CAS: 4515-23-5; Cbz-L-Aspartic Anhydride

相似化合物

75443-62-8 35739-00-5 143394-93-8

上下游产品

N-Cbz-L-Asp benzyl chloroformate benzyl alcoholN-(N-benzyloxycarbonyl-L-α-aspartyl)-L-valine methyl esterN-(N-benzyloxycarbonyl-L-α-aspartyl)-L-valine methyl ester N-(N-benzyloxycarbonyl-L-β-aspartyl)-L-valine methyl esterN-(N-benzyloxycarbonyl-L-β-aspartyl)-L-valine methyl ester N-(N-benzyloxycarbonyl-L-α-aspartyl)-L-glutamic acid diethyl esterN-(N-benzyloxycarbonyl-L-α-aspartyl)-L-glutamic acid diethyl ester N-(N-benzyloxycarbonyl-L-α-aspartyl)-glycine ethyl esterN-(N-benzyloxycarbonyl-L-α-aspartyl)-glycine ethyl ester

📜N-Cbz-L-天冬氨酸置于乙酸酐体系中,化学反应 15.0H,反应生成 Z-天冬氨酸酸酐
参考文献:苯酚作为前药的氨基酸酯:对乙酰氨基酚的甘氨酸,β-天冬氨酸和α-天冬氨酸酯的合成和稳定性
标题:苯酚作为前药的氨基酸酯:对乙酰氨基酚的甘氨酸,β-天冬氨酸和α-天冬氨酸酯的合成和稳定性
摘要:计算了对乙酰氨基苯酚(i)在25°和μ= 1.0 M下的甘氨酸(II),β-天冬氨酸(iii)和α-天冬氨酸(iv)酯的水解的ph速率分布.酯ii和iii的水解主要通过涉及水,氢氧根离子和各种离子形式底物的分子间反应发生.酯iv的水解主要通过分子内反应发生.甲酸根,乙酸根和磷酸根离子以及氨丁三醇对酯ii降解的催化作用与它们对二氯乙酸乙酯的水解作用相似.在碳酸氢盐缓冲液中酯ii水解的有效催化与涉及二氧化碳以及氨基甲酸酯中间体的形成和分解的机理是一致的.
DOI:10.1002/jps.2600700812

专利信息

专利号:US-4789758-A
优先权日:1985-01-07
标题 :Process for the production of an N-protected-L-α-aspartyl-L-phenylalanine
发明人：TAKEMOTO TADASHI; YUKAWA TOSHIHIDE; HISAMITSU KUNIO
权利人:AJINOMOTO KK
摘要:A process is described for the synthesis of N-protected-L-α-aspartyl-L-phenylalanine by both (a) the rection of an N-protected-L-aspartic anhydride and a R 1 -L-phenylalanine, and (b) the reaction of an N-protected-L-aspartic anhydride and L-phenylalanine in an aqueous medium in the presence of R 2 , where R 1 may be an alkali metal salt, alkaline earth metal salt, ammonium salt or organic amine salt, and R 2 may be an ammonium salt or an alkali or alkaline earth metal salt of an inorganic or organic acid.

专利号:US-2009163697-A1
优先权日:2007-12-20
标 题:Multicomponent coupling and glycopeptide synthesis with cyclic thioanhydrides
发明人：CRICH DAVID; BOWERS ALBERT A
权利人:CRICH DAVID; BOWERS ALBERT A
摘要:Disclosed is a method of coupling an amino or hydroxyl compound with the amino portion of a sulfonamide via condensation with a cyclic thioanhydride. The reaction of cyclic thioanhydrides with amines affords amides functionalized with thioacids, which can be trapped in situ with preferably electron deficient arylsulfonamides. In this manner the cyclic thioanhydride serves as a linchpin in a three component coupling sequence.

专利号:WO-9517418-A2
优先权日:1993-12-22
标 题 :NOVEL INTERMEDIATES FOR THE SYNTHESIS OF L-ASPARTYL-D-α-AMINOALKANOYL-(S)-N-α-ALKYLBENZYL AMIDES USEFUL AS ARTIFICIAL SWEETENERS

专利号:EP-0736037-A1
优先权日:1993-12-22
标题 :NOVEL INTERMEDIATES FOR THE SYNTHESIS OF L-ASPARTYL-D-$g(a)-AMINOALKANOYL-(S)-N-$g(a)-ALKYLBENZYL AMIDES USEFUL AS ARTIFICIAL SWEETENERS

专利号:US-8575276-B2
优先权日:2006-08-04
标 题 :Biomimetic compounds and synthetic methods therefor
发明人：LEE BRUCE P
权利人:LEE BRUCE P; KNC NER ACQUISITION SUB INC
摘要:Synthesis methods for creating polymeric compounds comprising dihydroxyphenyl derivatives (DHPD), or DHPp i.e. polymers modified with DHPD, with desired surface active effects are described. The polymer backbone of DHPp has structural or performance features that can be tailored to control physical properties of DHPp, allowing it to be useful for different applications i.e. tissue adhesives or sealants, adhesion promoting coatings, and antifouling coatings.

专利号:EP-0149582-B1
优先权日:1984-01-19
标 题 :Process for the preparation of aspartyl peptides and derivatives of aspartic acid useful in their synthesis