甘油置于盐酸,溶剂黄146,Sodium Hydroxide体系中,用 水 用作溶剂,70.0~120.0 °C,101.33 Kpa 条件下,反应生成环氧氯丙烷 参考文献:Method For Preparing Chlorohydrins Composition And Method For Preparing Epichlorohydrin Using Chlorohydrins Composition Prepared Thereby 标题:Method For Preparing Chlorohydrins Composition And Method For Preparing Epichlorohydrin Using Chlorohydrins Composition Prepared Thereby 摘要:提供了一种制备氯水合物组合物的方法以及利用该方法制备环氧氯丙烷的方法.制备氯水合物组合物的方法包括在催化剂存在下,将多羟基脂肪烃类烃烃基化试剂反应,包括按照规定顺序执行至少一个系列单元操作的组合,其中该方法还包括混合从最终反应步骤排放的反应混合物经纯化得到的氯水合物浓缩物和从脱水步骤排放的富水层.制备环氧氯丙烷的方法包括将通过制备氯水合物组合物的方法制备的氯水合物组合物与碱性试剂接触.
专利号:WO-2023152730-A1 优先权日:2022-02-14 标题 :Amine-borane adducts in the synthesis of polyester and its copolymers using cyclic esters and compositions thereof 发明人:FENG XIAOSHUANG; LIU JINGJING; GNANOU YVES 权利人:UNIV KING ABDULLAH SCI & TECH 摘要:Embodiments of the present disclosure provide for the process of synthesis of polyester and its copolymers through (co)polymerization of cyclic esters and with other oxygenated monomers using amine-borane adduct. Embodiments of the present disclosure further describe the controlled anionic ring-opening polymerization of the cyclic compounds. Embodiments of the present disclosure also describe the polymerization of cyclic compounds using the synergistic effect of amines and thioureas. Embodiments of the present disclosure also describe compositions of polymers formed by the said process.
专利号:US-8969619-B2 优先权日:2009-07-21 标题:Synthesis of iodixanol in propyleneglycol 发明人:JOHNSEN HANNE JORUNN H; HOLMAAS LARS TERJE; KJERNLI TROND; HOMESTAD OLE MAGNE 权利人:JOHNSEN HANNE JORUNN H; HOLMAAS LARS TERJE; KJERNLI TROND; HOMESTAD OLE MAGNE; GE HEALTHCARE AS 摘要:This invention relates to the synthesis of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the dimerisation of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide with propyleneglycol as solvent.
专利号:WO-2024170663-A1 优先权日:2023-02-15 标 题:Organic reinforcement of an elastomer with the in situ synthesis of a polyimide phase by reactive extrusion 发明人:CASSAGNAU PHILIPPE; DELAGE KARIM; BOUNOR-LEGARE VÉRONIQUE; MARESTIN CATHERINE; DUBOIS CHARLOTTE; GAROIS NICOLAS 权利人:TOTALENERGIES ONETECH; UNIV CLAUDE BERNARD LYON 1 UCBL; CENTRE NAT RECH SCIENT; UNIV JEAN MONNET SAINT ETIENNE; INSTITUT NAT DES SCIENCES APPLIQUEES DE LYON INSA LYON 摘要:The present disclosure relates to a process to produce a reinforced elastomeric material and to the reinforced elastomeric material. The process comprises the steps of providing components comprising a grafted elastomer, one or more dianhydrides, and one or more diamines; wherein the grafted elastomer is provided at a content of at least 60 wt.% based on the total weight of the components; performing in situ synthesis of a polyimide phase in the grafted elastomer by reactive extrusion of the components in a twin-screw extruder comprising main hopper wherein the screw profile comprises two or more reverse conveying elements forming two or more hot zones to form an elastomer-polyimide blend; and recovering said elastomer-polyimide blend being a reinforced elastomeric material.
专利号:US-7696381-B1 优先权日:2009-07-21 标题 :Alternative dimerisation reagents for synthesis of iodixanol 发明人:BERG ARNE; DUGSTAD HARALD; GACEK MICHEL; GULBRANDSEN TRYGVE; STRANDE PER 权利人:GE HEALTHCARE AS 摘要:This invention relates generally to non-ionic X-ray contrast agents. It further relates to the synthesis of iodixanol. In particular, it relates to alternative dimerisation reagents in the conversion of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound Aâ€?) to iodixanol.
专利号:US-8962886-B2 优先权日:2009-07-21 标题:Synthesis of iodixanol in methanol 发明人:JOHNSEN HANNE JORUNN H; HOLMAAS LARS TERJE; HOMESTAD OLE MAGNE 权利人:JOHNSEN HANNE JORUNN H; HOLMAAS LARS TERJE; HOMESTAD OLE MAGNE; GE HEALTHCARE AS 摘要:This invention relates to the synthesis of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the dimerisation of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide with methanol as solvent.
专利号:US-9556140-B2 优先权日:2013-01-26 标 题 :Approach for synthesis of catechins 发明人:DUGAR SUNDEEP; MAHAJAN DINESH; RAI KUMAR SANTOSH; TRIPATHI VINAYAK; PATIL ISHWAR RAKESH 权利人:SPHAERA PHARMA PRIVATE LTD 摘要:A process for synthesis of enatiomerically pure or enatiomerically enriched or racemic mixture of (+ and/or −) epicatechin and its intermediates, comprising the steps of: (i) obtaining penta-protected quercetin; (ii) reducing the penta-protected quercetin obtained from step (i); (iii) optionally deprotecting the compound of step (ii); (iv) reducing the compound obtained from step (ii) or step (iii) in the presence of a chiral/achiral reducing agent to obtain a chiral intermediate; (v) deprotecting and/or hydrogenation of the chiral intermediate obtained from step (iv) to obtain (−)-epicatechin; (vi) optionally simultaneously deprotecting and by drogenation of the compound obtained from step (ii) to obtain racemic epicatechin.
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