2142-79-2 + 100-66-3 = 100-06-1 反应条件:1.1 Catalysts: Trifluoromethanesulfonic Acid Solvents: 1-Ethyl-3-Methylimidazolium Tetrafluoroborate; 0 °C; 4 H,70 °C 标题:Triflic Acid-Promoted Transacylation And Deacylation Reactions In Ionic Liquid Solvents 作者:Sarca,Viorel D.; Laali,Kenneth K. 参考文献:Green Chemistry 日期:2004 卷标:6(5) 页码:245-248
茴香烯置于四氟硼酸-二乙醚络合物,亚碘酰苯,碘,Silver(L) Oxide体系中,用 1,4-二氧六环,乙醚,水 用作溶剂,化学反应 241.0H,反应生成对甲氧基苯乙酮 参考文献:Oxidative Cleavage Of α-Aryl Aldehydes Using Iodosylbenzene 标题:Oxidative Cleavage Of α-Aryl Aldehydes Using Iodosylbenzene 摘要:We Found That A-Aryl Aldehydes Can Be Cleaved To Chain-Shortened Carbonyl Compounds And Formaldehyde By Various Iodosylbenzene Complexes. A Mechanistic Scheme Is Presented That Accounts For The Loss Of One Carbon Atom. Formaldehyde Is Further Oxidized To Co And Co2 Under The Reaction Conditions. Doi:10.1021/ol301675V
专利信息
专利号:US-2012215002-A1 优先权日:2009-10-09 标 题:Synthesis of optically active intermediate for the preparation of montelukast 发明人:LEFORT LAURENT 权利人:LEFORT LAURENT 摘要:The present invention relates to the synthesis of optically active alcohols by means of enantioselective hydrogenation of ketones in biphasic systems. In particular the present invention relates to the synthesis of an optically active alcohol of general formula (1).
专利号:US-11999757-B2 优先权日:2017-11-01 标 题:Synthesis of boronate ester derivatives and uses thereof 发明人:BOYER SERGE HENRI; HECKER SCOTT J; VERZIJL GERARDUS K M; HERMSEN PETRUS J 权利人:MELINTA SUBSIDIARY CORP 摘要:Disclosed herein are methods for the preparation of boronate derivatives in the synthesis of antimicrobial compounds and uses thereof. Disclosed herein includes method of making a compound of Formula (B) by reducing the ketone group of the keto-ester compound of Formula (A), and the reduction can be performed using a Ruthenium based catalyst system or using an alcohol dehydrogenase bioreduction system.
专利号:US-10669292-B2 优先权日:2014-05-05 标 题 :Synthesis of boronate salts and uses thereof 发明人:HECKER SCOTT; BOYER SERGE 权利人:REMPEX PHARMACEUTICALS INC 摘要:Disclosed herein are boronate intermediates in the synthesis of antimicrobial compounds and the use and preparation thereof. Some embodiments relate to crystalline boronate salt derivatives and their use in the synthesis of therapeutic compounds.
专利号:US-10280189-B2 优先权日:2012-07-17 标题:Method for the synthesis of aminoalkylenephosphonic acid 发明人:BURCK SEBASTIAN; LECLERCQ CEDRIC NICOLAS; NOTTE PATRICK 权利人:MONSANTO TECHNOLOGY LLC 摘要:A method for the synthesis of an aminoalkylenephosphonic acid or its phosphonate esters including the following steps: a) forming, in the presence of an aldehyde or ketone and an acid catalyst, a reaction mixture by mixing a compound having at least one HNR 1 R 2 moiety or a salt thereof, with a compound having one or more P—O—P anhydride moieties, the moieties having one P atom at the oxidation state (+III) and one P atom at the oxidation state (+III) or (+V), wherein the ratio of moles of aldehyde or ketone to N—H moieties is 1 or more and wherein the ratio of N—H moieties to P—O—P anhydride moieties is 0.3 or more, and b) recovering the resulting aminoalkylenephosphonic acid having compound or its phosphonate esters.
专利号:US-8263784-B2 优先权日:2008-10-30 标 题 :Method for the synthesis of a ramipril intermediate 发明人:DE LANGE BEN; HEEMSKERK DENNIS 权利人:DE LANGE BEN; HEEMSKERK DENNIS; DSM SINOCHEM PHARM NL BV 摘要:The present invention relates to a process for the preparation of octahydrocyclopenta[b]pyrrole-2-carboxylic acid and esters thereof of general formula (1) in the presence of a cobalt and/or nickel comprising catalyst and to the use of compounds of general formula (1) in the synthesis of ramipril.
专利号:US-10487099-B2 优先权日:2017-06-30 标 题:Synthesis of hypervalent iodine reagents with dioxygen 发明人:POWERS DAVID CHARLES; MAITY ASIM; HYUN SUNG-MIN 权利人:TEXAS A & M UNIV SYS 摘要:Methods of synthesis of hypervalent iodine reagents and methods for oxidation of organic compounds are disclosed.