CAS: 1641-17-4; (2-Hydroxy-4-Methoxyphenyl)(P-Tolyl)Methanone

该化合物其结构特征为:其结构具有苯并苯的脊椎,具有氢氧基,甲氧基(OCH3)和甲基(-CH3)的替代成分,在室温中通常是一种固体,以其紫外线吸收特性而著称,使其在各种应用中有用,特别是在制成防紫外线辐射的防晒霜和化妆品方面.氢氧基组的存在有助于其在有机溶剂中的溶解性,而甲基组和甲基组则影响其化学再活性和稳定性.此外,该化合物可能具有抗氧化性特性,有助于防止制剂中的氧化性损害.应参考安全数据,以便处理和接触准则,如任何化学物质一样,用于处理和接触.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

2-羟基-4-甲氧基苯甲醛 2-Hydroxy-4-Methoxybenzaldehyde 673-22-3

合成工艺路线路线简述

  • 合成目标产物 2-Hydroxy-4-Methoxy-4'-Methylbenzophenone 主要起始原料 P-Toluoyl Chloride And 1,3-Dimethoxybenzene
  • (文献来源)合成步骤主要原料 P-Toluoyl Chloride 和 1,3-Dimethoxybenzene
4-Methylbenzoic Acid 3-Methoxyphenyl Ester置于lewis Acid体系中,用 硝基苯 用作溶剂,化学反应生成美克西酮
参考文献:Infrared Study Of Polysubstitution Effects In Benzophenones And Acetophenones: Contribution Of Inter And Intracycle Interaction Mechanism
标题:Infrared Study Of Polysubstitution Effects In Benzophenones And Acetophenones: Contribution Of Inter And Intracycle Interaction Mechanism
摘要:
Doi:10.1016/0584-8539(81)80141-9

海关参考信息

专利信息


专利号:US-2010137421-A1
优先权日:2006-11-08
标题 :Small molecule therapeutics, synthesis of analogues and derivatives and methods of use
发明人:THEODORAKIS EMMANUEL; BATOVA AYSE
权利人:THEODORAKIS EMMANUEL; BATOVA AYSE
摘要:Provided herein are compounds that are inducers of apoptosis activators of caspases and pharmaceutically acceptable derivatives thereof. Also provided are methods of synthesis of the compounds and methods for treatment of diseases in which there is uncontrolled cell growth and spread of abnormal cells, such as cancers, by administering the compounds.

专利号:US-10799441-B2
优先权日:2011-06-06
标题:Skin treatments containing pyrroloquinoline quinone (PQQ) esters and methods of preparation and use thereof
发明人:LEWIS II JOSEPH ABERNATHY; DINARDO JOSEPH C
权利人:LEWIS II JOSEPH ABERNATHY; DINARDO JOSEPH C; PCR TECH HOLDINGS LC
摘要:The present invention relates to cosmetic or dermatological compositions containing PQQ or its esters, methods of treating or promoting skin changes by topical application of these compositions, and methods of synthesis of PQQ esters. The PQQ ester-containing compositions of the present invention are unexpectedly effective in treating skin, particularly with respect to skin tolerance. When included in a topical composition, the PQQ esters of the present invention have an antioxidant effect that is useful in treating a skin change.

专利号:US-7825268-B2
优先权日:2003-12-23
标 题:Alkoxylactones, alkoxylactams and alkoxythiolactams for controlling processes based on microbial interaction
发明人:STUMPE STEFAN; BREVES ROLAND; HUCHEL URSULA; JANSSEN FRANK; HAETZELT ANDRE
权利人:HENKEL AG & CO KGAA
摘要:Compounds of the Formula I, n nwherein A 1 is O or NH; A 2 is O or S; each of R 1 and R 2 is independently hydrogen, a methyl or C 2 -C 8 -saturated or mono- or doubly unsaturated, branched or linear hydrocarbon group; and R 3 is a C 1 -C 18 -saturated or mono- or doubly unsaturated, branched or linear hydrocarbon group wherein, each of R 1 , R 2 and R 3 comprises a heteroatom selected from the group consisting of O and S in the chain and/or is mono- or multiply-substituted by a substituent selected from the group consisting of halogen, hydroxy, C 1 -C 6 -alkyl, trifluoromethyl, C 1 -C 6 -alkoxy, C 6 -C 10 -aryl, and C 1 -C 6 -alkyl-C 6 -C 10 -aryl are useful for controlling the interaction process between microorganisms such as in the development and/or maturation of biofilms; multicellular swarm behavior; the concerted development of antibiotic resistances; the concerted synthesis of antibiotics; the concerted synthesis of pigments; the concerted production of extracellular enzymes; or the concerted production of virulence factors.

专利号:EP-1406599-B1
优先权日:2001-07-07
标 题 :Cosmetic and dermatological preparations containing creatine for treating and actively preventing dry skin and other negative alterations of the physiological homeostasis of healthy skin
发明人:SAUERMANN GERHARD; SCHREINER VOLKER; DOERING THOMAS; SIEFKEN WILFRIED; GATERMAN CORNELIA; CARSTENSEN STEFANIE; BIERGIESSER HELGA; BLATT THOMAS
权利人:BEIERSDORF AG
摘要:Topical compositions containing creatine and its precursors and derivatives, are used to improve skin condition and to treat or prevent skin disorders, abnormal lipid peroxidation, reduced cell-cell communication, deficient intracellular DNA synthesis, DNA damage, deficient DNA repair, abnormal post-translational modification of connective tissue components and dandruff. Topical compositions comprising creatine and its precursors and derivatives and optionally electrolytes, polyols, urea and osmolytes are used: (1) to treat or prevent dry skin, to enhance the barrier function of the skin, for treatment, care and prophylaxis of sensitive skin and/or for treatment and prophylaxis of symptoms of a negative change in the physiological homeostasis of normal skin; (2) to treat or prevent inflammatory skin conditions, atopic eczema, polymorphic photodermatitis, psoriasis, vitiligo and sensitive, itching or irritated skin; (3) to treat or prevent abnormal lipid peroxidation; (4) to treat or prevent abnormal ceramide, lipid and energy metabolism of the skin, abnormal transepidermal water loss, reduced skin hydration and moisture content and altered Natural Moisturizing Factor content; (5) to treat or prevent reduced cell-cell communication, deficient intracellular DNA synthesis, DNA damage, reduced endogenous DNA repair, activation of metalloproteinases and/or other proteases or inhibition of corresponding DNA repair mechanisms and abnormal post-translational modification of connective tissue components; (6) to treat or prevent abnormal skin hyaluronic acid and glucosaminoglycan content; and (7) to treat or prevent dandruff of the hair and scalp and skin aging.

专利号:US-2007243147-A1
优先权日:2004-07-24
标 题:Skin and/or Hair Composition Containing Compounds for Increasing The Tanning of Skin
发明人:WOLBER RAINER; TOM DIECK KAREN; SCHERNER CATHRIN; SCHLENZ KATHRIN; KRUSE INGE
权利人:BEIERSDORF AG
摘要:The invention relates to agents that are to be applied to the skin or hair and contain compounds for intensifying tanning of the skin and increasing melanin synthesis in skin or hair. The invention particularly relates to cosmetic or dermatological preparations. Using said preparations results in inducing and intensifying the tanning mechanisms of the skin, intensifying the hair color, and thus also increasing intrinsic protection of the skin or hair.

专利号:US-2020123103-A1
优先权日:2017-05-12
标 题 :Method for the synthesis of an n-acyl compound without the use of organic solvent or acid chloride
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主要参考文献

1. Torres V, Correia T. Contact and photocontact allergy to oxybenzone and mexenone. Contact Dermatitis. 1991 Aug;25(2):126-7. doi: 10.1111/j.1600-0536.1991.tb01802.x. 29(2):70-3. doi: 10.1111/j.1600-0536.1993.tb03485.x.

合成参考文献


摘要:Sigma-Aldrich; Product Search. 2-Hydroxy-4-methoxy-4'-methylbenzophenone (1641-17-4). Available from, as of Dec 11, 2018:
摘要:
摘要:Rodriguez E et al; Photodermatol Photoimmunol Photomed 22 (4): 189-92 (2006)
摘要:English JS et al; Contact Dermatitis 17 (3): 159-62 (1987)
摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118
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