Alkaline Earth Salt Of/the/ Methylsulfuric Acid 反应生成1,3-二溴-5-氟苯 参考文献:Cannoni De Degiorgi; Zappi,Anales Des La Asociacion Quimica Argentina,1940,Vol. 28,P. 72,80 标题:Cannoni De Degiorgi; Zappi,Anales Des La Asociacion Quimica Argentina,1940,Vol. 28,P. 72,80
专利信息
专利号:US-7615300-B2 优先权日:2005-08-30 标 题 :Development of novel proton-conductive polymers for proton exchange membrane fuel cell (PEMFC) technology 发明人:BAE CHULSUNG 权利人:REGENTS UNIVERSITY AND COMMUNI 摘要:New thermally and chemically stable sulfonic acid-containing polymers are synthesized via post-sulfonation of aromatic polymers. These new polymers provide unique benefits to proton exchange membrane fuel cell technology (“PEMFCâ€?). As a sulfonic acid moiety can be easily installed into an aromatic ring via electrophilic sulfonation, even in the presence of an electron-withdrawing substituent such as —F, rigid polymers consisting of aromatic rings at either the side chain or main chain can be prepared with a wide range of substituents and flexibility in properties. Novel synthetic procedures are provided for synthesis of the polymers.
专利号:US-7754188-B2 优先权日:2003-06-30 标 题:Radiolabeled cannabinoid-1 receptor modulators 发明人:BURNS H DONALD; CHEN ALEX M; GIBSON RAYMOND E; GOULET MARK T; HAGMANN WILLIAM K; HAMILL TERENCE G; JEWELL JAMES P; LIN LINUS S; LIU PING; PERESYPKIN ANDREY V 权利人:MERCK SHARP & DOHME 摘要:The present invention relates to particular radiolabeled Cannabinoid-1 (CB1) receptor modulators, and methods of using these modulators for labeling and diagnostic imaging of Cannabinoid-1 receptors in mammals, particularly humans. In addition, intermediates useful for the synthesis of the radiolabeled Cannabinoid-1 receptor modulators are also disclosed, as well as the processes for synthesizing the radiolabeled Cannabinoid-1 receptor modulators. Still further, formulations of the radiolabeled Cannabinoid-1 receptor compounds are described.
专利号:US-12227528-B2 优先权日:2017-11-09 标 题:Glucose-sensitive albumin-binding derivatives 发明人:KRUSE THOMAS; KOFOD-HANSEN MIKAEL; MUENZEL MARTIN WERNER BORCHSENIUS; THOEGERSEN HENNING; SAUERBERG PER; EWALD JAKOB; BEHRENS CARSTEN; HOEG-JENSEN THOMAS; BALSANEK VOJTECH; DROBNAKOVA ZUZANA; DROZ LADISLAV; HAVRANEK MIROSLAV; KOTEK VLADISLAV; STENGL MILAN; SNAJDR IVAN; DRUSANOVA HANA 权利人:NOVO NORDISK AS 摘要:This invention relates to glucose-sensitive albumin-binding diboron conjugates. More particularly the invention provides novel diboron compounds, and in particular diboronate or diboroxole compounds, useful as intermediate compounds for the synthesis of diboron conjugates.
专利号:WO-2009054923-A2 优先权日:2007-10-24 标 题 :Synthesis and crystalline forms of cb-1 antagonist/inverse agonist
专利号:US-2010292282-A1 优先权日:2007-10-24 标题:Synthesis and crystalline forms of cb-1 antagonist/inverse agonist 发明人:CAMPOS KEVIN R; CHEN CHENG-YI; FOLEY JENNIFER R; HILLIER MICHAEL; JEN WENDY S; KASSIM AMUDE M; KLAPARS ARTIS; PERESYPKIN ANDREY V; ROSNER THORSTEN; SAVARIN CECILE G; TUDGE MATTHEW; VARIANKAVAL NARAYAN; VYDRA VICKY; ZHAO DALIAN 权利人:CAMPOS KEVIN R; CHEN CHENG-YI; FOLEY JENNIFER R; HILLIER MICHAEL; JEN WENDY S; KASSIM AMUDE M; KLAPARS ARTIS; PERESYPKIN ANDREY V; ROSNER THORSTEN; SAVARIN CECILE G; TUDGE MATTHEW; VARIANKAVAL NARAYAN; VYDRA VICKY; ZHAO DALIAN 摘要:The present invention relates to a process for producing crystalline 3-[(1S)-1-(1-{(S)-(4-chlorophenyl)[3-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)phenyl]methyl}azetidin-3-yl)-2-fluoro-2-methyl-propyl]-5-fluorobenzonitrile, and novel salts, solvates, hydrates and polymorphs thereof.