CAS: 68236-20-4; 2-Chloro-7-Methoxyquinoline-3-Carbaldehyde

该化合物是一种多用途的quinoline衍生物,在有机合成和制药研究方面有很大用途,其结构以2位置的氯替代物和7位置的甲氧基组为特色,增强了交叉反应和环球变的回动性和选择性.3位置的甲醛功能是进一步衍生的关键中间体,能够合成复杂的生物活性分子.这种复合物在标准条件下表现出稳定性,在药用药剂和农用化学的开发中特别宝贵.其定义明确的再活动特征使得研究人员更愿意探索新型的quinoline型蓝宝石.

结构式图片

相似化合物

128259-63-2 155983-20-3 73568-29-3

物理性质

MSDS等安全信息

上下游产品

CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号588-16-9 3'-甲氧基乙酰苯胺 | CAS号536-90-3 间氨基苯甲醚 | CAS号101382-55-2 2-羟基-7-甲氧基喹啉-3-醛 | CAS号128259-63-2 2-氯-7-甲氧基-喹啉-3-甲腈 | CAS号101382-55-2 2-羟基-7-甲氧基喹啉-3-醛 | CAS号333408-48-3 2-氯-7-甲氧基喹啉-3-甲醇 | CAS号136812-28-7 8-溴-2-氯-7-甲氧基喹啉-3-羧醛 | CAS号72808-91-4 7-甲氧基-喹啉-3-甲醛 | CAS号95395-38-3 5-[(7-methoxyqu...

合成工艺路线路线简述

    📜2-羟基-7-甲氧基喹啉-3-甲醛置于三氯氧磷体系中,化学反应生成 2-氯-7-甲氧基喹啉-3-甲醛
    参考文献:Srivastava,Ambika; Singh,Indian Journal Of Chemistry-Section B Organic And Medicinal Chemistry,2005,Vol. 44,# 9,P. 1868-1875
    标题:Srivastava,Ambika; Singh,Indian Journal Of Chemistry-Section B Organic And Medicinal Chemistry,2005,Vol. 44,# 9,P. 1868-1875

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    专利信息


    专利号:US-7193086-B2
    优先权日:2001-05-30
    标题:Process for preparation of a quinolinecarbaldehyde
    发明人：MATSUMOTO HIROO; SHIMIZU TAKANORI
    权利人:DAICEL CHEM
    摘要:A process for producing 2-cyclopropyl-4-(4-fluorophenyl)-quinoline-3-carbaldehyde important as intermediate for the synthesis of pharmaceuticals, efficiently from an unnecessary antipode, is provided. n A process for producing 2-cyclopropyl-4-(4-fluorophenyl)-quinoline-3-carbaldehyde represented by the formula (III): n nwhich comprises treating a compound represented by the formula (I) or (II):n n n(wherein A is —CHOH or —C(O)—, and R is a hydrogen atom, a C 1-4 alkyl group which may be branched, a phenyl group, an alkali metal ion or an alkaline earth metal ion) with ozone, followed by reduction with an inorganic sulfur compound or by hydrogenation for reduction decomposition.

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    合成参考文献


    参考文献:10.1134/s1070428015100152
    摘要:Melik-Ohanjanyan RG, Hovsepyan TR, Israelyan SG, Karakhanyan GS, Minasyan NS. Annulation of 6-aminouracils with 2,3-dimethoxy- and 2-fluorobenzaldehydes and 2-chloro-7-methoxyquinoline-3-carbaldehyde. Russian Journal of Organic Chemistry. 2015 Oct;51(10):1444–8. doi: 10.1134/s1070428015100152.
    参考文献:10.1007/s10870-012-0325-6
    摘要:Guenfoud F, Direm A, Laabassi M, Benali-Cherif N. Synthesis of New Cyano-Quinoline Derivatives by the Baylis–Hillman Reaction. Journal of Chemical Crystallography. 2012 Aug 04;42(10):989–96. doi: 10.1007/s10870-012-0325-6.
    参考文献:10.1007/s00044-020-02645-x
    摘要:Vennila KN, Selvakumar B, Satish V, Sunny D, Madhuri S, Elango KP. Structure-based design, synthesis, biological evaluation, and molecular docking of novel 10-methoxy dibenzo[b,h][1,6]naphthyridinecarboxamides. Medicinal Chemistry Research. 2020 Oct 11;30(1):133–41. doi: 10.1007/s00044-020-02645-x.
    参考文献:10.1007/s11094-022-02688-x
    摘要:Chandrashekharappa S, Sadashiv SO, Patil SJ, Nandeshwarappa BP. Design and Synthesis of New Series of 2-Oxo-2H-Selenopyrano[2,3-b]Quinoline-3-Carboxylates and Evaluation of Their Antibacterial Activity. Pharmaceutical Chemistry Journal. 2022 Aug 16;56(5):638–44. doi: 10.1007/s11094-022-02688-x.
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