CAS: 2086-62-6; 2-(2-Bromoethyl)Naphthalene

相似化合物

13686-49-2 939-27-5 41332-02-9

上下游产品

naphthalen-2-ethanol 2-naphthylacetic acid methyl 2-naphthylacetate 2-naphthalenylmagnesium bromide 2-(2-[2]naphthyl-ethyl)-cyclohexanone naphthalen-2-ethanol 2-naphthylethylene 1-[2-(2-naphthyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine

📜2-甲基萘置于盐酸,N-溴代丁二酰亚胺(Nbs),Lithium Aluminium Tetrahydride,氢溴酸,Sodium Carbonate,过氧化苯甲酰体系中,用 四氯化碳,乙醚,乙醇,水 用作溶剂,化学反应 24.0H,反应生成2-(2-溴-乙基)-萘
参考文献:N-酰氧基-N-烷氧基酰胺的 致突变性,作为dna嵌入的指示剂第1部分:萘作为dna嵌入剂的证据†
标题:N-酰氧基-N-烷氧基酰胺的 致突变性,作为dna嵌入的指示剂第1部分:萘作为dna嵌入剂的证据†
摘要:N-酰氧基-N-烷氧基酰胺是鼠伤寒沙门氏菌ta100中的直接作用诱变剂,对log P具有线性依赖性,在log P 0 = 6.4时最大.已证明在三个侧链的任何一个上带有萘基且log P 0 <6.4的八种n-酰氧基-N-烷氧基酰胺(2-9) 对鼠伤寒沙门氏菌ta100的致突变性均比50个诱变剂均匀得多.没有萘.2-9的活动增强可能是由于萘与细菌dna的插入结合,因为ta98是鼠伤寒沙门氏菌的移码菌株,也被插入剂修饰,在ta98中也有许多活性.带有萘的诱变剂的dna损伤特征证实了掺入萘后与dna的反应性增强,并且与不含萘的诱变剂相比具有不同的结合方式.该效果与萘是否连接至供电子的烷基或吸电子的酰基,烷基系链长度或(在6和7的情况下)萘的连接点无关.已为所有58个同类物构建了新的定量结构活性关系,其中包括对数 P和指标变量,I,对于萘的存在(i = 1)或不存在(i = 0),从中可以量化出萘的活性增强作用在三个和四个log
Doi:10.1039/c6Ob00162A

专利信息

专利号:US-4528195-A
优先权日:1978-02-01
标题:Imidazole derivatives and salts thereof, their synthesis and intermediates and pharmaceutical formulations
发明人：THOROGOOD PETER B
权利人:THOROGOOD PETER B
摘要:Pharmaceutical formulations comprising an imidazole (or pharmaceutically acceptable salt thereof) of formula: ##STR1## wherein (i) A is an aliphatic hydrocarbon residue of from 1 to 4 carbon atoms and R is a naphthyl, tetrahydronaphthyl, heterocyclyl, arylthio, arylalkylthio, aryloxy, arylalkyloxy, arylhydroxymethylene, arylcarbonyl, arylalkylcarbonyl, alkyloxy, alkylthio or a substituted cycloalkyl or cycloalkenyl group or n (ii) A is an --SO 2 -- group and R is aryl or heterocyclyl or n (iii) A is a chemical bond and R is a heterocyclyl or n Some of these imidazoles and salts are novel. n Methods of preparing the imidazoles are disclosed. The imidazoles and their salts are useful in the treatment or prophylaxis of thrombo-embolic conditions, shock and angina pectoris.