CAS: 18699-02-0; 2-(4-Acetamidophenyl)Acetic Acid

该化合物是一个主要因其用于治疗风湿性关节炎和其他炎症而得到承认的化学化合物,属于非类类类非类类抗炎药物,具有免疫性肺炎特性;Actarit功能,抑制某些酶在炎症过程中的活动,从而减少疼痛和肿胀;该化合物的特点是水溶性相对较低,可影响其生物利用率和体内吸收率;此外,该化合物可能具有一系列副作用,包括胃肠紊乱和潜在的肝脏毒性,在治疗期间需要仔细监测;其致癌基因在肝脏中含有代谢性,主要通过尿液排出;

结构式图片

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ECHA物质C&L通报REACH预注册

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CAS号1197-55-3 对氨基苯乙酸 | CAS号108-24-7 乙酸酐 | CAS号64-19-7 冰醋酸 | CAS号113180-61-3 4'-(4''-carboxy... | CAS号556-18-3 4-氨基苯甲醛 | CAS号106664-49-7 (4-acetamidophe... | CAS号106664-49-7 (4-acetamidophe... | CAS号23784-25-0 N-[4-[2-(4-hydr... | CAS号2952-00-3 2-(反式-4-氨基环己基)乙酸 | CAS号2901-44-2 反式-4-乙酰氨基环己烷乙酸 | CAS号2901-45-3 2-(4-acetamid°C... | CAS号104126-70-7 2-(4-氨基-3-硝基苯基)乙酸乙酯 | CAS号16375-88-5 4-乙酰胺苄醇 | CAS号122-85-0 对乙酰氨基苯甲醛 | CAS号103-84-4 N-乙酰苯胺 | CAS号13475-17-7 4-乙酰氨基苯乙酸乙酯

合成工艺路线路线简述

    4-(2-硝基乙烯基)苯胺置于钾硼氢,溶剂黄146,Sodium Nitrite体系中,用 乙醇,二甲基亚砜,N,N-二甲基甲酰胺 用作溶剂,化学反应 3.0H,反应生成阿克他利
    参考文献:Zhou,Li-Yi; Yang,Jun; Yan,Xi-Qing,Asian Journal Of Chemistry,2012,Vol. 24,# 4,P. 1538-1540
    标题:Zhou,Li-Yi; Yang,Jun; Yan,Xi-Qing,Asian Journal Of Chemistry,2012,Vol. 24,# 4,P. 1538-1540

    海关参考信息

    专利信息


    专利号:US-9051302-B2
    优先权日:2008-01-15
    标 题 :Synthesis of resorcylic acid lactones useful as therapeutic agents
    发明人:WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN
    权利人:WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN; UNIV STRASBOURG
    摘要:Disclosed are macrocyclic compounds of formulae I, I′, II, II′, III, III′, IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90.

    专利号:WO-2024054881-A1
    优先权日:2022-09-07
    标题:Ligand-enabled scalable c-h hydroxylation of benzoic and phenylacetic acids at room temperature
    发明人:YU JIN-QUAN; LI ZHEN; PARK HAN
    权利人:SCRIPPS RESEARCH INST
    摘要:The application discloses industry scalable methods of using bifunctional bidentate pyridone-carboxylic acid ligands, such as 2-methyl-2-(6-oxo-1,6-dihydropyridin-2-yl)propanoic acid, that enable room-temperature Pd-catalyzed C-H hydroxylation of a broad range of benzoic and phenylacetic acids with an industry-compatible oxidant, aqueous hydrogen peroxide, at room temperature. Further disclosed are methods of derivatization of the resulting hydroxylation products, synthesis of polyfluorinated natural products coumestan or pterocarpene from phenol building blocks, and hydroxylation of ibuprofen using this methodology,

    专利号:US-5672489-A
    优先权日:1993-09-08
    标题 :Catalytic antibodies hydrolyzing acylated carbohydrates in a regioselective and stereoselective manner
    发明人:FUJII IKUO; IWABUCHI YOSHIHARU; MIYASHITA HIDEAKI
    权利人:PROTEIN ENGINEERING RESEARCH I
    摘要:A method of regio-and stereoselective hydrolysis to deprotect an acylated hydroxy group in acylated carbohydrates, which contributes to synthesis of complex oligosaccharides, is provided. The method utilizes catalytic antibodies as hydrolase.

    专利号:US-10239856-B2
    优先权日:2008-01-15
    标题:Synthesis of resorcylic acid lactones useful as therapeutic agents

    专利号:CN-101990399-B
    优先权日:2008-01-15
    标 题:Synthesis of dihydroxybenzoic acid lactones as therapeutic agents

    专利号:US-2011217335-A1
    优先权日:2008-01-15
    标 题 :Synthesis of resorcylic acid lactones useful as therapeutic agents
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    主要参考文献


    1: Takeba Y, Suzuki N, Wakisaka S, Nagafuchi H, Mihara S, Kaneko A, Asai T, Sakane T. Effects of actarit on synovial cell functions in patients with rheumatoid arthritis. J Rheumatol. 1999 Jan;26(1):25-33. doi: 10.4103/0250-474X.84581.
    4: Canudas N, Figueroa L, Zamora D, Villamizar JE, Guedez A, Fuentes JM, Castelli C, Taddei A. Photosensitizing properties of Actarit, an antirheumatic drug. Arzneimittelforschung. 2008;58(4):182-7. doi: 10.1055/s-0031-1296490. Japanese. Epub 2007 Oct 22. doi: 10.1002/jms.3730. doi: 10.1016/j.jpha.2014.01.002. Epub 2014 Jan 25.
    11: Nakamura H, Ueki Y, Sakito S, Matsumoto K, Yano M, Miyake S, Tominaga Y, Eguchi K. Clinical effects of actarit in rheumatoid arthritis: improvement of early disease activity mediated by reduction of serum concentrations of nitric oxide. Clin Exp Rheumatol. 2000 Jul-Aug;18(4):445-50. doi: 10.3109/s101650050007. doi: 10.3109/s101650200021. Review. Japanese. Japanese. doi: 10.3109/s10165-004-0345-y. doi: 10.1002/jps.21725. Japanese. Japanese.

    合成参考文献


    摘要:Obexer, R.; Garrabou, X.; Hilvert, D., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 3, 591.
    参考文献:10.1007/s10165-011-0466-z|10.3109/s10165-011-0466-z
    摘要:Wakabayashi K, Otsuka K, Sato M, Takahashi R, Odai T, Isozaki T, Yajima N, Miwa Y, Kasama T. Elevated serum levels of macrophage migration inhibitory factor and their significant correlation with rheumatoid vasculitis disease activity. Mod Rheumatol. 2012 Feb;22(1):59–65. doi: 10.1007/s10165-011-0466-z.
    参考文献:10.1055/s-0031-1296490
    摘要:Canudas N, Figueroa L, Zamora D, Villamizar JE, Guedez A, Fuentes JM, Castelli C, Taddei A. Photosensitizing properties of Actarit, an antirheumatic drug. Arzneimittelforschung. 2008;58(4):182–7. doi: 10.1055/s-0031-1296490.
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