CAS: 853179-74-5; 2-Bromo-6-Methylnicotinaldehyde

该化合物是一种有机化合物,其特点是有刺状环状结构,包括一个溴原子和一个在特定位置的甲基组;甲醛功能组(CHO)的存在表明,这是一种反应性化合物,能够参与各种化学反应,例如核生殖器添加物;该化合物通常呈现黄色至褐色的灰色,在乙醇和二氯甲烷等有机溶剂中可溶解,但由于其疏水特性,水溶性有限;其分子结构有助于其在有机合成中的潜在应用,特别是在制药和农用化学的开发中.该溴亚化合物可增强再活性,使其在交叉反应中有用.此外,该化合物的独特特性可能允许生物系统中的特定互动,从而需要对其生物活动和医药化学的潜在用途作进一步调查.在处理该化合物时,应采取安全防范措施,因为其反应性和潜在毒性可能给健康带来风险.

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155265-57-9 885277-48-5 1060810-09-4

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CAS号155265-57-9 2-溴-6-甲基烟腈 | CAS号4241-27-4 3-氰基-6-甲基-2(1H)-吡啶酮

合成工艺路线路线简述

  • 155265-57-9 = 853179-74-5
    反应条件:1.1 Reagents: Diisobutylaluminum Hydride Solvents: Dichloromethane; -78 °C
    标题:A New Approach To The 1,10-Phenanthroline Core
    作者:Chelucci,Giorgio; Et Al
    参考文献:Tetrahedron Letters 日期:2007 卷标:48(19) 页码:3359-3362]

    155265-57-9 = 853179-74-5
    反应条件:1.1 Reagents: Diisobutylaluminum Hydride Solvents: Toluene; Rt -> -60 °C; 45 Min,< -50 °C; 2.5 H,-50 °C1.2 Reagents: Sulfuric Acid Solvents: Toluene,Tetrahydrofuran,Water; 16 H,Rt
    标题:Efficient And Fast Heck Vinylation Of 2-Bromo-6-Methyl Pyridines With Methylacrylate. Application To The Synthesis Of 6-Methyl Cyclopenta[b]Pyridinone
    作者:Robert,Nicolas; Et Al
    参考文献:Tetrahedron 日期:2005 卷标:61(19) 页码:4569-4576]

    4241-27-4 = 853179-74-5
    反应条件:1.1 Reagents: Phosphorus Pentoxide,Tetrabutylammonium Bromide Solvents: Toluene; 4 H,Reflux2.1 Reagents: Diisobutylaluminum Hydride Solvents: Dichloromethane; -78 °C
    标题:A New Approach To The 1,10-Phenanthroline Core
    作者:Chelucci,Giorgio; Et Al
    参考文献:Tetrahedron Letters 日期:2007 卷标:48(19) 页码:3359-3362
📜2-溴-3-氰基-6-甲基吡啶置于二异丁基氢化铝,硫酸体系中,用 甲苯,四氢呋喃 作为反应溶剂,化学反应 18.5H,以93%的收率获得产物2-溴-6-甲基吡啶-3-甲醛
参考文献:Efficient And Fast Heck Vinylation Of 2-Bromo-6-Methyl Pyridines With Methylacrylate. Application To The Synthesis Of 6-Methyl Cyclopenta[b]Pyridinone
标题:Efficient And Fast Heck Vinylation Of 2-Bromo-6-Methyl Pyridines With Methylacrylate. Application To The Synthesis Of 6-Methyl Cyclopenta[b]Pyridinone
摘要:Heck Vinylation Of 2-Bromo-6-Methyl-3-Substituted Pyridines Using Eta(3)-Allylpalladium Chloride Dimer/p(O-Tol)(3) Complex/toluene And Dimethylacetamide (Dma) As Co-Solvent With Methyl Acrylate Is Reported. Electronic And Steric Effects Were Investigated Engaging Diversely 2-Bromo-3,6-Disubstituted Pyridines. As Application,A New Synthesis Of The 6-Methyl Cyclopenta[b]Pyridinone Building-Block Connecting Heck Vinylation,Alkene Reduction And Dieckmann Condensation Is Described. (C) 2005 Published By Elsevier Ltd.
DOI:10.1016/j.Tet.2005.03.008

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主要参考文献

参考标题:Synthesis Of Stereodefined 1-Aryl(Heteroaryl) Substituted 1,2-Bis(2-Bromopyridin-3-Yl)Ethenes By Selective Tandem Suzuki-Miyaura Cross-Coupling Reactions
作者:Giorgio Chelucci,Salvatore Baldino |发布日期:2008.4
摘要:A Protocol For The Synthesis Of Stereodefined 1-Aryl(Heteroaryl) Substituted 1,2-Bis(2-Bromopyridin-3-Yl)Ethenes By Tandem Suzuki-Miyaura Cross-Coupling Reactions And An Example Of Convention Into 5-Phenyl-1,10-Phenanthroline Are Described.

合成参考文献

参考DOI号:10.1016/j.tet.2005.03.008
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