CAS: 642-18-2; Alstonine

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    maleic acid19α-methyl-(20α)-18-oxa-yohimb-16-ene-16-carboxylic acid methyl ester tetrahydroalstonine tetrahydroalstonial

    合成工艺路线路线简述

      📜顺丁烯二酸,Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于水,钯体系中,化学反应生成 鸭脚木碱,鸡骨常山碱
      参考文献:Oxidation-Reduction Studies In The Realm Of Indole Alkaloids1,2
      标题:Oxidation-Reduction Studies In The Realm Of Indole Alkaloids1,2
      摘要:
      DOI:10.1021/ja01540A027

      海关参考信息

      专利信息


      专利号:US-2009011476-A1
      优先权日:2005-08-19
      标 题 :Gene cluster and method for the biosynthesis of terrequinone a
      发明人:HOFFMEISTER DIRK; KELLER NANCY P
      权利人:WISCONSIN ALUMNI RES FOUND
      摘要:The present invention provides a novel gene cluster containing five genes (tdiA-E) involved in indole alkaloid synthesis. Disruption of tdiB, encoding an enzyme with prenyltransferase activity, transferring dimethylallylpyrophosphate to C-2 of an indole structure, eliminated the production of the antitumor compound terrequinone A, a metabolite not known from A. nidulans . The invention further provides a method for expressing terrequinone A in a host cell and isolating purified terrequinone A therefrom.

      专利号:US-2024299945-A1
      优先权日:2021-09-03
      标题 :Multi-way bead-sorting devices, systems, and methods of use thereof using pressure sources
      发明人:HILL MATTHEW; UNGER MARC; WAHBA ASHRAF; CAEN OURIEL E
      权利人:ELEGEN CORP
      摘要:Embodiments relate to devices, systems, methods and compositions useful for routing and tracking multiple mobile units within a microfluidic device having an inlet channel connected to a multi-way sorting junction, which is fluidly connected with a plurality of 4 or more channels, and a steering mechanism for directing the flow of the mobile units according to a predetermined algorithm. Mobile units can be routed and followed through the microfluidic device in an ordered flow, such that the mobile units are exposed to chemical environments and/or enzymatic synthesis reactions associated with the channels. Mobile units can be steered in multiple directions, between the sorting junctions and the channels by the steering mechanism by changes in flow or pressure. Some such devices, systems, methods and compositions include mobile units that can flow in both the forward and reverse directions and into each of as plurality of 4 or more channels from two sorting junctions.

      专利号:CN-107417595-A
      优先权日:2017-03-27
      标题:A method for the synthesis of a series of monoterpene indole alkaloid skeletons and natural products based on free radical tandem reactions

      专利号:EP-0059817-B1
      优先权日:1981-03-11
      标 题 :Serpentine, alstonine and sempervirine drugs for the specific inhibition of tumurous and cancerous cells
      摘要:1. Pharmaceutical compositions having preferential action on the replication of DNA and the synthesis RNA in tumorous, cancerous and viral cells, characterized in that they consist of microgranules having a neutral central core, at least one first intermediary layer comprising at least one alkaloid of the group of beta-carbolines of the type serpentine, alstonine, sempervirine and flavopereirine, and at least an outer layer made up by a microporous envelope, comprising at least a natural and/or synthetic polymer of the type : shellac, arabic gum, gelatine, cellulose, ethyl cellulose, cellulose acetophtalate, cellulose triacetate, polyvinyl pyrrolidone, polyoxyethylene glycol, methacrylates and styrene-acrylonitrile copolymers.

      专利号:ES-2940580-B2
      优先权日:2021-11-05
      标题:MICROFLUIDIC CHIP FOR THE IN-SITU SYNTHESIS OF SILVER NANOSTARS WITH PLASMONIC PROPERTIES FOR SERS ANALYSIS

      专利号:CN-219518794-U
      优先权日:2023-02-14
      标题:A new type of low pressure drop nitric acid purifier for oxo synthesis of DMO

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      ✅ COA系统入驻 | 共享模式

      主要参考文献


      1: Linck VM, Ganzella M, Herrmann AP, Okunji CO, Souza DO, Antonelli MC, Elisabetsky E. Original mechanisms of antipsychotic action by the indole alkaloid alstonine (Picralima nitida). Phytomedicine. 2015 Jan 15;22(1):52-5. doi: 10.1016/j.phymed.2014.10.010. Epub 2014 Nov 6. doi: 10.1107/S1600536813021168. eCollection 2013.
      3: Herrmann AP, Lunardi P, Pilz LK, Tramontina AC, Linck VM, Okunji CO, Gonçalves CA, Elisabetsky E. Effects of the putative antipsychotic alstonine on glutamate uptake in acute hippocampal slices. Neurochem Int. 2012 Dec;61(7):1144-50. doi: 10.1016/j.neuint.2012.08.006. Epub 2012 Aug 25. doi: 10.1016/j.pnpbp.2011.08.022. Epub 2011 Sep 8. doi: 10.1093/ecam/nep002. Epub 2011 Jun 23.
      6: de Moura Linck V, Herrmann AP, Goerck GC, Iwu MM, Okunji CO, Leal MB, Elisabetsky E. The putative antipsychotic alstonine reverses social interaction withdrawal in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Aug 1;32(6):1449-52. doi: 10.1016/j.pnpbp.2008.04.013. Epub 2008 Apr 29. Epub 2006 Jan 16.

      合成参考文献


      参考文献:10.1021/jo01200a015
      摘要:HAWKINS WL, ELDERFIELD RC. ALSTONIA ALKALOIDS. II. A NEW ALKALOID, ALSTONILINE, FROM A. CONSTRICTA. J. Org. Chem. 1942 Nov;07(6):573–80. doi: 10.1021/jo01200a015.
      参考文献:10.1016/s0021-9673(00)90403-5
      摘要:Ferrari M, Verotta L. Centrifugal thin-layer chromatography of alkaloids from vegetable sources using an aluminium oxide layer. Journal of Chromatography A. 1988 Jan;437():328–32. doi: 10.1016/s0021-9673(00)90403-5.
      参考文献:10.3987/r-1981-10-1727
      摘要:Siddiqui S, Malik A, afza N. Structure and Absolute Configuration of Serpenticine, a New Anhydronium Base from Rauwolfia vomitoria Afzuelia. HETEROCYCLES. 1981;16(10):1727. doi: 10.3987/r-1981-10-1727.
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