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参考文献:Prolyl Hydroxylase Inhibitors And Methods Of Use
标题:Prolyl Hydroxylase Inhibitors And Methods Of Use
摘要:本公开涉及hif-1α脯氨酸羟化酶抑制剂,包括组成其中的hif-1α脯氨酸羟化酶抑制剂的组合物以及用于控制周围血管疾病(pvd),冠状动脉疾病(cad),心力衰竭,缺血和贫血等疾病的方法.
专利信息
专利号:US-9957277-B2
优先权日:2015-11-25
标题 :eIF4A-inhibiting compounds and methods related thereto
发明人:ERNST JUSTIN T; REICH SIEGFRIED H; SPRENGELER PAUL A; TRAN CHINH VIET; PACKARD Garrick Kenneth; XIANG ALAN X; NILEWSKI CHRISTIAN; MICHELS THEO
权利人:EFFECTOR THERAPEUTICS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. n nFor Formula I compounds X, Y, R 1 , R 2 , R 3a , R 3b , R 4a , R 4b and R 5 are as defined in the specification. The inventive Formula I compounds are inhibitors of eIF4A and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.