CAS: 2436-29-5; 3-(1,3-Dioxoisoindolin-2-yl)Propanal

上下游产品

1,3-二氢-1,3-二氧代-2H-异吲哚-2-丙酰氯 3-Phthalimidopropionyl Chloride 17137-11-0
3-(N-苯二甲酰亚氨基)丙酸 3-Phthalimidopropanoic Acid 3339-73-9
N-(3-羟丙基)酞亚胺 N-(3-Hydroxypropyl)Phthalimide 883-44-3
N-(4-烯丁基)邻苯二甲酰亚胺 1-Phthalimido-3-Butene 52898-32-5
N-(3-溴丙基)苯二胺 2-(3-Bromopropyl)Isoindole-1,3-Dione 5460-29-7
2-(4-羟基丁基)-1H-异吲哚-1,3(2H)-二酮 N-(4-Hydroxybutyl)Phthalimide 24697-70-9
2-(4-甲基戊-3-烯基)异吲哚-1,3-二酮 2-(4-Methylpent-3-En-1-yl)Isoindoline-1,3-Dione 13296-42-9
2-(3,3-Dimethoxypropyl)Isoindoline-1,3-Dione 166104-00-3 N-Propargylphthalimide 7223-50-9 3-Phthalimido-1-Propene 01/09/5428

N-(3-溴丙基)苯二胺置于盐酸,水,双(三甲基硅烷基)氨基钾体系中,用 四氢呋喃,N,N-二甲基乙酰胺,N,N-二甲基甲酰胺 用作溶剂,化学反应 25.75H,反应生成3-邻苯二甲酰亚胺丙醛
参考文献:将砜转化为硝基和醛的协议
标题:将砜转化为硝基和醛的协议
摘要:已经开发了一种将砜转化为硝酮并因此转化为相应的羰基衍生物的简单方法.一些例子表明,这是砜工具箱中一种可靠且用途广泛的新型反应,具有巨大的合成潜力.核磁共振和计算研究用于阐明机理.
Doi:10.1021/acs.Orglett.8B02483

专利信息

专利号:US-2005119332-A1
优先权日:1998-03-12
标 题 :Substituted thiophene compounds as modulators of protein tyrosine phosphatases (PTPases)
发明人：JEPPESEN LONE; ANDERSEN HENRIK S; OLSEN OLE H; JUDGE LUKE M; HOLSWORTH DANIEL D; BAKIR FARID; AXE FRANK U; GE YU
摘要:The present invention provides novel compounds of formula 1a, n nnovel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

专利号:WO-9946244-A1
优先权日:1998-03-12
标题 :Modulators of protein tyrosine phosphatases (ptpases)
发明人：JEPPESEN LONE; ANDERSEN HENRIK SUNE; OLSEN OLE HVILSTED; JUDGE LUKE MILBURN; HOLSWORTH DANIEL DALE; BAKIR FARID; AXE FRANK URBAN; GE YU
权利人:NOVO NORDISK AS; ONTOGEN CORP
摘要:The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

专利号:US-2002165398-A1
优先权日:1998-03-12
标题:Modulators of protein tyrosine phosphatases (PTPases)
发明人：JEPPESEN LONE; ANDERSEN HENRIK SUNE; OLSEN OLE HVILSTED; JUDGE LUKE MILBURN; HOLSWORTH DANIEL DALE; BAKIR FARID; AXE FRANK URBAN; GE YU
摘要:The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. n The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimers disease and schizophrenia, and infectious diseases.

专利号:EP-1062204-A1
优先权日:1998-03-12
标题 :Modulators of protein tyrosine phosphatases (ptpases)
发明人：JEPPESEN LONE; ANDERSEN HENRIK SUNE; OLSEN OLE HVILSTED; JUDGE LUKE MILBURN; HOLSWORTH DANIEL DALE; BAKIR FARID; AXE FRANK URBAN; GE YU
权利人:NOVO NORDISK AS; ONTOGEN CORP
摘要:The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

专利号:US-2003096374-A1
优先权日:1999-01-27
标题:Synthesis of oligoketides

专利号:US-4831159-A
优先权日:1986-06-20
标题 :Process for hydroformylation of n-vinyl-2-pyrrolidinone
发明人：LIN JIANG-JEN
权利人:TEXACO INC
摘要:A process is disclosed for preparing isomeric aldehydes by contacting N-vinyl-2-pyrrolidinone and synthesis gas in the presence of a rhodium-containing compound with or without additional phosphine ligand and a solvent. The alpha and beta isomeric aldehydes such as 2-N-(2-pyrrolionyl)propanaldehyde and 3-N-(2-pyrrolidonyl)propanaldehyde can be converted to 1,2- or 1,3-diaminopropanes via reductive amination or to alcohol amines via reduction.