CAS: 225920-04-7; (R)-1-(4-Ethoxyphenyl)Ethan-1-Ol

该化合物是一种手性二次酒精,带有代用乙氧基替代芳香环,其立体特性(R)配置使其成为非对称合成中有价值的中间体,特别是对于需要对应选择性精确度的药品和精细化学品而言.乙氧基混合物会增加有机溶剂的溶解性,促进其用于混合反应或作为手性辅助剂的前体.该化合物定义明确的立体化学能确保合成路线的高度再生性,而在标准条件下,其稳定性允许直接处理和储存.其效用扩大到催化氢化或氧化过程,作为生物活性分子的建筑块.纯度和光学活动通常由手动HPLC或极地测量进行验证.

英文名称(R)-1-(4-Ethoxyphenyl)Ethan-1-Ol
中文名称(R)-1-(4-乙氧基苯基)乙-1-醇
IUPAC名称(R)-1-(4-ethoxyphenyl)ethan-1-ol
其它别名(R)-1-(4-乙氧基苯基)乙醇; (R)-1-(4-Ethoxyophenyl)Ethanol
CAS编号225920-04-7
MFCD编号:MFCD09863704
EINECS号:970-328-5
分子式:C10H14O2
分子量:166.22
产品CID: 1164050
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: GKGQWBJLOYXULB-MRVPVSSYSA-N
InChI=1S/C10H14O2/c1-3-12-10-6-4-9(5-7-10)8(2)11/h4-8,11H,3H2,1-2H3/t8-/m1/s1…
计算化学: 氢键受体数2.0氢键供体数1.0可旋转键数3.0

MSDS等安全信息

危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
警示词Warning
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

欧盟法规

C&L通报

上下游产品

4'-ethoxyacetophenone methylmagnesium bromide 4-ethoxybenzaldehyde 4-ethoxystyrene (S)-(-)-1-(4-ethoxyphenyl)ethyl acetate 1-(4-ethoxyphenyl)ethylamine methyl 4-ethoxybenzoate

合成工艺路线路线简述

(R)-1-(4-Ethoxyphenyl)Ethyl Acetate置于immobilized Calb Lipase,氨体系中,用异丙醚用作溶剂,化学反应 12.0H,反应生成(R)-4-乙氧基-α-甲基苯乙醇
参考文献:A Tandem And Fully Enzymatic Procedure For The Green Resolution Of Chiral Alcohols: Acylation And Deacylation In Non-Aqueous Media
标题:A Tandem And Fully Enzymatic Procedure For The Green Resolution Of Chiral Alcohols: Acylation And Deacylation In Non-Aqueous Media
摘要:A Green And Fully Enzymatic Procedure For The Resolution Of Chiral Alcohols Through Lipase/esterase-Catalyzed Acylation And Subsequent Lipase-Catalyzed Aminolysis Using Anhydrous Ammonia Was Demonstrated. Both Enantiomers Can Be Obtained In High Ee Values (Up To >99%) Under Ambient Reaction Conditions. The Solvent And Acyl Donors Can Be Recycled,And The Enzyme Can Be Reused For Up To Five Times. (C) 2011 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Tetasy.2011.05.022