CAS: 166328-16-1; 2-Fluoro-5-Methylbenzeneboronic Acid

相似化合物

1192045-84-3 762287-58-1 1586045-40-0

上下游产品

p-fluorotoluene 5-(2-fluoro-5-methylphenyl)furan-2-carboxylic acid methyl ester 2-(1-di-tert-Butoxycarbonylaminoisoquinolin-6-ylamino)-2-(2-fluoro-5-methylphenyl)acetic acid 5-fluoro-2-methyl-2'-[(4-methylphenyl)ethynyl]biphenyl 2'-fluoro-5'-methylbiphenyl-2-carbonitrile

对氟甲苯置于仲丁基锂,硼酸三甲酯体系中,用 四氢呋喃,环己烷 用作溶剂,化学反应 0.19H,以96%的收率获得2-氟-5-甲基苯硼酸
参考文献:Crystallization-Induced Asymmetric Transformation Vs Quasi-Racemate Formation In Tetravalent Boron Complexes
标题:Crystallization-Induced Asymmetric Transformation Vs Quasi-Racemate Formation In Tetravalent Boron Complexes
摘要:Crystallization-Induced Asymmetric Transformation (At) Has Been Achieved With The Salicaldimine Complexes 8/9,11/12,And 14A/15A And With The Oxazaborolidinone Complexes 22B/23B And 22C/23C. In The Case Of 22A And 23A,The Initially Formed 3.1 Mixture Of Diastereomers Crystallizes Under Equilibrium Conditions To Afford A Quasi-Racemate 24,Containing Both Diastereomers In The Unit Cell. Enolate Formation From Ent-22B Is Demonstrated,And Methylation occurs To Give 26A. Aldol Condensation Of The Enolate Is Also Feasible,And Hindered Aldehydes Afford Adducts Such As 27A Or 27B With Good Diastereoselectivity. Factors That Contribute To Quasi-Racemate Formation Are Discussed.
Doi:10.1021/ja994023T

专利信息

专利号:US-9040704-B2
优先权日:2011-08-12
标题:Fluorescent dyes with large stokes shifts
发明人：PIERS WARREN EDWARD; ARANEDA JUAN FELIPE
权利人:PIERS WARREN EDWARD; ARANEDA JUAN FELIPE; UTI LIMITED PARTNERSHIP
摘要:Herein are disclosed fluorescent dyes based around a framework for a ligand comprising a pyridyl group linked to a diaryl anilido unit. A variety of ligands based on this framework are disclosed. The ligands chelate to a BF 2 center to produce the fluorescent dye. The disclosed dyes combine longer Stokes shifts (approximately 100 nm) with increased quantum yields. They are also photostable in aqueous and organic solutions for several hours. These dyes may be used in the labeling of biomolecules for bioimaging and assays. Also disclosed are methods for the synthesis of these dyes.

专利号:US-8933018-B2
优先权日:2011-02-07
标题 :Boron containing polybasic bacterial efflux pump inhibitors and therapeutic uses thereof
发明人：GLINKA TOMASZ; HIGUCHI ROBERT; HECKER SCOTT; EASTMAN BRIAN; RODNY OLGA
权利人:GLINKA TOMASZ; HIGUCHI ROBERT; HECKER SCOTT; EASTMAN BRIAN; RODNY OLGA; REMPEX PHARMACEUTICALS INC
摘要:Disclosed herein are polybasic bacterial efflux pump inhibitors containing boronic acid functionality and their methods of synthesis, methods of use, and pharmaceutical compositions. Some embodiments include methods of treating or preventing a bacterial infection by co-administering to a subject infected with bacteria or at risk of infection with bacteria the efflux pump inhibitor with another anti-bacterial agent.

专利号:CN-111961073-A
优先权日:2020-09-08
标题 :Continuous synthesis method of arylboronic acid

专利号:CN-111961073-B
优先权日:2020-09-08
标题 :Continuous synthesis method of aryl boronic acid