专利号:US-9051302-B2 优先权日:2008-01-15 标 题 :Synthesis of resorcylic acid lactones useful as therapeutic agents 发明人:WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN 权利人:WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN; UNIV STRASBOURG 摘要:Disclosed are macrocyclic compounds of formulae I, I′, II, II′, III, III′, IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90.
专利号:WO-2024054881-A1 优先权日:2022-09-07 标题:Ligand-enabled scalable c-h hydroxylation of benzoic and phenylacetic acids at room temperature 发明人:YU JIN-QUAN; LI ZHEN; PARK HAN 权利人:SCRIPPS RESEARCH INST 摘要:The application discloses industry scalable methods of using bifunctional bidentate pyridone-carboxylic acid ligands, such as 2-methyl-2-(6-oxo-1,6-dihydropyridin-2-yl)propanoic acid, that enable room-temperature Pd-catalyzed C-H hydroxylation of a broad range of benzoic and phenylacetic acids with an industry-compatible oxidant, aqueous hydrogen peroxide, at room temperature. Further disclosed are methods of derivatization of the resulting hydroxylation products, synthesis of polyfluorinated natural products coumestan or pterocarpene from phenol building blocks, and hydroxylation of ibuprofen using this methodology,
专利号:US-5672489-A 优先权日:1993-09-08 标题 :Catalytic antibodies hydrolyzing acylated carbohydrates in a regioselective and stereoselective manner 发明人:FUJII IKUO; IWABUCHI YOSHIHARU; MIYASHITA HIDEAKI 权利人:PROTEIN ENGINEERING RESEARCH I 摘要:A method of regio-and stereoselective hydrolysis to deprotect an acylated hydroxy group in acylated carbohydrates, which contributes to synthesis of complex oligosaccharides, is provided. The method utilizes catalytic antibodies as hydrolase.
专利号:US-10239856-B2 优先权日:2008-01-15 标题:Synthesis of resorcylic acid lactones useful as therapeutic agents
专利号:CN-101990399-B 优先权日:2008-01-15 标 题:Synthesis of dihydroxybenzoic acid lactones as therapeutic agents
专利号:US-2011217335-A1 优先权日:2008-01-15 标 题 :Synthesis of resorcylic acid lactones useful as therapeutic agents
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合成参考文献
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