CAS: 147065-05-2; 4-Chloro-D-Phenylalanine Hydrochloride

相似化合物

14091-08-8 14173-39-8 142994-19-2

2-Benzoylamino-3-(4-Chlorophenyl)Acrylic Acid置于盐酸,(+)-(S)-Cationic Rhodium Complex Of "Propharos",氢气体系中,用 甲醇 用作溶剂,25.0 °C,100.0 Kpa 条件下,反应 5.0H,反应生成4-氯-D-苯丙氨酸
参考文献:Unusual Amino Acids Iii. Asymmetric Synthesis Of 3-Arylalanines
标题:Unusual Amino Acids Iii. Asymmetric Synthesis Of 3-Arylalanines
摘要:21 (Z)-Alpha-N-Benzoylamino-Beta-Arylacrylic Acids And Their Esters Were Prepared By Known Procedures And Hydrogenated To The Corresponding Optically Active Alpha-Benzoyl-Beta-Arylalanine Derivatives With Optical Yields In The Range Of 82-95% Ee Using The Cationic Rhodium Complex Of ''Propraphos'' As The Chiral Catalyst No Electronical Influences Of The Substituents At The Aryl Moiety On The Enantioselectivity Were Observed But A Sterical One,Proved By X-Ray Crystallographic Analysis And Computer-Aided Modellings. Deacylation Of The Hydrogenated Spezies Produced The Hydrochlorides Of The 3-Arylalanines Attended By A Partial Racemisation In This Case The Hydrogenation Of Urethane Type Protected Dehydroaminoacid Derivatives Seems To Be The Alternative.
Doi:10.1016/s0957-4166(00)86017-6