CAS: 552-59-0; 5-Hydroxy-3-(4-Hydroxyphenyl)-7-Methoxy-4H-Chromen-4-One

该化合物是一种天然的科马林衍生物,其特征是苯丙酰激素结构,由结合的苯并苯和环组成,具有一系列生物活动,包括抗氧化剂,抗炎和抗微生物特性,这使其在药理研究中感兴趣.氢氧基组的存在增强了其在极地溶剂中的再活性和溶性,而甲基氧组则有助于其稳定性和脂性.Umbelliferone由于能够吸收紫外线,经常受到研究,特别是在癌症研究和皮肤保护领域.此外,它存在于各种植物中,有助于其药学特性.它的化学行为可能受到环境因素的影响,并且经常被用作生物化学化学化学学中的荧光探测器.

结构式图片

上下游产品

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on dimethyl sulfate 4',5,7-trimethoxyisoflavone H-chromene-2-carboxylic acid5-hydroxy-3-(4-hydroxy-phenyl)-7-methoxy-4-oxo-4H-chromene-2-carboxylic acid4',7-dimethoxy-5-hydroxyisoflavone 3-(4-acetoxy-phenyl)-5-hydroxy-7-methoxy-chromen-4-one 4',5,7-trimethoxyisoflavone 2,6,4'-trihydroxy-4-methoxy-deoxybenzoin

合成工艺路线路线简述

    📜对羟基苯乙腈置于吡啶,盐酸,Potassium Carbonate,苯体系中,化学反应生成 樱黄素
    参考文献:Baker Et Al.,Journal Of The Chemical Society,1953,P. 1852,1856
    标题:Baker Et Al.,Journal Of The Chemical Society,1953,P. 1852,1856

    海关参考信息

    专利信息


    专利号:US-10030003-B2
    优先权日:2014-09-10
    标 题:Synthesis of isoflavanes and intermediates thereof
    发明人:BELIAEV NIKOLAI; SHAFRAN YURI
    权利人:SYSTEM BIOLOGIE AG
    摘要:Subject of the invention is a method for enantioselective production of an isoflavane from an isoflavone, comprising the steps: (a) selectively reducing the isoflavone, such that the 4-keto group of the isoflavone is converted to a 4-hydroxy group, and the 2,3-double bond of the isoflavone is converted to a 2,3-single bond, thereby obtaining a 4-hydroxy intermediate, and (b) reacting the 4-hydroxy intermediate with a chiral reagent, such that a chiral group is covalently attached to the C4-position of the 4-hydroxy intermediate, thereby obtaining a chiral intermediate. The invention also relates to intermediates of formulae (IV), (V), (VI) and (VII) obtainable in the inventive process.

    专利号:US-8969596-B2
    优先权日:2008-08-14
    标题:Synthesis of equol
    发明人:STEFFAN BERT
    权利人:STEFFAN BERT
    摘要:Subject of the invention is a method for the production of isoflavanes from isoflavones, whereby in a first reaction step (a) the 4-keto group of the isoflavone is reduced in a enantioselective manner, whilst the 2,3-double bond is maintained, to the 4-hydroxy compound.

    专利号:US-2007232495-A1
    优先权日:2006-03-24
    标题:Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof
    发明人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
    权利人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
    摘要:The invention is related to compositions and methods that naturally protect plant tissues against ultraviolet radiation and temperature, thus giving protection against sunburn to plants, plant parts, fruits and/or flowers during their development. The invention is also related to compositions and methods to naturally improve the color of plants, plant parts, fruits and/or flowers by inducing the natural synthesis of flavonoids and anthocyanins present in plants. Likewise, the present invention is directed to improving the nutritional value of plants, plant parts, fruits and/or flowers by increasing the normal levels of polyphenolic compounds, especially flavonoids, present therein. Additionally, the present invention is related to compositions and methods that give more resistance to plants, plant parts, fruits and/or flowers against pathogens as bacteria and fungi. Finally, the present invention is related to plants, plant parts, fruits, flowers and/or propagating material treated with the compositions described in the present document.

    专利号:US-2012094336-A1
    优先权日:2008-08-14
    标题:Synthesis of equol

    专利号:CA-2960437-A1
    优先权日:2014-09-10
    标 题 :Synthesis of isoflavanes and intermediates thereof

    专利号:WO-2006053688-A1
    优先权日:2004-11-17
    标 题:Cosmetic and dermatological preparations for the treatment of mature skin
    发明人:DOERING THOMAS
    权利人:HENKEL KGAA; DOERING THOMAS
    摘要:The invention relates to topical cosmetic or dermatological compositions for the treatment of mature or intrinsically or extrinsically aged skin, in particular, for anti-wrinkle treatment, containing a combination of at least two selected peptides in a suitable cosmetic or dermatological vehicle, which have an effect at differing points of the process of collagen and/or fibronectin synthesis.

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    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Hamed AB, El-Abhar HS, Abdallah DM, Ahmed KA, Abulfadl YS. Prunetin in a GPR30-dependent manner mitigates renal ischemia/reperfusion injury in rats via interrupting indoxyl sulfate/TLR4/TRIF, RIPK1/RIPK3/MLKL, and RIPK3/PGAM5/DRP-1 crosstalk. Saudi Pharm J. 2023 Nov;31(11):101818. doi: 10.1016/j.jsps.2023.101818. Epub 2023 Oct 5.
    2: Patel K, Patel DK. The Potential Therapeutic Properties of Prunetin against Human Health Complications: A Review of Medicinal Importance and Pharmacological Activities. Drug Metab Bioanal Lett. 2022;15(3):166-177. doi: 10.2174/2949681015666220912104743. 25(21):11713. doi: 10.3390/ijms252111713.
    4: Kim B, Jo C, Choi HY, Lee K. Prunetin Relaxed Isolated Rat Aortic Rings by Blocking Calcium Channels. Molecules. 2018 Sep 17;23(9):2372. doi: 10.3390/molecules23092372.

    合成参考文献


    参考文献:10.1186/1475-2891-10-73
    摘要:Bojić M, Debeljak Ž, Tomičić M, Medić-Šarić M, Tomić S. Evaluation of antiaggregatory activity of flavonoid aglycone series. Nutrition Journal. 2011 Jul 11;10(1):73. doi: 10.1186/1475-2891-10-73.
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