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CAS号13679-75-9 1-(2-噻吩基)-1-丙酮 | CAS号188290-36-0 Thiophene(SIV) | CAS号106-94-5 溴代丙烷 | CAS号20849-87-0 2-(2-propenyl)t... | CAS号15022-18-1 1-(噻吩-2-基)丙-2-酮 | CAS号3437-95-4 2-碘噻吩 | CAS号96-43-5 2-氯噻吩 | CAS号111-65-9 正辛烷 | CAS号142-82-5 正庚烷 | CAS号35250-76-1 5-丙基-噻吩-2-甲醛 | CAS号527-72-0 2-噻吩甲酸 | CAS号188290-36-0 Thiophene(SIV) | CAS号1518-75-8 3-丙基噻吩 | CAS号893735-21-2 1-{5-[4-(Triflu... | CAS号1127217-52-0 2-(4-(trifluoro... | CAS号63068-73-5 5-丙基-2-噻吩羧酸 | CAS号54411-07-3 2,5-二丙基噻吩合成工艺路线路线简述
- 合成目标产物 2-N-Propylthiophene 主要起始原料 1-(2-Thienyl)-1-Propanone
- (文献来源)合成步骤主要原料 1-(2-Thienyl)-1-Propanone
2-噻吩基丙酮置于sodium Hydroxide,一水合肼,乙二醇体系中,化学反应生成2-丙基噻吩
参考文献:Novak Et Al.,Collection Of Czechoslovak Chemical Communications,1957,Vol. 22,P. 1836,1845
标题:Novak Et Al.,Collection Of Czechoslovak Chemical Communications,1957,Vol. 22,P. 1836,1845
专利信息
专利号:US-2008086013-A1
优先权日:2006-06-15
标 题:Carbometallation of alkynes and improved synthesis of uniquinones
发明人:LIPSHUTZ BRUCE H
权利人:UNIV CALIFORNIA
摘要:Methods for the carbometallation of alkynes are presented. Those are useful for the synthesis of CoQ 10 and other ubiquinones as well as for the synthesis of ubiquinol analogs.
专利号:US-8476441-B2
优先权日:2009-01-29
标 题 :Intermediates in the enantioselective synthesis of 3-(aminomethyl)-5-methyl-hexanoic acid
发明人:CONNON STEPHEN JOSEPH; PESCHIULLI ALDO; MARKEY LYN
权利人:CONNON STEPHEN JOSEPH; PESCHIULLI ALDO; MARKEY LYN; TRINITY COLLEGE DUBLIN
摘要:(S)-(+)-3-(aminomethyl)-5-methyl-hexanoic acid or (S)-pregabalin is an anticonvulsive drug. In addition to its use as an anticonvulsive agent, pregabalin has also been indicated as a medicament in the treatment of anxiety, neuropathic pain and pain in patients with fibromyalgia. Provided herein are thioester intermediates in the synthesis of and processes for the synthesis of 3-(aminomethyl)-5-methyl-hexanoic acid in the (R) or (S) configuration.
专利号:US-6800785-B1
优先权日:2002-10-15
标题:Process for the synthesis of estrogen receptor modulators
发明人:MENG DONGFANG
权利人:MERCK & CO INC
摘要:The present invention relates to processes for the synthesis of intermediates useful for the synthesis of estrogen receptor modulators. The process includes new methods for annelating 5-, 6- and 7-membered cycloalkenones onto an indanone.
专利号:US-7173059-B2
优先权日:2003-05-08
标题:Intermediates useful in the synthesis of HIV-protease inhibitors and methods for preparing the same
发明人:ALBIZATI KIM FRANCIS; BABU SRINIVASAN
权利人:AGOURON PHARMA
摘要:Optically active 3-amino-butene and 1,2-dihydroxy-3-amino-butane intermediate compounds, useful in the synthesis of HIV-protease inhibitors and methods of preparing these intermediate compounds are disclosed.
专利号:US-6472534-B2
优先权日:1999-10-21
标 题:Methods for the preparation of intermediates in the synthesis of HIV-protease inhibitors
发明人:BORER BENNETT C; ZOOK SCOTT E; BUSSE JULIETTE K
权利人:AGOURON PHARMA
摘要:Methods for the preparation of chemical intermediates in the synthesis of HIV-protease inhibitors related to and including nelfinavir mesylate are disclosed. The method of this invention comprises converting tetrohydran derivatives into oxazolines to provide key reaction intermediates for the preparation of nelfinavir. Also disclosed is a method for the preparation of a chiral amino alcohol from an epoxy-tetrahydrofuran.
专利号:US-7754646-B2
优先权日:2001-06-29
标 题 :Synthesis and use of organosilica particles
发明人:TRAU MATHIAS; JOHNSTON ANGUS
权利人:NANOMICS BIOSYSTEMS PTY LTD
摘要:Highly functionalized, porous organosilica particles and methods of their synthesis are described that employ high amounts of functional silane such as 3-mercaptopropyl trimethoxysilane. Silane particle diameters are controlled from less than 1 μm to over 100 μm. The particles have a high surface area due to their advantageous internal structures, which consist of large pores, typically up to 10 μm that are linked by small channels of typically about 20 nm diameter. Isothiocyanate modified fluorescent dyes can enter and react with thiol groups inside the pores. The invention also provides clear silica shells of controlled thicknesses to protect fluorescent signals and provide an independent parameter for distinguishing particle types based on light scattering off different sized particles. The particles are stable and useful for many purposes, particularly for optical bar coding in combinatorial synthesis of polymers such as nucleic acid, polypeptide, and other synthesized molecules.