CAS: 153556-42-4; 4-Bromo-3-Fluorobenzoic Acid

相似化合物

133059-43-5 133059-44-6 222978-01-0

上下游产品

CAS号452-74-4 3-氟-4-溴甲苯 | CAS号222978-26-9 2-fluoro-4-[hyd... | CAS号222978-04-3 2-fluoro-4-(imi... | CAS号849758-12-9 4-溴-3-氟苯甲酸甲酯 | CAS号57848-46-1 4-溴-2-氟苯甲醛 | CAS号695188-21-7 4-溴-3-氟苯甲酰氯 | CAS号1020717-99-0 4-溴-5-氟-2-硝基苯甲酸 | CAS号101048-76-4 3-氟-4-氰基苯甲醛 | CAS号343564-56-7 4-溴-3-氟-N-甲氧基-N-甲基苯胺 | CAS号304445-49-6 3-氟-4-溴-苯乙酮 | CAS号222978-03-2 4-氰基-3-氟苄溴

4-溴-3-氟甲苯置于吡啶,Potassium Permanganate体系中,用88%的收率获得4-溴-3-氟苯甲酸
参考文献:双蛋白法呢基转移酶-香叶基香叶基转移酶-I抑制剂可作为潜在的癌症化学治疗剂.
标题:双蛋白法呢基转移酶-香叶基香叶基转移酶-I抑制剂可作为潜在的癌症化学治疗剂.
摘要:一系列新的二芳基醚内酰胺已被确定为非常有效的蛋白法呢基转移酶(ftase)和蛋白geranylgeranyltransferase I(ggtase-I)的双重抑制剂,这些酶涉及ras的烯丙基化.这些化合物之一与ftase之间形成的配合物的结构已通过x射线晶体学确定.这些化合物是第一个被报道在体内抑制重要癌基因ki-Ras4B异戊二烯化的化合物.不幸的是,足以达到该终点的剂量迅速致死.
Doi:10.1021/jm020587N

专利信息

专利号:WO-2020248278-A1
优先权日:2019-06-14
标题:Method for continuous synthesis of substituted benzoic-acid organic substance
发明人：HONG HAO; ZHANG ENXUAN; LU JIANGPING; LIU ZHIQING; LI CHAO; TANG YANG
权利人:JINLIN ASYMCHEM LABORATORIES CO LTD
摘要:The present invention provides a method for the continuous synthesis of a substituted benzoic-acid organic substance. The continuous synthesis method comprises: in the presence of catalyst and organic solvent, the organic matter represented by formula (I) and oxygen are continuously inputted to a continuous reaction apparatus for continuous oxidation reaction to obtain a substituted benzoic-acid organic substance, which is discharged continuously, the substituted benzoic-acid organic substance having the structure represented by formula (II). Oxygen is a green reagent and is inexpensive and readily available; a large amount of wastewater, waste gas, and solid waste is not generated after the reaction, and the system is easy to handle. The use of a continuous reaction operation can reduce the risk of flash distillation and explosion of solvent due to a high concentration of oxygen in a batch reaction. Under the same oxidation conditions, the continuous preparation process can reduce the escape of oxygen, greatly increasing the oxygen utilization rate and also simplifying the operation, improving the safety of the reaction and the yield of the substituted benzoic-acid organic substance.

专利号:WO-2020248279-A1
优先权日:2019-06-14
标 题 :Continuous synthesis method for substituted benzoate organic matter
发明人：HONG HAO; LU JIANGPING; ZHANG ENXUAN; LIU ZHIQING; LI CHAO
权利人:JINLIN ASYMCHEM LABORATORIES CO LTD
摘要:The present invention provides a continuous synthesis method for a substituted benzoate organic matter. The continuous synthesis method comprises: in the presence of a catalyst and an organic solvent, continuously feeding an organic matter as represented by formula (I) and oxygen into a continuous reaction device for continuous oxidation reaction to obtain a substituted benzoate organic matter, and performing continuous discharge, wherein the substituted benzoate organic matter has a structure as represented by formula (II). Oxygen is a green reagent, and is cheap and easy to obtain; the present invention would not produce a large amount of waste gas, waste water, and waste residues after the completion of reaction, and the system is easy to handle. The use of continuous reaction operation can reduce the risk of solvent flash evaporation explosion due to high concentration oxygen in batch reactions. Under the same oxidation conditions, the use of a continuous preparation process can reduce the escape of oxygen, greatly increase the utilization of oxygen, simplify the operation, and improve the reaction safety and the yield of substituted benzoate organic matters.

专利号:BR-112016017679-B1
优先权日:2014-02-21
标题 :5-BENZYLISOQUINOLINE DERIVATIVE COMPOUNDS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES, PROCESS FOR THE SYNTHESIS OF SUCH COMPOUNDS AND PHARMACEUTICAL COMPOSITION CONTAINING THEM

专利号:CN-102372618-B
优先权日:2011-10-20
标题 :Practical Synthesis of 2-Halo-1-(4-Bromo-3-fluorophenyl)ethanone

专利号:CN-102372618-A
优先权日:2011-10-20
标题:Practical Synthesis of 2-Halo-1-(4-Bromo-3-fluorophenyl)ethanone

专利号:US-5334753-A
优先权日:1992-03-12
标题 :Processes for preparing ortho-substituted benzoic acids
发明人：BENNETAU BERNARD; CAIN PAUL A
权利人:RHONE POULENC AGRICULTURE
摘要:A novel process for the synthesis of ortho-substituted benzoic acid by lithiating an unprotected benzoic acid and a number of novel orth-substituted benzoic acids are described.