CAS: 106614-28-2; Methyl 2,4-Difluorobenzoate

相似化合物

1550-35-2 1583-58-0 56456-47-4

上下游产品

CAS号1583-58-0 2,4-二氟苯甲酸 | CAS号67-56-1 甲醇 | CAS号72482-64-5 2,4-二氟苯甲酰氯 | CAS号124-38-9 二氧化碳 | CAS号2265-93-2 2,4-二氟碘苯 | CAS号74-88-4 碘甲烷 | CAS号56456-47-4 2,4-二氟苯甲醇 | CAS号128272-26-4 2-氟-4-甲氧基苯甲酸甲酯 | CAS号204707-42-6 4-氟-2-甲氧基苯甲酸甲酯 | CAS号2150-41-6 2,4-二甲氧基苯甲酸甲酯 | CAS号125568-71-0 2,4-二氟-5-硝基苯甲酸甲酯

2,4-二氟苯甲酸置于氯化亚砜,硫酸,三乙胺体系中,用 二氯甲烷 用作溶剂,化学反应 0.2H,反应生成2,4-二氟苯甲酸甲酯
参考文献:布朗斯台德酸催化的芳族羧酸氯化
标题:布朗斯台德酸催化的芳族羧酸氯化
摘要:摘要 通过与作为催化剂的布朗斯台德酸反应,已经有效地进行了芳族羧酸与 Socl 2的氯化.基于这一发现,开发了一种比传统催化方法更便宜的高效催化方法.20 种底物被氯化,在很短的反应时间内提供了极好的收率.并且socl 2 /brønsted酸体系已用于更大规模的制备反应.提出了双重活化机制来证明socl 2 /brønsted酸不可替代的体系.
Doi:10.1080/10426507.2021.1903008

专利信息

专利号:US-9926291-B2
优先权日:2007-03-27
标 题 :Synthesis of thiohydantoins
发明人：OUERFELLI OUATHEK; DILHAS ANNA; YANG GUANGBIN; ZHAO HONG
权利人:SLOAN KETTERING INST CANCER RES
摘要:A novel synthesis of the anti-androgen, A52, which has been found to be useful in the treatment of prostate cancer, is provided. A52 as well as structurally related analogs may be prepared via the inventive route. This new synthetic scheme may be used to prepare kilogram scale quantities of pure A52.

专利号:US-2022073513-A1
优先权日:2018-12-29
标题:1h-pyrrolo[2,3-b]pyridine derivatives and related compounds as bcl-2 inhibitors for the treatment of neoplastic and autoimmune diseases
发明人：CHEN YI
权利人:NEWAVE PHARMACEUTICAL INC
摘要:The present invention relates to compounds of Formula (II) and more preferably to 1H-pyrrolo[2,3-b]pyridine derivatives of formula (III) and related compounds. The variables are defined in the claims. The compounds are BCL-2 inhibitors for treating neoplastic, autoimmune or neurodegenerative diseases. The present description discloses the synthesis of exemplary compounds as well as pharmacological data thereof (pages 61 to 72; examples 1 to 4; tables). An exemplary compound is e.g. 4-(4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl]piperazin-1-yl)-2-[methyl(1H-pyrrolo[2,3-b]pyridin-5-yl)phosphoroso]-N-[3-nitro-4-[(oxan-4-yl methyl)amino]benzenesulfonyl]benzamide (example 1).

专利号:WO-2008119015-A2
优先权日:2007-03-27
标 题 :Synthesis of thiohydantoins

专利号:US-8987452-B2
优先权日:2007-03-27
标 题:Synthesis of thiohydantoins

专利号:US-2023119463-A1
优先权日:2019-12-27
标题 :1h-pyrrolo[2,3-b]pyridine derivatives as bcl-2 inhibitors for the treatment of neoplastic and autoimmune diseases
发明人：CHEN YI
权利人:NEWAVE PHARMACEUTICAL INC
摘要:The present invention relates to 1H-pyrrolo[2,3-b]pyridine derivatives and related compounds as BCL-2 inhibitors for treating neoplastic, autoimmune or neurodegenerative diseases. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 162 to 233; examples 1 to 8; table; compound examples cpd-1 to cpd-135; biological examples 1 to 4).

专利号:US-2010190991-A1
优先权日:2007-03-27
标题 :Synthesis of thiohydantoins