📜对羟基苯乙腈置于吡啶,盐酸,Potassium Carbonate,苯体系中,化学反应生成 樱黄素 参考文献:Baker Et Al.,Journal Of The Chemical Society,1953,P. 1852,1856 标题:Baker Et Al.,Journal Of The Chemical Society,1953,P. 1852,1856
专利号:US-10030003-B2 优先权日:2014-09-10 标 题:Synthesis of isoflavanes and intermediates thereof 发明人:BELIAEV NIKOLAI; SHAFRAN YURI 权利人:SYSTEM BIOLOGIE AG 摘要:Subject of the invention is a method for enantioselective production of an isoflavane from an isoflavone, comprising the steps: (a) selectively reducing the isoflavone, such that the 4-keto group of the isoflavone is converted to a 4-hydroxy group, and the 2,3-double bond of the isoflavone is converted to a 2,3-single bond, thereby obtaining a 4-hydroxy intermediate, and (b) reacting the 4-hydroxy intermediate with a chiral reagent, such that a chiral group is covalently attached to the C4-position of the 4-hydroxy intermediate, thereby obtaining a chiral intermediate. The invention also relates to intermediates of formulae (IV), (V), (VI) and (VII) obtainable in the inventive process.
专利号:US-8969596-B2 优先权日:2008-08-14 标题:Synthesis of equol 发明人:STEFFAN BERT 权利人:STEFFAN BERT 摘要:Subject of the invention is a method for the production of isoflavanes from isoflavones, whereby in a first reaction step (a) the 4-keto group of the isoflavone is reduced in a enantioselective manner, whilst the 2,3-double bond is maintained, to the 4-hydroxy compound.
专利号:US-2007232495-A1 优先权日:2006-03-24 标题:Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof 发明人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L 权利人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L 摘要:The invention is related to compositions and methods that naturally protect plant tissues against ultraviolet radiation and temperature, thus giving protection against sunburn to plants, plant parts, fruits and/or flowers during their development. The invention is also related to compositions and methods to naturally improve the color of plants, plant parts, fruits and/or flowers by inducing the natural synthesis of flavonoids and anthocyanins present in plants. Likewise, the present invention is directed to improving the nutritional value of plants, plant parts, fruits and/or flowers by increasing the normal levels of polyphenolic compounds, especially flavonoids, present therein. Additionally, the present invention is related to compositions and methods that give more resistance to plants, plant parts, fruits and/or flowers against pathogens as bacteria and fungi. Finally, the present invention is related to plants, plant parts, fruits, flowers and/or propagating material treated with the compositions described in the present document.
专利号:US-2012094336-A1 优先权日:2008-08-14 标题:Synthesis of equol
专利号:CA-2960437-A1 优先权日:2014-09-10 标 题 :Synthesis of isoflavanes and intermediates thereof
专利号:WO-2006053688-A1 优先权日:2004-11-17 标 题:Cosmetic and dermatological preparations for the treatment of mature skin 发明人:DOERING THOMAS 权利人:HENKEL KGAA; DOERING THOMAS 摘要:The invention relates to topical cosmetic or dermatological compositions for the treatment of mature or intrinsically or extrinsically aged skin, in particular, for anti-wrinkle treatment, containing a combination of at least two selected peptides in a suitable cosmetic or dermatological vehicle, which have an effect at differing points of the process of collagen and/or fibronectin synthesis.
1: Hamed AB, El-Abhar HS, Abdallah DM, Ahmed KA, Abulfadl YS. Prunetin in a GPR30-dependent manner mitigates renal ischemia/reperfusion injury in rats via interrupting indoxyl sulfate/TLR4/TRIF, RIPK1/RIPK3/MLKL, and RIPK3/PGAM5/DRP-1 crosstalk. Saudi Pharm J. 2023 Nov;31(11):101818. doi: 10.1016/j.jsps.2023.101818. Epub 2023 Oct 5. 2: Patel K, Patel DK. The Potential Therapeutic Properties of Prunetin against Human Health Complications: A Review of Medicinal Importance and Pharmacological Activities. Drug Metab Bioanal Lett. 2022;15(3):166-177. doi: 10.2174/2949681015666220912104743. 25(21):11713. doi: 10.3390/ijms252111713. 4: Kim B, Jo C, Choi HY, Lee K. Prunetin Relaxed Isolated Rat Aortic Rings by Blocking Calcium Channels. Molecules. 2018 Sep 17;23(9):2372. doi: 10.3390/molecules23092372.
合成参考文献
参考文献:10.1186/1475-2891-10-73 摘要:Bojić M, Debeljak Ž, Tomičić M, Medić-Šarić M, Tomić S. Evaluation of antiaggregatory activity of flavonoid aglycone series. Nutrition Journal. 2011 Jul 11;10(1):73. doi: 10.1186/1475-2891-10-73.