CAS: 2304-80-5; Octadecanamide, N-[(1S,2R)-2-Hydroxy-1-(Hydroxymethyl)Heptadecyl]-

上下游产品

Ethyl (2R,3R)-2-Octadecanoylamino-3-Hydroxyoctadecanoate 1018676-90-8

📜Ethyl (2R,3R)-2-octadecanoylamino-3-Hydroxyoctadecanoate置于sodium Tetrahydroborate体系中,用 乙醇 用作溶剂,化学反应 48.0H,以87%的收率获得二羟基神经酰胺
参考文献:Process For Producing Optically Active Beta-Hydroxy-Alpha-Aminocarboxylic Acid Ester
标题:Process For Producing Optically Active Beta-Hydroxy-Alpha-Aminocarboxylic Acid Ester
摘要:本发明的目的是高效,简单,具有工业优势地生产光学活性β-羟基-α-氨基羧酸酯的反式形式.该目的可以通过使用光学活性胺络合物作为催化剂,通过不对称还原β-酮基-α-氨基羧酸酯直接和选择性地生产光学活性β-羟基-α-氨基羧酸酯的反式形式来实现.此外,将甘氨酸衍生物与羧酸衍生物反应可以高产率地生产β-酮基-α-氨基羧酸酯作为原料.

专利信息

专利号:US-11612556-B2
优先权日:2014-12-16
标 题:Peptidic compounds, compositions comprising them and uses of said compounds, in particular cosmetic uses
发明人：PESCHARD OLIVIER; DOUCET ANNE; LEROUX RICHARD; MONDON PHILIPPE
权利人:SEDERMA SA
摘要:The peptidic compound comprises at least an aminoacid which is lysine, ornithine, diaminopropionic acid or diaminobutyric acid or a derivative of these aminoacids, on which a carboxylic acid is grafted via a peptidic bound on the nitrogen of the lateral chain, said carboxylic acid comprising a (poly)cycle or (poly)heterocycle. Preferably, the grafted carboxylic acid is an aminoacid or a derivative, in particular selected from, a proline, a hydroxyproline or pyroglutamic acid.The peptidic compound can stimulate the synthesis of the main molecules constituting the extracellular matrix of the skin, especially collagen 1 and 4 and elastin. It can be used for topical cosmetic treatment such as a global anti-aging treatment, or for specific activities, including anti-wrinkles, moisturizing, to improve the mechanical properties of the skin, firmness/tone/elasticity/flexibility, to increase density and volume of the skin, improve skin radiance, for a restructuring effect and/or to fight stretch marks.

专利号:WO-2024109867-A1
优先权日:2022-11-25
标 题:Vegetable oil ceramides, synthesis method therefor, and use thereof
发明人：YANG CHAOWEN; YE LIU; LI QING
权利人:SHENZHEN DIKEMAN BIOTECHNOLOGY CO LTD
摘要:The present invention belongs to the technical field of biological medicines. Disclosed are vegetable oil ceramides. The vegetable oil ceramides are obtained by reacting vegetable oil fatty acids with sphingosine compounds, the sphingosine compounds being selected from sphingosine, phytosphingosine and dihydrosphingosine, and the vegetable oil fatty acids being selected from olive oil fatty acids, tea oil fatty acids, sea buckthorn oil fatty acids, grape seed oil fatty acids, nut oil fatty acids, borage oil fatty acids, rose hip oil fatty acids, bean oil fatty acids, rice bran oil fatty acids, etc. Further disclosed in the present solution are a synthesis method for and the use of the vegetable oil ceramides. The vegetable oil ceramides exert excellent performance in areas of repairing natural skin barriers, anti-inflammation, tissue healing, aging resistance, etc., and have extensive application prospects in the fields of cosmetics, health-care products, biological medicines, etc.

专利号:US-11529370-B2
优先权日:2017-11-24
标 题 :Use of composition comprising stem cell-derived exosome as effective ingredient in strengthening skin barrier and improving skin barrier function
发明人：YI YONG WEON; CHO BYONG SEUNG
权利人:EXOCOBIO INC
摘要:A composition for strengthening skin barrier or improving skin barrier function is able to improve objective indicators related to the protection of skin barrier, the strengthening of skin barrier, and/or the improvement of skin barrier function. The composition exhibits the effects of increasing the amount of ceramides, dihydroceramides and sphingoid bases, increasing the activities of enzymes that are involved in the synthesis thereof, and decreasing the activities of enzymes that are involved in the degradation thereof. In addition, the composition is able to restore skin barrier function by reducing TSLP, IL-4, and IL-13 which are closely associated with skin barrier damage, and thus interrupting a vicious circle in which the lipids and proteins contributing to skin barrier decrease.

专利号:US-2022298103-A1
优先权日:2014-12-08
标 题 :Anti-fungals targeting the synthesis of fungal shingolipids

专利号:US-2022125838-A1
优先权日:2019-02-11
标题 :Immunomodulatory glycosphingolipids and methods of use thereof
发明人：OH SUNGWHAN; KASPER DENNIS L; SONG HEEBUM; PARK SEUNG BUM
权利人:HARVARD COLLEGE; SEOUL NAT UNIV R&DB FOUNDATION
摘要:Provided herein are a subset of alpha-galactosylceramide (alpha-GC) compounds having improved immunomodulatory activity, particularly with respect to NKT cell number and activity. Also provided herein are methods of use of such compounds, including in the modulation of NKT cells and/or activity in vivo. Further provided are combinatorial synthesis methods for generating alpha-GC compounds of specifically defined structure and thereby generating pure preparations thereof.

专利号:EP-3230259-B1
优先权日:2014-12-08
标 题 :Anti-fungals targeting the synthesis of fungal shingolipids