CAS: 179897-94-0; 5-Fluoro-2-Methoxyphenylboronic Acid

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CAS号121-43-7 硼酸三甲酯 | CAS号452-08-4 2-溴-4-氟苯甲醚 | CAS号459-60-9 4-氟苯甲醚 | CAS号1123158-89-3 3-bromo-5-(5-fl... | CAS号72955-97-6 5-氟-2-甲氧基苯酚 | CAS号259209-20-6 5-氟-2-羟基苯基硼酸 | CAS号1178011-38-5 2-(5-fluoro-2-m... | CAS号779331-49-6 4-氟-2-(4,4,5,5-... | CAS号877383-80-7 2-fluoro-4-(5-f...

对氟苯甲醚置于正丁基锂,硼酸三异丙酯体系中,用 四氢呋喃,环己烷 用作溶剂,化学反应 5.0H,以30%的收率获得5-氟-2-甲氧基苯硼酸
参考文献:作为多巴胺d4受体配体的新系列吗啉和1,4-恶唑烷衍生物:合成和3D-Qsar模型.
标题:作为多巴胺d4受体配体的新系列吗啉和1,4-恶唑烷衍生物:合成和3D-Qsar模型.
摘要:自多巴胺d(4)受体亚型的鉴定和关于其可能参与精神分裂症的推测以来,选择性d(4)配体的开发已投入大量工作.这些选择性配体可能是没有锥体束外副作用的有效抗精神病药.这项工作描述了对多巴胺d(4)受体具有选择性的新系列的2,4-二取代的吗啉和2,4-二取代的1,4-恶唑酮的合成.进行了使用grid / Golpe方法的3D-Qsar分析,目的是更好地了解化学结构与生物活性之间的关系.通过查看系数图,我们可以确定对于亲和力至关重要的区域位于两个苯环系统(对氯苄基)周围,和属于吗啉或1,4-氧杂庚烷体系的脂族胺.另外,吗啉或1,4-氧杂庚烷环的大小对于亲和力似乎很重要.
Doi:10.1021/jm031111M

专利信息

专利号:US-2009076268-A1
优先权日:2007-09-14
标 题:Facile assembly of fused benzofuro-heterocycles
发明人：FITZGERALD ANNE E; LIU JING; MANI NEELAKANDHA S
权利人:FITZGERALD ANNE E; LIU JING; MANI NEELAKANDHA S
摘要:This invention concerns the synthesis of polycyclic structural components of pharmacological compounds, including the synthesis of fused benzofuro-heterocycles, through selective palladium-catalyzed cross-coupling and intramolecular cyclization.

专利号:US-2006111438-A1
优先权日:2004-10-21
标 题:Asymmetric synthesis of substituted dihydrobenzofurans
发明人：GONTCHAROV ALEXANDER V; KHAFIZOVA GULNAZ; POTOSKI JOHN R; YU QING; SHAW CHIA-CHENG; STACK GARY P; ZHOU DAHUI
权利人:WYETH CORP
摘要:The present invention concerns production of a compound of the formula n n nor a pharmaceutically acceptable salt thereof by a process which utilizes the cyclization of a compound of the formula: n n nwhere Ar, Y, R 1 , R y , R 2 , and m are as defined herein.

专利号:AU-2005299884-A1
优先权日:2004-10-21
标 题 :Asymmetric synthesis of substituted dihydrobenzofurans

专利号:EP-1802597-A1
优先权日:2004-10-21
标题:Asymmetric synthesis of substituted dihydrobenzofurans

专利号:WO-2006047228-A1
优先权日:2004-10-21
标题 :Asymmetric synthesis of substituted dihydrobenzofurans

专利号:US-2025026766-A1
优先权日:2022-01-12
标题 :Thiazolopyridyl Amide Derivatives as DNA Polymerase Theta Inhibitors
发明人：LI JING; XU WENQING; WANG ZHIWEI
权利人:BEIGENE LTD
摘要:The present invention relates to compounds containing thiazolopyridyl amide structure, the process for their synthesis, as well as the use of such compounds for inhibiting DNA Polymerase Theta (Pol Theta), and in the treatment of various diseases including cancers.