CAS: 121-46-0; (1S,4S)-Bbicyclo[2.2.1]Hepta-2,5-Diene

该化合物是一种双环有机化合物,其独特结构由双环[2.2.1]-七二丁基框架组成,在室温下是一种无色液体,具有独特的气味.诺伯纳迪内因其能够进行 Diels-Alder反应,使其成为有机合成中的宝贵中间体而引人注目.该化合物相对稳定,但在某些条件下可以进行异构和聚合,特别是在接触热或光时.其分子配方为C7H8, 其沸点相对较低,导致其波动.诺伯纳迪内还关心材料科学,特别是开发具有光反应作用的聚合物,并将其作为先进材料的潜在建筑块.此外,由于能够对光暴露时进行可逆的转化,它在光化学领域也有应用.在处理诺布伦迪内时,应当采取安全防范措施,因为它可能刺激皮肤和眼睛.

结构式图片

欧盟法规

REACH注册ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

cyclopenta-1,3-diene acetylene methanol hept-5-eneendo-2,3-bis(phenylsulfonyl)bicyclo2.2.1hept-5-ene 5-formyloxy-2,6-cyclo-norbornan-3-ol 2,4.03,7]nonane-8,8,9,9-tetracarbonitriletetracyclo[4.3.0.02,4.03,7]nonane-8,8,9,9-tetracarbonitrile 2,6>heptan-3-ol3-(benzoyloxy)-tricyclo2.2.1.02,6heptan-3-ol Nortricyclylbromid

合成工艺路线路线简述

  • 合成目标产物 2,5-Norbornadiene 主要起始原料 Quadricyclane
  • (文献来源)合成步骤主要原料 Quadricyclane
Alkaline Earth Salt Of/the/ Methylsulfuric Acid 110.0~125.0 °C,8.0 Kpa 条件下,反应生成2,5-降冰片二烯
参考文献:Amine Oxides. Vi. The Formation Of 2,5-Norbornadiene And 2-Norbornene From 5-Dimethylamino-2-Norbornene And 2-Dimethylaminonorbornane1,2
标题:Amine Oxides. Vi. The Formation Of 2,5-Norbornadiene And 2-Norbornene From 5-Dimethylamino-2-Norbornene And 2-Dimethylaminonorbornane1,2
摘要:
Doi:10.1021/ja01520A047

海关参考信息

专利信息


专利号:US-10995049-B2
优先权日:2019-07-19
标 题 :Total synthesis of prostaglandin J natural products and their intermediates
发明人:LI JIAMING; XU CHEN; AHMED TONIA S; GRUBBS ROBERT H; STOLTZ BRIAN M
权利人:CALIFORNIA INST OF TECHN
摘要:The present disclosure is directed to methods of preparing prostaglandin J natural products by stereoretentive metatheses reactions and intermediates used in the synthesis of these natural products, including the use of intermediates of Formula (I-A), where R 1 is defined in the specification

专利号:US-12421534-B2
优先权日:2021-11-10
标 题 :Engineered enzymes and method for the synthesis of diverse tyrosine analogs
发明人:ALMHJELL PATRICK J; ARNOLD FRANCES H
权利人:CALIFORNIA INST OF TECHN
摘要:Provided herein is an engineered tryptophan synthase β-subunit (TrpB) that catalyzes the synthesis of tyrosine, tyrosine analogs, or salts thereof. Also provided herein are methods for preparing tyrosine, tyrosine analogs, or a salt thereof using the engineered TrpB described herein.

专利号:US-2016031800-A1
优先权日:2013-03-14
标 题:Synthesis of chiral kynurenine compounds and intermediates
发明人:TRETYAKOV ALEXANDER; DROUET KEITH E; SANDERS WILLIAM
权利人:VISTAGEN THERAPEUTICS INC
摘要:Provided are methods for the synthesis of compounds including chiral kynurenine compounds, intermediates useful for the synthesis thereof, and related compounds. For example, methods are provided for the synthesis of L-4-chlorokynurenine.

专利号:US-2022219156-A1
优先权日:2019-04-29
标题:Catalyst for the catalytic synthesis of urea
发明人:GLOTZBACH CHRISTOPH; TENHUMBERG NILS; EL HAWARY TAREK; MAKHYNYA YEVGENY; LEITNER WALTER; KLANKERMAYER JÜRGEN; SCHUMACHER HANNAH
权利人:THYSSENKRUPP IND SOLUTIONS AG; THYSSENKRUPP AG
摘要:A ruthenium-phosphine complex can be used as a catalyst in a method for the catalytic synthesis of urea. The method may comprise more particularly a reaction of formamide or of formamide with ammonia in the presence of the catalyst to form urea and hydrogen. Through the use of the ruthenium-phosphine complex as the catalyst, catalytic preparation of urea from formamide or from formamide with ammonia is provided for the first time. This allows for synthesis under mild conditions and virtually no formation of byproducts. Further, using an acid as a cocatalyst in the catalytic synthesis or the reaction can lead to an improvement in urea yield.

专利号:US-2003182068-A1
优先权日:2001-10-30
标 题 :Device and methods for directed synthesis of chemical libraries
发明人:BATTERSBY BRONWYN J; MILLER CHRISTOPHER R; TRAU MATHIAS; WAY JEFFERY C; JOHNSTON ANGUS
摘要:The invention features a sort computer which interfaces with a sorting device in order to control the sorting of beads on a bead by bead basis. The invention further features novel methods for the directed synthesis of encoded libraries of oligomers, e.g., oligonucleotides, on beads. These methods allow the synthesis of libraries that are sufficiently large to permit complex genomic analyses to be carried out. New methods of using the encoded libraries also are described.

专利号:US-2003162992-A1
优先权日:2001-12-14
标 题 :Preparation of intermediates useful in the synthesis of antiviral nucleosides
发明人:WATANABE KYOICHI A; DU JINFA
摘要:The present invention is an efficient process for the manufacture of α-acyloxyacetaldehyde, a key intermediate in the synthesis of 1,3-oxathiolane and 1,3-dioxolane nucleosides.
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合成参考文献


摘要:Koo, S., Science of Synthesis, (2010) 45, 1413.
摘要:Lin, W.-C.; Wu, Y.-T., Science of Synthesis, (2010) 45, 1034.
摘要:Lin, W.-C.; Wu, Y.-T., Science of Synthesis, (2010) 45, 1029.
摘要:Fringuelli, F.; Piermatti, O.; Pizzo, F.; Vaccaro, L., Science of Synthesis, (2010) 47, 561.
摘要:Razin, V. V., Science of Synthesis, (2010) 47, 888.
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