4 (2R)-1-hexadeco...

📜4-甲氧基苯酚置于双氧水,Potassium Carbonate体系中,用 甲醇,水,N,N-二甲基甲酰胺,乙腈 用作溶剂,化学反应 106.0H,反应生成2,3-环氧丙基-4-甲氧基苯基醚
参考文献:Mfi型钛硅酸盐上过氧化氢对烯丙氧基苯的化学选择性环氧化
标题:Mfi型钛硅酸盐上过氧化氢对烯丙氧基苯的化学选择性环氧化
摘要:用钛取代的silicalite-1(ts-1)作为催化剂开发了烯丙氧基苯的ah 2 O 2化学选择性环氧化.使用5.30 G的烯丙氧基苯进行克级的2-(苯氧基甲基)环氧乙烷的合成,以93%的分离产率产生5.21 G的2-(苯氧基甲基)环氧乙烷.Meoh / Mecn作为混合溶剂即使在40oc时也能促进所需的环氧化.研发的ts-1催化剂可重复使用,生产高效且具有广泛的底物范围.
Doi:10.1002/ejoc.202000249

专利信息

专利号:US-7038062-B2
优先权日:2004-07-01
标题:Synthesis of cyclic trithiocarbonates from epoxides
发明人：PARKER DANE KENTON
权利人:GOODYEAR TIRE & RUBBER
摘要:This invention provides a low cost technique for synthesizing cyclic trithiocarbonates by a simple one step process from epoxides that can be conducted under atmospheric pressure. This synthesis can be depicted as follows: n nwherein R represents a moiety selected from the group consisting of alkyl groups and aryl groups, wherein R′ represents a moiety selected from the group consisting of alkyl groups, aryl groups, and hydrogen atoms, and wherein R″ represents a moiety selected from the group consisting of alkyl groups, aryl groups, and hydrogen atoms, wherein the R moiety and the R′ moiety can be bonded together to form a cyclic structure, with the proviso that R″ represents a hydrogen atom if R′ represents an alkyl group or an aryl group. In this process carbon disulfide and a thiocyanate salt, such as potassium thiocyanate, are reacted with the epoxide in an ionic liquid, such as 1-butyl-3-methylimidazolium hexafluorophosphate ([Bmim] PF 6 ) in the presence of water to produce the cyclic trithiocarbonate.

专利号:US-10647672-B2
优先权日:2017-10-03
标 题:Modulators of cell adhesion, methods and compositions therefor
发明人：BLASCHUK OREST WILLIAM
权利人:Zonula Incorporated; ZONULA INC
摘要:Compounds with activity as modulators of cell adhesion are disclosed. The compounds are derivatives of piperidin-4-amine. In some embodiments, a compound can be linked to a targeting agent, a pharmaceutically active substance and/or a support material. Methods for enhancing or inhibiting classical cadherin-mediated functions are also disclosed. The compounds can be used for the treatment or prevention of a variety of diseases including cancer. Compositions and devices, including skin patches comprising a compound are also disclosed. In addition, methods of synthesis of the compounds are provided.

专利号:US-9150840-B2
优先权日:2011-08-26
标题 :Isolated bacterial strain of Achromobacter sp. MTCC 5605 and a highly enantioselective epoxide hydrolase isolated therefrom
发明人：KAMAL AHMED; KHANNA ROHINI; KUMAR CHITYAL GANESH; SHAIK ANVER BASHA; KUMAR MATAM SHIVA
权利人:KAMAL AHMED; KHANNA ROHINI; KUMAR CHITYAL GANESH; SHAIK ANVER BASHA; KUMAR MATAM SHIVA; COUNCIL SCIENT IND RES
摘要:The present invention relates to a novel epoxide hydrolase enzyme which aims to achieve a high degree of resolution towards a broader range of substrates with high enantioselectivity and yields with minimal product inhibition. The invention further relates to a new bacterial strain Achromobacter sp. MTCC 5605 isolated from a petroleum-contaminated sludge sample, capable of producing the said enzyme. It is notable that the enzyme can be used as whole bacterial cell preparation, which allows continuous hydrolysis of substrates at even higher concentration and have an advantage of being recycled. The invention further relates to a process for the hydrolysis of different aryl epoxides which are potential synthons of intermediates for the synthesis of chiral amino alcohols and bioactive compounds like β-blockers.

专利号:US-2002187983-A1
优先权日:2001-05-17
标 题:Process for the synthesis of derivatives of 2, 3-dihydro-1, 4-dioxino- [2, 3-f] quinoline

专利号:US-2004186123-A1
优先权日:2001-05-17
标题 :Process for the synthesis of derivatives of 2, 3-dihydro-1, 4-dioxino- [2, 3-f] quinoline

专利号:US-3953604-A
优先权日:1972-01-14
标 题:1-(2-Substituted-chromonyloxy)-2-hydroxy-3-(substituted phenoxy)propanes
发明人：WARREN BRIAN THOMAS; SPICER JOHN WILLIAM
权利人:MILES LAB
摘要:Definitions: in the following Formulae I, II and IV, R 1 represents hydrogen, alkyl of 1 to 4 carbon atoms, or a nontoxic cation, while each of R 2 , R 3 , R 4 , R 5 , and R 6 symbolizes hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, carboxy, carbalkoxy of 1 to 4 carbon atoms, trihalomethyl, halogen, nitro or cyano. n Certain 1-(2-substituted-chromon-yloxy)-2-hydroxy-3-(substituted-phenoxy)propanes (Formula I), ##SPC1## n can be synthesized from intermediate bis-(substituted-phenoxy)propanes (Formula II), ##SPC2## n by condensation with diethyl oxalate in the presence of sodium ethoxide followed by cyclization with a mixture of glacial acetic acid and concentrated sulfuric or a mixture of concentrated hydrochloric acid and a lower alcohol containing up to 4 carbon atoms. n The bis-(substituted-phenoxy)propane intermediates (Formula II) are prepared by reacting a dihydroxyacetophenone (Formula III), ##SPC3## n with a (substituted-phenyl)glycidyl ether (Formula IV), ##SPC4## n in an organic solvent in the presence of a catalyst. n The 1-(2-substituted-chromon-yloxy)-2-hydroxy-3-(substituted-phenoxy)propanes (Formula I) are useful in the treatment of allergic conditions in mammals. The bis-(substituted-phenoxy)propanes (Formula II) are useful as intermediates in the synthesis of the latter compounds. Methods of preparing compounds having Formulae I and II are described. Methods of treating allergic conditions in mammals utilizing compounds of Formula I are also disclosed.