CAS: 130888-29-8; [[diazonioimino-Bis(Diethylamino)-λ5-Phosphanyl]-Ethylamino]Ethane,Bromide

📜六乙基亚磷酸胺置于溴,Sodium Azide,18-冠醚-6体系中,用 乙醚 用作溶剂,化学反应 48.0H,以77%的收率获得叠氮化三(二乙胺基)溴化
参考文献:Epr和endor光谱研究芳族叠氮化物与三氯化镓的反应†
标题:Epr和endor光谱研究芳族叠氮化物与三氯化镓的反应†
摘要:的反应 三氯化镓 与苯基和氘代叠氮化物,以及 4-甲氧基苯基叠氮化物通过产物分析,连续波epr光谱和脉冲endor光谱检查了氘和氘的同位素异构体.产品包括相应的苯胺以及4-氨基二苯胺型二聚体和聚苯胺.二聚体[arnhc 6 H 4 Nh 2 ] + ˙和三聚体[arnhc 6 H 4 Nhc 6 H 4 Nh 2 ] +的自由基阳离子的复杂cw Epr光谱获得.借助氘取代类似物的数据以及脉冲davies Endor光谱对这些epr光谱进行了分析.自由基阳离子的dft计算提供了确凿的证据,并表明未成对的电子被容纳在广泛的π-离域轨道中.提出了一种机制来解释芳族叠氮化物还原转化为相应的苯胺并因此还原为二聚体和三聚体的机理.
Doi:10.1039/c0Ob00084A

专利信息

专利号:US-6552239-B1
优先权日:1999-10-28
标题:Synthesis of cyclopropaneacetylene by a one-pot process
发明人：BRANDS KAREL M J
权利人:MERCK & CO INC
摘要:The present invention relates to a process for the preparation of cyclopropaneacetylene by reacting a ketophosphonate with a diazo-transfer reagent in the presence of non-nucleophilic base in an aprotic solvent to generate a reaction mixture containing a ketodiazophosphonate compound and then reacting the reaction mixture with cyclopropanecarboxaldehyde in a non-nucleophilic base and a protic solvent to yield cyclopropaneacetylene.

专利号:US-12202782-B2
优先权日:2020-11-19
标 题:Processes and intermediates for preparing MCL1 inhibitors
发明人：DIXON DARRYL D; ISCHAY MICHAEL A; JOHNSON TREVOR C; MERIT JEFFREY E; REGENS CHRISTOPHER S; STANDLEY ERIC A; STEINHUEBEL DIETRICH P
权利人:GILEAD SCIENCES INC
摘要:The present disclosure relates to methods and intermediates for the synthesis of certain compounds that inhibit MCL1, for use in the treatment of cancers.