CAS: 3680-02-2; Methyl Vinyl Sulfone

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1889-59-4 67-71-0 69773-82-6

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1-氯-2-(甲基磺酰基)乙烷置于三乙胺体系中,用68%的收率获得产物甲基乙烯砜
参考文献:丙酮与不饱和化合物在酸性溶液中阴极交叉偶联的反应机理
标题:丙酮与不饱和化合物在酸性溶液中阴极交叉偶联的反应机理
摘要:证实当使用具有自由基可接受的双键并吸附在汞阴极上的化合物时,丙酮与不饱和化合物在硫酸水溶液中的阴极交叉偶联可以顺利进行.从这一事实可以得出结论,耦合是通过将丙酮单电子还原形成的自由基中间体添加到阴极表面上的双键而发生的.由于没有发生丙酮与吸附在阴极上的极性炔属三键化合物的偶联,排除了添加源自丙酮的阴离子中间体的可能性.
DOI:10.1246/bcsj.59.757

专利信息

专利号:US-9388147-B2
优先权日:2009-11-13
标题 :Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
发明人：MARTINBOROUGH ESTHER; BOEHM MARCUS F; YEAGER ADAM RICHARD; TAMIYA JUNKO; HUANG LIMING; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA; TIMONY GREGG ALAN; BROOKS JENNIFER L; PEACH ROBERT; SCOTT FIONA LORRAINE; HANSON MICHAEL ALLEN
权利人:RECEPTOS INC; CELGENE INTERNAT II SÃ RL
摘要:Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds are provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

专利号:US-9394264-B2
优先权日:2009-11-13
标 题:Sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
发明人：MARTINBOROUGH ESTHER; BOEHM MARCUS F; YEAGER ADAM RICHARD; TAMIYA JUNKO; HUANG LIMING; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA
权利人:RECEPTOS INC
摘要:Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds are provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

专利号:US-4490374-A
优先权日:1982-09-30
标 题:5,6-Dialkoxy-3,4-optionally substituted-2(1H)quinazolinones, composition and method of use
发明人：BANDURCO VICTOR T; LEVINE SEYMOUR D; MULVEY DENNIS M; TOBIA ALFONSO J
权利人:ORTHO PHARMA CORP
摘要:The synthesis of substituted quinazolinones is described. The novel quinazolinones are renal vasodilators and thereby increase renal blood flow, and are useful as cardiovascular agents.

专利号:US-2005130228-A1
优先权日:2000-03-17
标题:Dosing form for a polymer support, use of said dosing form in organic chemical synthesis and method for production of said dosing form
发明人：RUHLAND THOMAS; HOLM PER; SCHULTZ KIRSTEN; HOLM JANNIE E; ANDERSEN KIM
权利人:LUNDBECK & CO AS H
摘要:A dosing form for a polymer support for organic chemical synthesis in a solvent medium comprising a fixed weight amount of beads of a polymer containing functional groups, which polymer is insoluble in the solvent for the intended synthesis, is provided as compressed tablets of essentially equal weight and composition wherein the polymer beads are essentially intact and are released as such when the tablets are disintegrated in said solvent. Use of the dosing form is made in conventional synthesis, in parallel synthesis, in split and mix synthesis and/or combinatorial chemistry. In a method for producing the dosing form, beads of a polymer having functional gropusgroups is compressed into tablets after pre-treatment with an aprotic organic solvent. groups are compressed into tablets after pre-treatment with an aprotic organic solvent.

专利号:US-2003134303-A1
优先权日:2001-12-11
标 题:Adenine nucleotide-binding protein-directed probes, and methods of their synthesis and use
发明人：CAMPBELL DAVID A; WASH PAUL
权利人:ACTIVX BIOSCIENCES INC
摘要:The invention relates to compositions and methods for the synthesis and use of Adenosine nucleotide binding protein-directed affinity labels. Adenosine nucleotide binding proteins may be labeled with probes comprising adenosine, or an analogue thereof, functionalized at the 5′ position with reactive group capable of reacting with an amino acid side chain functionality at an adenosine nucleotide binding site, and at the 2′ or 3′ position with a TAG for sequestering and/or identifying the resulting conjugate. The probes may be used for determining the presence or amount of one or more adenosine nucleotide binding proteins in a complex mixture, particularly a cellular mixture, for screening for drugs, and other purposes associated with the presence of the adenine nucleotide-binding protein(s) in a cell or changes in the presence, amount, activity, or relative concentration of the active adenosine nucleotide-binding protein.

专利号:US-8507538-B2
优先权日:2009-11-13
标 题:Selective heterocyclic sphingosine 1 phosphate receptor modulators
发明人：BOEHM MARCUS F; MARTINBOROUGH ESTHER; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; YEAGER ADAM RICHARD
权利人:BOEHM MARCUS F; MARTINBOROUGH ESTHER; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; YEAGER ADAM RICHARD; RECEPTOS INC
摘要:Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds is provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.