CAS: 51543-39-6; (S)-2-(2-Fluoro-[1,1'-Biphenyl]-4-yl)Propanoic Acid

上下游产品

(S)-3-O-(2-(2-fluoro-4-biphenyl)propionyl)-1,2-O-isopropylidene-α-D-glucofuranose methyl 2-(2-fluoro-4-biphenylyl)propionate fluorobiprofen methanol 2-(2-fluoro-4'-hydroxy-biphenyl-4-yl)-propionic acid fluorobiprofen (R)-flurbiprofen 5′-(S)-[(2-Fluoro-1,1′-biphenyl-4-yl)propanoyl]-thymidine

(R)-2-氟比洛芬 氟比洛芬 以 乙醇,水 作为反应溶剂,化学反应生成 艾氟洛芬
参考文献:简单羧酸的自发振荡体外手性转化及其可能机理
标题:简单羧酸的自发振荡体外手性转化及其可能机理
摘要:在较早的研究中,我们收集了溶解在70%乙醇水溶液中的简单羧酸的自发振荡体外手性转化的实验证据(主要来自薄层色谱法和旋光法).为了阐明这种现象,我们开发了两个链接模板的简单理论模型.最近,基于缩二脲测试(氨基酸),高效液相色谱和13,我们获得了手性羧酸自发缩合的其他实验证据.13 C NMR光谱(脯氨酸和羟基酸).我们在现有文献的背景下简要描述了我们的实验结果,并概述了针对这些现象的改进的理论模型.我们的系统在某些方面类似于有机硅烷醇的振荡缩合反应.在这里,关键的反应是羧酸衍生的烯醇的形成.最后,我们讨论了简单羧酸的振荡手性转化对于生物化学,药理学和相关生命科学的重要性.版权所有©2010 John Wiley&sons,Ltd.
DOI:10.1002/poc.1739

专利信息

专利号:US-2012029226-A1
优先权日:2009-02-06
标题:Method for the synthesis of chiral alpha-aryl propionic acid derivatives
发明人：KAPTEIN BERNARDUS; VLIEG ELIAS; NOORDUIN WILLEM LIEUWE
权利人:KAPTEIN BERNARDUS; VLIEG ELIAS; NOORDUIN WILLEM LIEUWE
摘要:The present invention provides a method for the synthesis of optically pure α-aryl propionic acid derivatives comprising subjecting the corresponding racemic α-aryl propionic acid derivatives to high sheer or impact forces, such as grinding.

专利号:US-6953678-B1
优先权日:1999-07-26
标题 :Use of orthoesters for the synthesis of chiral acids in biocatalyzed irreversible esterification processes
发明人：MORRONE RAFFAELE; NICOLOSI GIOVANNI; PIATTELLI MARIO
权利人:CONSIGLIO NAZIONALE RICERCHE
摘要:A process for the resolution of enantiomeric mixtures of a chiral carboxylic acid, including an esterification reaction of the carboxylic acid in an organic solvent, in the presence of a stereoselective hydrolase, characterized in that an orthoester of the formula R 1 —C(OR 2 ) 3 , in which R 1 is selected from H and C 1 –C 4 alkyl and R 2 is C 1 –C 8 alkyl or —CH 2 —C 6-10 aryl, is used as the esterification reactive.

专利号:US-8148527-B1
优先权日:2011-01-18
标 题:Resolution of 1-(4-methoxybenzyl)-octahydro-isoquinoline
发明人：DIVI MURALI KRISHNA PRASAD; PENDYALA SRINIVAS RAO; RAMANA LAVU VENKATA
权利人:DIVI MURALI KRISHNA PRASAD; PENDYALA SRINIVAS RAO; RAMANA LAVU VENKATA; DIVIS LAB LTD
摘要:The resolution of racemic 1-(4-methoxybenzyl)-octahydro-isoquinoline, a key intermediate in the synthesis of the antitussive agent dextromethorphan, is reported using (R)-2-(6-methoxy-2-naphthyl) propionic acid in good yields. The resolving agent and the undesired isomer of the octahydro-isoquinoline have been recovered in good yield.

专利号:US-7807837-B2
优先权日:2004-05-07
标 题 :Scalable synthesis of imidazole derivatives
发明人：JONES TODD K; MANI NEELAKANDHA
权利人:JANSSEN PHARMACEUTICA NV
摘要:Imidazole derivatives, compositions containing them, methods of preparing them, including regioselective scale-up synthetic methods, and methods of using them.

专利号:US-7507756-B2
优先权日:2004-05-07
标 题 :Scalable synthesis of imidazole derivatives

专利号:US-2009143591-A1
优先权日:2004-05-07
标 题 :Scalable synthesis of imidazole derivatives