CAS: 1256584-75-4; Tert-Butyl 6-Cyano-2-(2-(4-Ethyl-3-Iodophenyl)Propan-2-yl)-1H-Indole-3-Carboxylate

丙二酸单叔丁酯置于sodium Dithionite,Caesium Carbonate,三乙胺,Magnesium Chloride体系中,用 四氢呋喃,乙二醇二甲醚,水,N,N-二甲基甲酰胺,异丙醇,甲苯 用作溶剂,化学反应 28.0H,反应生成叔-丁基6-氰基-2-(2-(4-乙基-3-碘苯基)丙-2-基)-1H-吲哚-3-羧酸酯
参考文献: Improved Process For The Preparation Of 9-Ethyl-6,6-Dimethyl-8-[4-(Morpholin-4-yl) Piperidin-1-Yl]-11-Oxo-6,11-Dihydro-5H-Benzo[b]Carbazole-3-Carbonitrile Hydrochloride[fr] Procédé Amélioré Pour La Préparation De Chlorhydrate De 9-éthyl-6,6-Diméthyl-8-[4-(Morpholin-4-yl) Pipéridin-1-Yl]-11-Oxo-6,11-Dihydro-5H-Benzo[b]Carbazole-3-Carbonitrile
标题: Improved Process For The Preparation Of 9-Ethyl-6,6-Dimethyl-8-[4-(Morpholin-4-yl) Piperidin-1-Yl]-11-Oxo-6,11-Dihydro-5H-Benzo[b]Carbazole-3-Carbonitrile Hydrochloride[fr] Procédé Amélioré Pour La Préparation De Chlorhydrate De 9-éthyl-6,6-Diméthyl-8-[4-(Morpholin-4-yl) Pipéridin-1-Yl]-11-Oxo-6,11-Dihydro-5H-Benzo[b]Carbazole-3-Carbonitrile
摘要:本发明涉及一种新型制备9-乙基-6,6-二甲基-8-[4-(吗啡啉-4-基)哌啶-1-基]-11-氧代-6,11-二氢-5H-苯并[b]咔唑-3-羧腈盐酸盐化合物的方法,该化合物的结构式如下所示:同时,本发明还提供了一种改进的制备叔丁基-4-(4-乙基-3-碘苯基)-4-甲基-3-氧代戊酸酯的方法,该化合物的结构式如下所示,该方法在阿雷替尼及其药用可接受盐的制备中有用.

专利信息

专利号:US-9573932-B2
优先权日:2015-03-02
标题:Synthesis of intermediates in the preparation of ALK inhibitor
发明人：XU YONG
权利人:XU YONG
摘要:The present disclosure provides a method for preparing a compound of formula XVII, comprising: (1) contacting a compound of formula XIV with a compound of formula 3 to obtain a compound of formula 2; and (2) contacting the compound of formula 2 with a compound of formula 4 to obtain a compound of formula XVII. The method is low toxicity, cheap, easy to get, environmentally and friendly, and is economical and industrially applicable.