CAS: 73080-51-0; Isopentyl 7,8-Dimethyl-4,5-Dioxo-5,6-Dihydro-4H-Pyrano[3,2-C]Quinoline-2-Carboxylate

该化合物是一种化学化合物,被归类为抗脊髓灰质炎,主要以其作为酶磷化酶选择性抑制剂的作用而著称;由于它能够调节炎症反应,因此经常研究其在治疗过敏症和哮喘方面的潜在治疗应用;该化合物的特性可以提高循环AMP水平,它在各种细胞过程中发挥着关键作用,包括调节肌肉平稳收缩和...

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CAS号63768-46-7 3-acetyl-4-hydr... | CAS号87-59-2 2,3-二甲基苯胺 | CAS号63768-47-8 5,6-二氢-7,8-二甲基-... | CAS号123-51-3 异戊醇 | CAS号73080-52-1 quinoline-2-car...

合成工艺路线路线简述

    5,6-二氢-7,8-二甲基-4,5-二氧代-4H-吡喃并[3,2-C]喹啉-2-甲酸置于氯化亚砜体系中,化学反应 9.0H,反应生成 瑞吡司特
    参考文献:Morinaka; Takahashi; Hata,European Journal Of Medicinal Chemistry,1981,Vol. 16,# 3,P. 251-256
    标题:Morinaka; Takahashi; Hata,European Journal Of Medicinal Chemistry,1981,Vol. 16,# 3,P. 251-256

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    专利信息


    专利号:US-2003138490-A1
    优先权日:2001-09-08
    标 题 :Synthesis and uses of polymer gel nanoparticle networks
    发明人:HU ZHIBING; LU XIHUA; GAO JUN; PONDER BILL C; JOHN JOHN ST; MORO DANIEL G
    摘要:Disclosed is a new class of nanostructured polymeric materials comprising polymer gel nanoparticles that are covalently bonded through functional groups on the surfaces of neighboring particles. These nanoparticles may be prepared as suspensions in an aqueous or, non-aqueous environment. These gels have two unique and different structural networks; the primary network comprises crosslinked polymer chains in each individual particle, while the secondary network is a system of crosslinked nanoparticles. Particular polymer gel nanoparticle network compositions disclosed herein may function as carriers for controlled delivery of pharmaceuticals or other chemical agents, gel sensors and other commercial applications.

    专利号:US-2014315720-A1
    优先权日:2012-10-24
    标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
    发明人:FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
    权利人:CELANESE ACETATE LLC
    摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

    专利号:WO-03022910-A1
    优先权日:2001-09-08
    标题:Synthesis and uses of polymer gel nanoparticle networks
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    主要参考文献


    1: Shishikura T, Shito K, Uchida M, Inaba T. A late cutaneous response in actively sensitized rats: a new method for evaluating the efficacy of antiallergic drugs. J Pharmacol Sci. 2006 Aug;101(4):350-5. doi: 10.1254/jphs.fp0060519. Epub 2006 Aug 5. 49(6):472-8. Japanese. 28(3):411-4. doi: 10.1016/s0306-3623(96)00298-4. 46(9):884-6. 16(3A):1241-5. 45(1):33-5. 73(1):21-6. 188(2):117-21. doi: 10.1159/000247114. 63(1):73-81. doi: 10.1254/jjp.63.73. 100(4):367-72. doi: 10.1159/000236440. 82(1):107-9. doi: 10.1002/jps.2600820123. 90(5):782-8. doi: 10.1016/0091-6749(92)90102-8. 44(6):1211-3. doi: 10.1016/0006-2952(92)90387-x. 43(5):1109-17. doi: 10.1016/0006-2952(92)90619-t. 105(3):587-90. doi: 10.1111/j.1476-5381.1992.tb09023.x.
    16: Beermann D, Schaefer HG, Wargenau M, Heibel B, Sturm Y, Kuhlmann J. Pharmacokinetics of the active metabolite of the prodrug repirinast in healthy Caucasian volunteers after a single oral dose. Eur J Clin Pharmacol. 1992;42(3):307-12. doi: 10.1007/BF00266353. 100(1):57-62. doi: 10.1378/chest.100.1.57. 29(4):413-9. Japanese. 20(1):66-80. doi: 10.2165/00003088-199120010-00005. 52(1):101-8. doi: 10.1254/jjp.52.101.

    合成参考文献


    参考文献:10.1007/bf01466275
    摘要:Lotens WA. Simulation of hand cooling due to touching cold materials. Eur J Appl Physiol Occup Physiol. 1992;65(1):59–65. doi: 10.1007/bf01466275.
    参考文献:10.1007/bf02171427
    摘要:Pringle CR, Stewart JM. Rate of respiration in relation to autogamy inParamecium aurelia. Cellular and Molecular Life Sciences. 1961 Feb;17(2):73–5. doi: 10.1007/bf02171427.
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