CAS: 2010-15-3; 3-Phenyl-2-Thioxoimidazolidin-4-One

该化合物是一种七环化合物,其内含一个含有苯替代成分和硫碳基功能组的聚氨二醇基芯,具有独特的反应性,使其成为有机合成中有价值的中间体,特别是用于研制药品和农用化学品; 氟二氮基的出现增强了其在核循环和电益反应中的效用,有助于建立复杂的分子框架; 其温和条件下的稳定性和与多种反应条件的兼容性进一步凸显了其多功能性; 研究人员支持该化合物在药用化学中的潜力,在其中作为针对各种治疗途径的生物活性分子的辅助器.

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上下游产品

CAS号5680-79-5 甘氨酸甲酯盐酸盐 | CAS号103-72-0 异硫氰酸苯酯 | CAS号701-73-5 METHYL DITHI°CA... | CAS号623-33-6 甘氨酸乙酯盐酸盐 | CAS号56-40-6 甘氨酸 | CAS号2215-20-5 苯异硫脲基乙酸 | CAS号104892-41-3 ethyl 2-(phenyl... | CAS号616-34-2 甘胺酸甲酯 | CAS号7164-98-9 1-苯基咪唑 | CAS号32832-07-8 5-benzylidene-3... | CAS号82754-77-6 5-amino-1-oxo-2... | CAS号2221-13-8 3-苯基咪唑烷-2,4-二酮 | CAS号2211-33-8 1-苯基咪唑啉-2,4,5-三酮 | CAS号6437-09-8 1-phenyl-3H-imi...

合成工艺路线路线简述

    📜2-氨基-N-苯基乙酰胺置于乙醇,水,Mercury Dichloride体系中,化学反应生成苯基乙内酰脲-甘氨酸
    参考文献:Johnson; Hill; Kelsey,Journal Of The American Chemical Society,1920,Vol. 42,P. 1714,1719
    标题:Johnson; Hill; Kelsey,Journal Of The American Chemical Society,1920,Vol. 42,P. 1714,1719

    海关参考信息

    专利信息


    专利号:US-3943142-A
    优先权日:1969-01-24
    标 题:Dye intermediates and their preparation and use in the synthesis of methine dyes
    发明人:OWEN JOHN R
    权利人:EASTMAN KODAK CO
    摘要:Compositions of matter are provided comprising a stable, non-vaporous monomeric methylene base selected from a 2-methylenethiazoline; a 2-methylenebenzothiazoline; a 2-methylenenaphthothiazoline; a 2-methylenebenzoselenazoline; and a 2-methylenenaphthoselenazoline. The compositions of the invention are prepared by reacting the parent 2-methyl quaternary salt with a non-hydroxylic base which removes a proton of the heterocyclic salt together with a proton acceptor which inhibits build-up of the hydro salt of the non-hydroxylic base, the reaction being conducted under anhydrous conditions in a non-hydroxylic liquid in which the heterocyclic quaternary salt is sufficiently insoluble to inhibit dimer formation. The compositions of the invention are employed in the preparation of methine dyes.

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    ✅ COA系统入驻 | 共享模式

    主要参考文献

    参考标题:One-Pot Synthesis, Theoretical Study And Antimicrobial Activity Of 5,5′-(1,4-Phenylenebis-(Methanylylidene))Bis(3-Aryl(Alkyl)-2-Thioxoimidazolidin-4-One) Derivatives
    作者:Raafat M. Shaker,Hisham A. Abd El-Naby,Essam Kh. Ahmed,Mahmoud A. A. Ibrahim,Sageda A. Gedamy |发布日期:2019.2.1
    摘要:Abstract A Simple, Facile, And Convenient Practical Method For The One-Pot Synthesis Of Pharmaceutically Interesting 5,5`-(1,4-Phenylenebis-(Methanylylidene))Bis-Thiohydantoins Via A Three-Component Condensation Reaction Of Terephthalaldehyde, α-Amino Acids And Isothiocyanates Had Been Developed. The S-Alkylated Derivatives 6A And 6B Were Obtained By The Alkylation Of The Bis-Thiohydantoins 4A With

    合成参考文献


    摘要:National Technical Information Service., AD691-490
    参考文献:10.1016/0020-711x(80)90268-2
    摘要:Clark RC, Dijkstra J. Chemical modification of phosvitin: Preparation of dimethylaminovitin and methylmercaptovitin and their utility for elucidation of phosvitin primary structure. International Journal of Biochemistry. 1980 Jan;11(6):577–85. doi: 10.1016/0020-711x(80)90268-2.
    参考文献:10.1021/tx000247+
    摘要:Rydberg P, Lüning B, Wachtmeister CA, Eriksson L, Törnqvist M. Applicability of a modified Edman procedure for measurement of protein adducts: mechanisms of formation and degradation of phenylthiohydantoins. Chem Res Toxicol. 2002 Apr;15(4):570–81. doi: 10.1021/tx000247+.
    参考文献:10.1073/pnas.1106383108
    摘要:Evans MJ, Smith-Jones PM, Wongvipat J, Navarro V, Kim S, Bander NH, Larson SM, Sawyers CL. Noninvasive measurement of androgen receptor signaling with a positron-emitting radiopharmaceutical that targets prostate-specific membrane antigen. Proc Natl Acad Sci U S A. 2011 Jun 07;108(23):9578–82.
    参考文献:10.1056/nejmc1212940
    摘要:Berruti A, Generali D, Tampellini M. Enzalutamide in prostate cancer after chemotherapy. N Engl J Med. 2012 Dec 20;367(25):2448; author reply 2448–9. doi: 10.1056/nejmc1212940.
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