专利号:US-2024294464-A1 优先权日:2021-10-27 标题 :Synthesis of restrained complexing agents 发明人:WONG NICHOLAS; GOSSELIN FRANCIS 权利人:GENENTECH INC 摘要:Improved methods of synthesis of a restrained complexing agent are described herein. Compounds, including salts and solvates thereof, and compositions relevant to the improved methods are also described.
专利号:US-8993762-B2 优先权日:2013-03-15 标题 :Total synthesis of thaxtomin A analogues and their intermediates 发明人:HUANG HUAZHANG; YAN DONG; XUE ZHIJIE; ZHANG HONGBO 权利人:MARRONE BIO INNOVATIONS INC; MARRONE BIO INNOVATIONS INC 摘要:Improved synthetic methods for the production of thaxtomin analogs, particularly thaxtomin A, and intermediates therefore such as substituted tryptophans and in particular, 4-nitro-L-tryptophan, and substituted phenyl acrylic acids are disclosed. Bioassays show that the synthetic thaxtomin A is not significantly different from the natural one in herbicidal activity.
专利号:US-2005027102-A1 优先权日:1992-12-28 标题 :Use of molecularly imprinted polymers for stereo- and/or regioselective synthesis 发明人:MOSBACH KLAUS; NICHOLLS IAN A; RAMSTROM OLOF 摘要:Molecularly imprinted polymers can be utilized in stereo- and regio-selective synthesis. These systems can be utilized, e.g. for peptide synthesis, by selectively coordinating reactants at a predetermined preformed cavity. Further, such polymers may be used for the selective removal of one enantiomeric species from solution, allowing reaction to be directed to another species in bulk solution leading to stereoselective and/or regio-selective synthesis in the cavity of for instance peptides. Additionally, when utilized as regioselectively interacting protectioning matrices, these polymers can direct reaction to an alternate centre of a reacting substrate.
专利号:EP-0675898-B1 优先权日:1992-12-28 标题 :Use of molecularly imprinted polymers for stereo- and/or regioselective synthesis 发明人:MOSBACH KLAUS; NICHOLLS IAN A; RAMSTROEM OLOF 权利人:MOSBACH KLAUS H 摘要:Molecularly imprinted polymers can be utilized in stereo- and regio-selective synthesis. These systems can be utilized, e.g. for peptide synthesis, by selectively coordinating reactants at a predetermined preformed cavity. Further, such polymers may be used for the selective removal of one enantiomeric species from solution, allowing reaction to be directed to another species in bulk solution leading to stereoselective and/or regioselective synthesis in the cavity of for instance peptides. Additionally, when utilized as regioselectively interacting protectioning matrices, these polymers can direct reaction to an alternate centre of a reacting substrate.
专利号:US-2447545-A 优先权日:1944-10-21 标 题 :Synthesis of tryptophane and intermediates therefor 发明人:SNYDER HAROLD R; SMITH CURTIS W 权利人:MERCK & CO INC
专利号:JP-2024539994-A 优先权日:2021-10-27 标 题:Synthesis of constrained complexing agents
[参考文献]: Griet Van Zeebroeck, Et Al. Transport And Signaling Via The Amino Acid Binding Site Of The Yeast Gap1 Amino Acid Transceptor. Nat Chem Biol. 2009 Jan;5(1):45-52. [参考文献]: H L Carthew, Et Al. Substance P-Induced Changes In Cell Genesis Following Diffuse Traumatic Brain Injury. Neuroscience. 2012 Jul 12:214:78-83. [参考文献]: Hassan Abdoul-Carime, Et Al. Degradation Of N-Acetyl Tryptophan By Low-Energy ( <12 Ev) Electrons. J Am Chem Soc. 2004 Sep 29;126(38):12158-61. [参考文献]: Helmut Grner, Et Al. Electron Transfer From Aromatic Amino Acids To Triplet Quinones. J Photochem Photobiol B. 2007 Sep 25;88(2-3):83-9. [参考文献]: K M Meisenheimer, Et Al. Nucleoprotein Photo-Cross-Linking Using Halopyrimidine-Substituted Rnas. Methods Enzymol. 2000:318:88-104.
合成参考文献
摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 270. 摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2018) 2, 175. 摘要:Faber, K.; Glueck, S. M., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 1, 441.