CAS: 1498-42-6; Dichloro(Ethoxy)Phosphane

上下游产品

ethanol Triethyl orthopropionate triethyl phosphite diethyl phosphorylchloriditephosphorous acid ethyl ester-bis-(4-nitro-phenyl ester) trityl-phosphonic acid ethyl ester chloride Cbz-Phe-Gly-OBn O.O.S-Triaethyl-dithiophosphat

📜三甲基乙氧基硅烷置于吡啶,三氯化磷体系中,用 二氯甲烷 用作溶剂,化学反应 27.0H,以85%的收率获得乙基二氯磷酸酯
参考文献:亚磷酸二氯,亚氯酸和亚磷酸三烷基酯的合成新方法
标题:亚磷酸二氯,亚氯酸和亚磷酸三烷基酯的合成新方法
摘要:使用相应的氯膦和烷氧基三甲基硅烷的 Hcl 催化反应,通过烷氧基和氯配体 (P Iii Cl/rosir' 3) 的相互交换,可以很容易地合成不同的三价有机磷酯,例如二氯亚磷酸酯,亚磷酸酯和混合亚磷酸三烷基酯. ;交换反应).还研究了分别与伯烷氧基三甲基硅烷和仲烷氧基三甲基硅烷以及烷氧基三甲基硅烷和硫代烷氧基三甲基硅烷的交换反应的化学选择性.还发现氯膦与仲胺的取代反应比与rosir' 3 的交换反应发生得更快.
Doi:10.1080/10426500902719222

专利信息

专利号:US-2004106815-A1
优先权日:2002-12-02
标题 :Selective synthesis of organophosphites

专利号:US-2012172336-A2
优先权日:2009-03-19
标 题:Fosfluconazole Derivatives, Synthesis, and Use in Long Acting Formulations
发明人：GONNISSEN YVES; VOORSPOELS JODY
权利人:GONNISSEN YVES; VOORSPOELS JODY; SEPS PHARMA N V
摘要:The invention relates to a compound of formula (1) and the salts, N-oxides, quaternary amines, and stereoisomers thereof, wherein R 1 to R 2 are as defined in the claims. The invention further relates to intermediates and methods for the preparation of the compounds of formula (I). The invention also relates to the compounds of formula (I) for use as a medicament, particularly for the prevention or treatment of fungal infections.

专利号:US-4537714-A
优先权日:1982-07-20
标 题 :Process for the preparation of lower alkyl esters of N-L-α-aspartyl-L-phenylalanine and of new intermediates for their preparation
发明人：MUELLER HANS-RUDOLF; BOLLINGER HEINRICH
权利人:EPROVA AG
摘要:The invention relates to a selective process for the preparation of N-L-α-aspartyl-L-phenylalanine-1-lower alkyl ester which comprises: n A. reacting an L-aspartic acid 4-arylmethyl ester with a n (i) 1,3-diketone; or n (ii) acylacetic ester; n in the presence of a base to form the salt of n (i') L-N-(1-alkyl-2-acyl-vinyl)-aspartic acid 4-arylmethyl ester; or n (ii') L-N-(1-alkyl-2-alkoxycarbonyl-vinyl)-aspartic acid 4-arylmethyl ester, n and then either: n (1) reacting salt (i') or (ii') with an organic or inorganic acid halide having the formula X-A, wherein X represents a halogen and A has the meaning indicated hereinafter, or with an acid anhydride to form ##STR1## wherein R represents an alkyl radical with 1 to 6 carbon atoms; n R' represents an alkyl or alkoxy radical with 1 to 6 carbon atoms; n Ar represents the phenyl, nitrophenyl, halogenphenyl or alkylphenyl radical; and n A represents an acyl with 2 to 12 carbon atoms, alkoxycarbonyl with 2 to 12 carbon atoms, or a phosphoric acid, phosphorous acid, sulfuric acid, sulfurous acid or sulfonic acid radical; n and reacting ester (I) with an L-phenylalanine lower alkyl ester; or n (2) reacting a salt of (i') or (ii') with a phosphorazo-L-phenyl lower alkyl ester; to form n (i') N-L-α-N'-(1-alkyl-2-acyl-vinyl)-aspartyl-L-phenylalanine-1-lower alkyl-4-arylmethyl ester; or n (ii') N-L-α-N'-(1-alkyl-2-alkoxycarbonyl)aspartyl-L-phenylalanine-1-lower alkyl-4-arylmethyl ester; n B. reacting (i') or (ii') with a strong acid to split off the respective N-(1-alkyl-2-acyl-vinyl) or N-(1-alkyl-2-alkoxycarbonyl-vinyl) protective group and produce: n (iii) N-L-α-aspartyl-L-phenylalanine-1-lower alkyl-4-(arylmethyl)ester; and n C. subjecting ester (iii) to catalytic hydrogenation to selectively split off the 4-(arylmethyl)-ester group and leave the N-L-α-aspartyl-L-phenylalanine-1-lower alkyl ester product. n Novel intermediates for the synthesis are also disclosed.

专利号:EP-1567468-B1
优先权日:2002-12-02
标题:A selective synthesis of organophosphites

专利号:RU-2164229-C2
优先权日:1994-10-19
标 题 :Antiviral substrate isoster esters of aspartate protease or their salts, method of their synthesis, pharmaceutical preparation and composition